Rosemary Blake
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View article: Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screen
Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screen Open
Influenza A virus (IAV) causes major economic losses to the poultry industry and poses a zoonotic threat to human health. Potential pandemic outbreaks are underpinned by the ability of the virus to jump from one species to another. Host-vi…
View article: Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease
Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease Open
Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human disease due to …
View article: Differential role of M cells in enteroid infection by Mycobacterium avium subsp. paratuberculosis and Salmonella enterica serovar Typhimurium
Differential role of M cells in enteroid infection by Mycobacterium avium subsp. paratuberculosis and Salmonella enterica serovar Typhimurium Open
Infection of ruminants such as cattle with Mycobacterium avium subsp . paratuberculosis (MAP) causes Johne’s disease, a disease characterized by chronic inflammation of the small intestine and diarrhoea. Infection with MAP is acquired via …
View article: The role of Mce proteins in Mycobacterium avium paratuberculosis infection
The role of Mce proteins in Mycobacterium avium paratuberculosis infection Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s Disease, a chronic granulomatous enteritis of ruminants. MAP establishes an infection in the host via the small intestine. This requires the bacterium …
View article: Role of Mce proteins in<i>Mycobacterium avium paratuberculosis</i>infection
Role of Mce proteins in<i>Mycobacterium avium paratuberculosis</i>infection Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s Disease, a chronic granulomatous enteritis of ruminants. MAP establishes an infection in the host via the small intestine. This requires the bacteria t…
View article: The Development of 3D Bovine Intestinal Organoid Derived Models to Investigate Mycobacterium Avium ssp Paratuberculosis Pathogenesis
The Development of 3D Bovine Intestinal Organoid Derived Models to Investigate Mycobacterium Avium ssp Paratuberculosis Pathogenesis Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the etiological agent of Johne's Disease, a chronic enteritis of ruminants prevalent across the world. It is estimated that approximately 50% of UK dairy herds are infected with MAP,…
View article: Using Species a Rotavirus Reverse Genetics to Engineer Chimeric Viruses Expressing SARS-CoV-2 Spike Epitopes
Using Species a Rotavirus Reverse Genetics to Engineer Chimeric Viruses Expressing SARS-CoV-2 Spike Epitopes Open
We explored the use of rotaviruses (RVs) to express heterologous peptides, using SARS-CoV-2 as an example. Small SARS-CoV-2 peptide insertions (<34 amino acids) into the hypervariable region of the viral protein 4 (VP4) of RV SA11 strain r…
View article: The development of 3D bovine intestinal organoid derived models to investigate <i>Mycobacterium avium</i> ssp <i>paratuberculosis</i> pathogenesis
The development of 3D bovine intestinal organoid derived models to investigate <i>Mycobacterium avium</i> ssp <i>paratuberculosis</i> pathogenesis Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the etiologic agent of Johne’s Disease, a chronic enteritis of ruminants prevalent across the world. It is estimated that approximately 50% of UK dairy herds are infected with MAP, b…
View article: Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes
Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes Open
Human rotavirus (RV) vaccines used worldwide have been developed using live attenuated platforms. The recent development of a reverse genetics system for RVs has delivered the possibility of engineering chimeric viruses expressing heterolo…