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View article: Afucosylated IgG Targets FcγRIV for Enhanced Tumor Therapy in Mice
Afucosylated IgG Targets FcγRIV for Enhanced Tumor Therapy in Mice Open
Promising strategies for maximizing IgG effector functions rely on the introduction of natural and non-immunogenic modifications. The Fc domain of IgG antibodies contains an N-linked oligosaccharide at position 297. Human IgG antibodies la…
View article: The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access
The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access Open
Summary HLA class I (HLA-I) drives immune responses by presenting antigen-derived peptides to cognate CD8 + T cells. This process is often hijacked by tumors and pathogens for immune evasion. Since therapeutic options for restoring HLA-I a…
View article: Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Open
Variation in key transcription factors and glycogenes modifies IgG glycosylation and has an influence on inflammatory diseases.
View article: Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Open
Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood abou…
View article: Comparative Glycomics of Immunoglobulin A and G From Saliva and Plasma Reveals Biomarker Potential
Comparative Glycomics of Immunoglobulin A and G From Saliva and Plasma Reveals Biomarker Potential Open
The N-glycosylation of immunoglobulin (Ig) G, the major antibody in the circulation of human adults, is well known for its influence on antibody effector functions and its alterations with various diseases. In contrast, knowledge on the ro…
View article: Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns
Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns Open
Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for t…
View article: Adaptive antibody diversification through <i>N</i> -linked glycosylation of the immunoglobulin variable region
Adaptive antibody diversification through <i>N</i> -linked glycosylation of the immunoglobulin variable region Open
Significance Structural variation of antibodies is generally defined in terms of amino acid composition, neglecting posttranslational modifications such as N -linked glycosylation. Little is known about the role of the glycans that are pre…
View article: Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities
Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities Open
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera. Several groups have found global or antigen-spe…
View article: Antigen specificity determines anti‐red blood cell IgG‐Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn
Antigen specificity determines anti‐red blood cell IgG‐Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn Open
Summary Haemolytic disease of the fetus and newborn (HDFN) is a severe disease in which fetal red blood cells (RBC) are destroyed by maternal anti‐RBC IgG alloantibodies. HDFN is most often caused by anti‐D but may also occur due to anti‐K…
View article: Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans
Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans Open
Immunoglobulin G (IgG) mediates its immune functions through complement and cellular IgG-Fc receptors (FcγR). IgG contains an evolutionary conserved N -linked glycan at position Asn297 in the Fc-domain. This glycan consists of variable lev…