Roshan Karunamuni
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View article: RADT-66. REDEFINING BRAIN RADIOSURGERY: A CONNECTOME-BASED PARADIGM FOR COGNITIVE PRESERVATION ON THE COG-SRS TRIAL
RADT-66. REDEFINING BRAIN RADIOSURGERY: A CONNECTOME-BASED PARADIGM FOR COGNITIVE PRESERVATION ON THE COG-SRS TRIAL Open
Stereotactic radiosurgery (SRS) is standard treatment for a range of intracranial tumors. However, with conventional SRS plans, injury to white matter tracts (WMT) and hippocampi (HC) can occur, impairing cognition in a majority of patient…
View article: CTLT-05 PRESERVING COGNITIVE FUNCTION DURING RADIOSURGERY FOR METASTATIC BRAIN DISEASE: RESULTS FROM THE COG-SRS TRIAL
CTLT-05 PRESERVING COGNITIVE FUNCTION DURING RADIOSURGERY FOR METASTATIC BRAIN DISEASE: RESULTS FROM THE COG-SRS TRIAL Open
Stereotactic radiosurgery (SRS) is often the treatment of choice for limited metastatic brain disease. However, SRS with standard treatment planning results in cognitive decline in the majority of patients. Herein, we report cognitive outc…
View article: Beyond the hippocampus: Limbic white matter injury implicated in post-radiation memory performance in primary brain tumor patients
Beyond the hippocampus: Limbic white matter injury implicated in post-radiation memory performance in primary brain tumor patients Open
Background Limbic white matter (WM) of the Papez circuit, including the fornix, dorsal cingulum, and parahippocampal cingulum (PHC), interplay with the hippocampus as key components of the memory network. We analyzed biomarkers of injury t…
View article: Specificity of a polygenic score for aggressive prostate cancer
Specificity of a polygenic score for aggressive prostate cancer Open
To address the concern that polygenic hazard scores for prostate cancer (PCa) might not distinguish between indolent and aggressive disease, we performed case-only analyses using a 601-variant polygenic score (PHS601). We hypothesized that…
View article: From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study
From a genomic risk model to clinical trial implementation in a learning health system: the ProGRESS Study Open
Background As healthcare moves from a one-size-fits-all approach towards precision care, individual risk prediction is an important step in disease prevention and early detection. Biobank-linked healthcare systems can generate knowledge ab…
View article: OCTS-09 THE PROSPECTIVE PHASE II COG-SRS TRIAL: AN UPDATE ON COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES
OCTS-09 THE PROSPECTIVE PHASE II COG-SRS TRIAL: AN UPDATE ON COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES Open
Stereotactic radiosurgery (SRS) plans that respect the neural correlates of cognition should result in better post-treatment cognitive outcomes compared to standard plans. The prospective phase II COG-SRS Trial is designed to test this hyp…
View article: Agent orange exposure and prostate cancer risk in the million veteran program
Agent orange exposure and prostate cancer risk in the million veteran program Open
Background: The US government considers veterans to have been exposed to Agent Orange if they served in Vietnam while the carcinogen was in use, and these veterans are often deemed at high risk of prostate cancer (PCa). Here, we assess whe…
View article: Utility of quantitative measurement of<i>T<sub>2</sub></i>using Restriction Spectrum Imaging for detection of clinically significant prostate cancer
Utility of quantitative measurement of<i>T<sub>2</sub></i>using Restriction Spectrum Imaging for detection of clinically significant prostate cancer Open
Background The Restriction Spectrum Imaging restriction score (RSIrs) has demonstrated higher diagnostic accuracy for clinically significant prostate cancer (csPCa) than conventional DWI. Both diffusion and T 2 properties of prostate tissu…
View article: An accessible deep learning tool for voxel-wise classification of brain malignancies from perfusion MRI
An accessible deep learning tool for voxel-wise classification of brain malignancies from perfusion MRI Open
View article: Clinical Impact of Contouring Variability for Prostate Cancer Tumor Boost
Clinical Impact of Contouring Variability for Prostate Cancer Tumor Boost Open
Purpose The focal radiotherapy (RT) boost technique was shown in the FLAME trial to improve prostate cancer outcomes without increasing toxicity. This technique relies on the accurate delineation of prostate tumors on MRI. The ReIGNITE RT …
