Explanipedia

Fertility and pregnancy in adrenal insufficiency Open

Deirdre Green, Rosemary Dineen, Michael O’Reilly, Mark Sherlock · 2023

Despite the availability of adrenal hormone replacement therapy, patients with adrenal insufficiency can be affected by reduced fertility and parity. Patients with well-managed adrenal insufficiency are expected to have uneventful pregnanc…

Distinct inflammatory signatures of upper and lower body adipose tissue and adipocytes in women with normal weight or obesity Open

Ioannis Lempesis, Nicole Hoebers, Yvonne Essers, Johan W. E. Jocken, Rosemary Dineen , et al. · 2023

Introduction Upper and lower body fat accumulation poses an opposing obesity-related cardiometabolic disease risk. Depot-differences in subcutaneous adipose tissue (SAT) function may underlie these associations. We aimed to investigate the…

Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy Open

Rosemary Dineen, Julie Martin‐Grace, Khalid Mohamed Ahmed, Angela E. Taylor, Fozia Shaheen , et al. · 2023

Background Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). We…

Response to the letter of Patra and colleagues Open

Rosemary Dineen, Mark Sherlock · 2021

A Prospective Cross-Over Study of Tissue Glucocorticoid Metabolism in Patients With Adrenal Insufficiency: The Effects of Dual-Release Hydrocortisone Therapy Open

Rosemary Dineen, Julie Martin‐Grace, Khalid Mohamed Ahmed, Angela E. Taylor, Fozia Shaheen , et al. · 2021

Background: Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). W…

The contribution of serum cortisone and glucocorticoid metabolites to detrimental bone health in patients receiving hydrocortisone therapy Open

Rosemary Dineen, Lucy‐Ann Behan, Grainne Kelleher, Mark J. Hannon, Jennifer J. Brady , et al. · 2020

Background Glucocorticoid therapy is the most common cause of iatrogenic osteoporosis. Less is known regarding the effect of glucocorticoids when used as replacement therapy on bone remodelling in patients with adrenal insufficiency. Enhan…

Fluid Restriction Therapy for Chronic SIAD; Results of a Prospective Randomized Controlled Trial Open

Aoife Garrahy, Iona Galloway, Anne Marie Hannon, Rosemary Dineen, Patrick O’Kelly , et al. · 2020

Context Fluid restriction (FR) is the recommended first-line treatment for syndrome of inappropriate antidiuresis (SIAD), despite the lack of prospective data to support its efficacy. Design A prospective nonblinded randomized controlled t…

Issue Information Open

Tamara Feygin, Nahla Khalek, Julie S. Moldenhauer, Lisa M. Pastore, L.J. Rubin , et al. · 2020

Adrenal Incidentaloma Open

Mark Sherlock, Andrew Scarsbrook, Afroze Abbas, Sheila Fraser, Padiporn Limumpornpetch , et al. · 2020

An adrenal incidentaloma is now established as a common endocrine diagnosis that requires a multidisciplinary approach for effective management. The majority of patients can be reassured and discharged, but a personalized approach based up…

The contribution of serum cortisone and glucocorticoid metabolites to detrimental bone health in patients receiving hydrocortisone therapy Open

Rosemary Dineen, Lucy‐Ann Behan, Grainne Kelleher, Mark J. Hannon, Jennifer J. Brady , et al. · 2020

Background: Glucocorticoid therapy is the most common cause of iatrogenic osteoporosis. Less is known regarding the effect of glucocorticoids when used as replacement therapy on bone remodelling in patients with adrenal insufficiency. Enha…

MON-447 Impact Of Cortisone And Glucocorticoid Metabolites On Bone Turnover Markers in Male Patients With Hypopituitarism Open

Rosemary Dineen, Lucy‐Ann Behan, Grainne Kelleher, Mark J. Hannon, Jennifer J. Brady , et al. · 2019

Background: Glucocorticoid therapy is the most common cause of iatrogenic osteoporosis. Less is known on the effect of glucocorticoids on bone remodeling when used as replacement therapy in patients with adrenal insufficiency. Enhanced int…

Continuous Versus Bolus Infusion of Hypertonic Saline in the Treatment of Symptomatic Hyponatremia Caused by SIAD Open

Aoife Garrahy, Rosemary Dineen, Anne Marie Hannon, Martín Cuesta, William Tormey , et al. · 2019

Background Acute hyponatremia is a medical emergency that confers high mortality, attributed primarily to cerebral edema. Expert guidelines advocate the use of intravenous boluses of hypertonic saline rather than traditional continuous inf…

Adrenal crisis: prevention and management in adult patients Open

Rosemary Dineen, Christopher J. Thompson, Mark Sherlock · 2019

Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. The incidence of adrenal crisis is estimated to be 8 per 100 patient years in patients with…

Factors impacting on the action of glucocorticoids in patients receiving glucocorticoid therapy Open

Rosemary Dineen, Paul M. Stewart, Mark Sherlock · 2018

Summary Glucocorticoids ( GC s) are steroid hormones, which are essential for life. They are secreted by the adrenal cortex under the control of the hypothalamic‐pituitary‐adrenal ( HPA ) axis. Glucocorticoids are essential for the normal …

Ripping at the Seams: Stories of a Too-Fat, Fractured, Feminist Killjoy Open

Rosemary Dineen · 2018

Endocrinopathies and renal outcomes in lithium therapy: impact of lithium toxicity Open

Rosemary Dineen, Delia Bogdanet, Dan Thompson, Chris Thompson, LA Behan , et al. · 2017

Stage 3 CKD is common in patients receiving lithium therapy. Lithium toxicity is associated with CKD and hypernatraemia. Thyroid dysfunction and hypercalcaemia are common in patients receiving lithium therapy. Patients receiving lithium th…

Hyponatraemia – presentations and management Open

Rosemary Dineen, Christopher J. Thompson, Mark Sherlock · 2017

ACTH and gonadotropin deficiencies predict mortality in patients treated for nonfunctioning pituitary adenoma: long‐term follow‐up of 519 patients in two large European centres Open

Michael O’Reilly, Raoul C. Reulen, Saket Gupta, Claire A. Thompson, Rosemary Dineen , et al. · 2016

Summary Context and Objective Nonfunctioning pituitary adenomas ( NFPA s) are the most common subtype of pituitary tumour. Hypopituitarism is observed in NFPA s due to tumour‐ or treatment‐related factors and may increase mortality risk. H…

Heterogenous patterns of recovery of thirst in adult patients with adipsic diabetes insipidus Open

Martín Cuesta, Saket Gupta, Ridhwaan Salehmohamed, Rosemary Dineen, Mark J. Hannon , et al. · 2015

We report that 3/12 patients with ADI recovered thirst after longstanding adipsia with heterogenous pattern of recovery. Both the mortality of 25% and the recovery rate of 25% should be considered when planning long-term surveillance.

Endocrinopathies associated with lithium therapy in an Irish tertiary referral centre Open

Rosemary Dineen, Delia Bogdanet, C J Thompson, David R. Thompson, Gerard Boran , et al. · 2015

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Cushing's disease in a 7-year-boy due to corticotroph cell hyperplasia Open

Rosemary Dineen, Karen McGurren, Mohsen Javadpour, Colm Costigan, Amar Agha · 2015

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Recurrent severe symptomatic hyponatraemia induced by low-dose oral cyclophosphamide in a patient with ANA-related vasculitis Open

Rosemary Dineen, Agnieszka Pazderska, Ronan Mullan, James Gibney, Mark Sherlock · 2015

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

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