Ross A. Jones
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View article: Threshold-Anchored Mechanomyography Metrics for Patient Stratification in Spinal Decompression: Associations with Early Pain Outcomes
Threshold-Anchored Mechanomyography Metrics for Patient Stratification in Spinal Decompression: Associations with Early Pain Outcomes Open
Background/Objectives: Spinal decompression surgery shows variable outcomes, with reoperation rates up to 37.5%. Surgeons lack objective intraoperative tools to assess decompression adequacy. Mechanomyography (MMG) measures nerve excitabil…
View article: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction
Expansion microscopy reveals nano-scale insights into the human neuromuscular junction Open
The neuromuscular junction (NMJ) is a specialized synapse that relays signals from the lower motor neuron to the skeletal muscle. Here, we detail the development and application of expansion microscopy (ExM) as a highly accessible, relativ…
View article: The Wade Programme in surgical anatomy: educational approach and 10-year review
The Wade Programme in surgical anatomy: educational approach and 10-year review Open
The Wade Programme was established to support the study of surgical anatomy throughout training, from undergraduate study to consultant practice. The Wade Approach should also be of help to all who are engaged in anatomy education and the …
View article: Cover Image, Volume 49, Issue 4
Cover Image, Volume 49, Issue 4 Open
The cover image is based on the Original Article Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis by Abrar Alhindi et al., https://doi.org/10.1111/…
View article: Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP‐43 overexpression mouse model of amyotrophic lateral sclerosis
Neuromuscular junction denervation and terminal Schwann cell loss in the hTDP‐43 overexpression mouse model of amyotrophic lateral sclerosis Open
Aims Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with complex aetiology. Despite evidence of neuromuscular junction (NMJ) denervation and ‘dying‐back’ pathology in models of SOD1‐dependent ALS, evidence in othe…
View article: Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor Open
Vascular calcification is associated with aging, type 2 diabetes, and atherosclerosis, and increases the risk of cardiovascular morbidity and mortality. It is an active, highly regulated process that resembles physiological bone formation.…
View article: A method to identify, dissect and stain equine neuromuscular junctions for morphological analysis
A method to identify, dissect and stain equine neuromuscular junctions for morphological analysis Open
Morphological study of the neuromuscular junction (NMJ), a specialised peripheral synapse formed between a lower motor neuron and skeletal muscle fibre, has significantly contributed to the understanding of synaptic biology and neuromuscul…
View article: Recognising the potential of large animals for modelling neuromuscular junction physiology and disease
Recognising the potential of large animals for modelling neuromuscular junction physiology and disease Open
The aetiology and pathophysiology of many diseases of the motor unit remain poorly understood and the role of the neuromuscular junction (NMJ) in this group of disorders is particularly overlooked, especially in humans, when these diseases…
View article: Improving surgical training: Establishing a surgical anatomy programme in Scotland
Improving surgical training: Establishing a surgical anatomy programme in Scotland Open
Background It is well recognized that a sound foundation in surgical anatomy is a cornerstone of safe surgical practice, yet many trainees struggle with the upskilling in anatomy that is required to support their day-to-day practice. In th…
View article: Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin
Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin Open
Live imaging of neuromuscular junctions (NMJs) in situ has been constrained by the suitability of ligands for inert vital staining of motor nerve terminals. Here, we constructed several truncated derivatives of the tetanus toxin C-fragment…
View article: Terminal Schwann cells at the human neuromuscular junction
Terminal Schwann cells at the human neuromuscular junction Open
Terminal Schwann cells are non-myelinating glial cells localized to the neuromuscular junction. They play an important role in regulating many aspects of neuromuscular junction form and function, in health and during disease. However, almo…
View article: Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models Open
Amyotrophic lateral sclerosis (ALS) is an incurable neurological disease with progressive loss of motor neuron (MN) function in the brain and spinal cord. Mutations in TARDBP, encoding the RNA-binding protein TDP-43, are one cause of ALS, …
View article: Confocal micrographs and complete dataset of neuromuscular junction morphology of pelvic limb muscles of the pig (Sus scrofa)