View article: RADT-50. EVIDENCE-BASED MULTIVARIATE NORMAL TISSUE COMPLICATION PROBABILITY (NTCP) STUDY OF DOMAIN-SPECIFIC COGNITIVE DECLINE AFTER PARTIAL BRAIN RADIATION (RT)
RADT-50. EVIDENCE-BASED MULTIVARIATE NORMAL TISSUE COMPLICATION PROBABILITY (NTCP) STUDY OF DOMAIN-SPECIFIC COGNITIVE DECLINE AFTER PARTIAL BRAIN RADIATION (RT) Open
Beyond the hippocampus, there are no evidence-based dose constraints for eloquent brain structures which subserve cognitive domains. We performed a multivariate NTCP analysis of post-RT neurocognitive decline, examining dosimetric predicto…
View article: LMAP-17 FEASIBILITY OF COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES: INITIAL REPORT OF PHASE II COG-SRS TRIAL
LMAP-17 FEASIBILITY OF COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES: INITIAL REPORT OF PHASE II COG-SRS TRIAL Open
Radiotherapy at high doses leads to white matter (WM) and hippocampal injury which can cause cognitive decline. We designed the first, to our knowledge, evidence-based cognitive-sparing brain SRS trial for patients with limited brain metas…
View article: ReIGNITE Radiation Therapy Boost: A Prospective, International Study of Radiation Oncologists’ Accuracy in Contouring Prostate Tumors for Focal Radiation Therapy Boost on Conventional Magnetic Resonance Imaging Alone or With Assistance of Restriction Spectrum Imaging
ReIGNITE Radiation Therapy Boost: A Prospective, International Study of Radiation Oncologists’ Accuracy in Contouring Prostate Tumors for Focal Radiation Therapy Boost on Conventional Magnetic Resonance Imaging Alone or With Assistance of Restriction Spectrum Imaging Open
View article: Agent Orange exposure and prostate cancer risk in the Million Veteran Program
Agent Orange exposure and prostate cancer risk in the Million Veteran Program Open
Purpose Exposure to Agent Orange, a known carcinogen, might increase risk of prostate cancer (PCa). We sought to investigate the association of Agent Orange exposure and PCa risk when accounting for race/ethnicity, family history, and gene…
View article: Fine Motor Skill Decline After Brain Radiation Therapy—A Multivariate Normal Tissue Complication Probability Study of a Prospective Trial
Fine Motor Skill Decline After Brain Radiation Therapy—A Multivariate Normal Tissue Complication Probability Study of a Prospective Trial Open
View article: The relationship between radiation dose and bevacizumab-related imaging abnormality in patients with brain tumors: A voxel-wise normal tissue complication probability (NTCP) analysis
The relationship between radiation dose and bevacizumab-related imaging abnormality in patients with brain tumors: A voxel-wise normal tissue complication probability (NTCP) analysis Open
Purpose Bevacizumab-related imaging abnormality (BRIA), appearing as areas of restricted diffusion on magnetic resonance imaging (MRI) and representing atypical coagulative necrosis pathologically, has been observed in patients with brain …
View article: Response to Haiman, Kote-Jarai, Darst et al.
Response to Haiman, Kote-Jarai, Darst et al. Open
View article: An Accessible Deep Learning Tool for Voxel-Wise Classification of Brain Malignancies from Perfusion MRI
An Accessible Deep Learning Tool for Voxel-Wise Classification of Brain Malignancies from Perfusion MRI Open
View article: Automated Patient-level Prostate Cancer Detection with Quantitative Diffusion Magnetic Resonance Imaging
Automated Patient-level Prostate Cancer Detection with Quantitative Diffusion Magnetic Resonance Imaging Open
We evaluated a rapid, advanced prostate magnetic resonance imaging technique called restriction spectrum imaging to see whether it could give an automated score that predicted the presence of clinically significant prostate cancer. The aut…
View article: ReIGNITE RT Boost: An international study testing the accuracy and feasibility of using restriction spectrum imaging (RSI) MRI to guide intraprostatic tumor target volume for radiotherapy boost
ReIGNITE RT Boost: An international study testing the accuracy and feasibility of using restriction spectrum imaging (RSI) MRI to guide intraprostatic tumor target volume for radiotherapy boost Open
In a phase III randomized trial, adding a radiation boost to visible tumor(s) on MRI improved prostate cancer disease-free and metastasis-free survival without additional toxicity. However, radiation oncologists’ ability to identify prosta…
View article: An accessible deep learning tool for voxel-wise classification of brain malignancies from perfusion MRI
An accessible deep learning tool for voxel-wise classification of brain malignancies from perfusion MRI Open
Non-invasive differential diagnosis of brain tumours is currently based on the assessment of tumour vascularity through magnetic resonance imaging (MRI) coupled with dynamic susceptibility contrast (DSC). However, given its limited accurac…
View article: NCOG-37. MICROSTRUCTURAL CEREBELLAR INJURY IS ASSOCIATED WITH PROCESSING SPEED DECLINE IN ADULTS WITH PRIMARY BRAIN TUMORS: IMPLICATIONS FOR COGNITIVE PRESERVATION
NCOG-37. MICROSTRUCTURAL CEREBELLAR INJURY IS ASSOCIATED WITH PROCESSING SPEED DECLINE IN ADULTS WITH PRIMARY BRAIN TUMORS: IMPLICATIONS FOR COGNITIVE PRESERVATION Open
PURPOSE We investigated associations between imaging biomarkers of cerebellar injury and neurocognitive function among primary brain tumor patients receiving partial brain radiotherapy (RT). METHODS On a prospective trial, 65 patients unde…
View article: Background prostate tissue is quantitatively abnormal on MRI in patients with clinically significant prostate cancer
Background prostate tissue is quantitatively abnormal on MRI in patients with clinically significant prostate cancer Open
Background T 2 -weighted MRI is standard for detecting clinically significant prostate cancer (csPCa) by identifying visible lesions that stand out from the background prostate. Purpose To determine whether patients with csPCa have abnorma…
View article: Fine Motor Skill Decline after Brain RT – A Multivariate Normal Tissue Complication Probability Study of a Prospective Trial
Fine Motor Skill Decline after Brain RT – A Multivariate Normal Tissue Complication Probability Study of a Prospective Trial Open
Purpose Brain radiotherapy can impair fine motor skills (FMS). FMS are essential for activities of daily living, enabling hand-eye coordination for manipulative movements. We developed normal tissue complication probability (NTCP) models f…
View article: Automated segmentation of multiparametric magnetic resonance images for cerebral AVM radiosurgery planning: a deep learning approach
Automated segmentation of multiparametric magnetic resonance images for cerebral AVM radiosurgery planning: a deep learning approach Open
Stereotactic radiosurgery planning for cerebral arteriovenous malformations (AVM) is complicated by the variability in appearance of an AVM nidus across different imaging modalities. We developed a deep learning approach to automatically s…
View article: Correcting B0 inhomogeneity-induced distortions in whole-body diffusion MRI of bone
Correcting B0 inhomogeneity-induced distortions in whole-body diffusion MRI of bone Open
Diffusion-weighted magnetic resonance imaging (DWI) of the musculoskeletal system has various applications, including visualization of bone tumors. However, DWI acquired with echo-planar imaging is susceptible to distortions due to static …
View article: Low Dose to White Matter Predicts Attention and Processing Speed Decline After Fractionated Brain RT
Low Dose to White Matter Predicts Attention and Processing Speed Decline After Fractionated Brain RT Open
View article: Quality of Life Is Independently Associated With Neurocognitive Function in Patients With Brain Tumors: Analysis of a Prospective Clinical Trial
Quality of Life Is Independently Associated With Neurocognitive Function in Patients With Brain Tumors: Analysis of a Prospective Clinical Trial Open
View article: Patient-level detection of grade group ≥2 prostate cancer using quantitative diffusion MRI
Patient-level detection of grade group ≥2 prostate cancer using quantitative diffusion MRI Open
Purpose Multiparametric MRI (mpMRI) improves detection of clinically significant prostate cancer (csPCa), but the qualitative PI-RADS system and quantitative apparent diffusion coefficient (ADC) yield inconsistent results. An advanced Rest…
View article: Voxel‐level Classification of Prostate Cancer on Magnetic Resonance Imaging: Improving Accuracy Using <scp>Four‐Compartment</scp> Restriction Spectrum Imaging
Voxel‐level Classification of Prostate Cancer on Magnetic Resonance Imaging: Improving Accuracy Using <span>Four‐Compartment</span> Restriction Spectrum Imaging Open
Background Diffusion magnetic resonance imaging (MRI) is integral to detection of prostate cancer (PCa), but conventional apparent diffusion coefficient (ADC) cannot capture the complexity of prostate tissues and tends to yield noisy image…