Confocal micrographs and complete dataset of neuromuscular junction morphology of pelvic limb muscles of the pig (Sus scrofa) Open
This dataset entails the complete NMJ dataset for three pigs and the three muscles analysed for the publication "Comparative anatomy of the mammalian neuromuscular junction" (https://doi.org/10.1111/joa.13260). This includes spreadsheets (…
View article: Comparative anatomy of the mammalian neuromuscular junction
Comparative anatomy of the mammalian neuromuscular junction Open
The neuromuscular junction (NMJ)—a synapse formed between lower motor neuron and skeletal muscle fibre—represents a major focus of both basic neuroscience research and clinical neuroscience research. Although the NMJ is known to play an im…
View article: Confocal micrographs and complete dataset of neuromuscular junction morphology of pelvic limb muscles of the pig (Sus scrofa)
Confocal micrographs and complete dataset of neuromuscular junction morphology of pelvic limb muscles of the pig (Sus scrofa) Open
This dataset entails the complete NMJ dataset for three pigs and the three muscles analysed for the publication "Comparative anatomy of the mammalian neuromuscular junction" (https://doi.org/10.1111/joa.13260). This includes spreadsheets (…
View article: aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology
aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology Open
Large-scale data analysis of synaptic morphology is becoming increasingly important to the field of neurobiological research (e.g. ‘connectomics’). In particular, a detailed knowledge of neuromuscular junction (NMJ) morphology has proven t…
View article: Supplementary material from "aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology"
Supplementary material from "aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology" Open
Large-scale data analysis of synaptic morphology is becoming increasingly important to the field of neurobiological research (e.g. ‘connectomics’). In particular, a detailed knowledge of neuromuscular junction (NMJ) morphology has proven t…
View article: Supplementary File 1 – aNMJ-morph macro text (Minty et al, 2020, RSOS) from aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology
Supplementary File 1 – aNMJ-morph macro text (Minty et al, 2020, RSOS) from aNMJ-morph: a simple macro for rapid analysis of neuromuscular junction morphology Open
Full IJM-text (ImageJ Macro Language) transcription (Minty et al, 2020, RSOS)
View article: Neuromuscular junctions are stable in patients with cancer cachexia
Neuromuscular junctions are stable in patients with cancer cachexia Open
Cancer cachexia is a major cause of patient morbidity and mortality, with no efficacious treatment or management strategy. Despite cachexia sharing pathophysiological features with a number of neuromuscular wasting conditions, including ag…
View article: BS13 Role for microRNA-26B in vessel calcification
BS13 Role for microRNA-26B in vessel calcification Open
Introduction MicroRNAs (miRNAs) are small non-coding RNAs that orchestrate genetic networks by modulating simultaneous gene expression and regulates vascular function. Despite recent accumulation of experimental data and the emergence of f…
View article: aNMJ-morph macro
aNMJ-morph macro Open
It is recommended that users of the aNMJ-morph macro are familiar with the original NMJ-morph workflow in a practical setting; please refer to the following publication for background details: "NMJ-morph reveals principal components of syn…
View article: Clinical Outcomes of Cervical Facet Fractures Treated Nonoperatively With Hard Collar or Halo Immobilization
Clinical Outcomes of Cervical Facet Fractures Treated Nonoperatively With Hard Collar or Halo Immobilization Open
Study Design: Retrospective review. Objectives: To evaluate the rate of nonoperative treatment failure for cervical facet fractures while secondarily validating computed tomography–based criteria proposed by Spector et al for identifying r…
View article: Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits.
Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits. Open
Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been…
View article: NMJ-morph reveals principal components of synaptic morphology influencing structure–function relationships at the neuromuscular junction
NMJ-morph reveals principal components of synaptic morphology influencing structure–function relationships at the neuromuscular junction Open
The ability to form synapses is one of the fundamental properties required by the mammalian nervous system to generate network connectivity. Structural and functional diversity among synaptic populations is a key hallmark of network divers…
View article: Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes
Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes Open
Rett syndrome (RTT) is a severe genetic disorder resulting from mutations in the X-linked MECP2 gene. MeCP2 protein is highly expressed in the nervous system and deficiency in the mouse central nervous system alone recapitulates many featu…