Ross A. McDevitt
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View article: Glycolytic activation of β-cell Na+/K+-ATPases containing β1-subunits accelerates Na+ extrusion, prolonging the duration of Ca2+ oscillations but decreasing insulin secretion
Glycolytic activation of β-cell Na+/K+-ATPases containing β1-subunits accelerates Na+ extrusion, prolonging the duration of Ca2+ oscillations but decreasing insulin secretion Open
Electrogenic Na+/K+ ATPases (NKAs) control β-cell Ca2+ influx and insulin secretion by integrating the signal strength of stimulatory G protein (Gs)-coupled ligands (e.g., GLP-1, glucagon) and inhibitory G protein (Gi)-coupled ligands (e.g…
View article: Midbrain extracellular matrix and microglia are associated with cognition in aging mice
Midbrain extracellular matrix and microglia are associated with cognition in aging mice Open
Synapse dysfunction is tightly linked to cognitive changes during aging. Emerging evidence suggests that microglia and the extracellular matrix (ECM) can potently regulate synapse integrity and plasticity. Yet the brain ECM, and its relati…
View article: Senolytic effects of a modified Gingerenone A
Senolytic effects of a modified Gingerenone A Open
Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of peop…
View article: Reducing <scp>HuD</scp> Levels Alleviates Alzheimer's Disease Pathology in <scp>5xFAD</scp> Mice
Reducing <span>HuD</span> Levels Alleviates Alzheimer's Disease Pathology in <span>5xFAD</span> Mice Open
Alzheimer's disease (AD) is the most common neurodegenerative pathology in older persons. The accumulation of amyloid β (Aβ) plaques is a major contributor to AD development. The RNA‐binding protein HuD/ELAVL4 has been implicated in the fo…
View article: Reduction of central arterial stiffness by senolytic quercetin improves age‐associated decline in cognitive function in a Dahl salt‐sensitive rat model of early vascular aging
Reduction of central arterial stiffness by senolytic quercetin improves age‐associated decline in cognitive function in a Dahl salt‐sensitive rat model of early vascular aging Open
Background Early vascular aging (EVA), manifesting as increases in central arterial stiffness and BP, is associated with cognitive impairment in humans. EVA and cognitive impairment occurs in Dahl salt‐sensitive (DSS) rats consuming a norm…
View article: Photobiomodulation Therapy Increases Brain Cortex Neuroprotective Gene Expression and Improves Motor Function in an APP/PS1 Male Mouse Model of Alzheimer’s Disease
Photobiomodulation Therapy Increases Brain Cortex Neuroprotective Gene Expression and Improves Motor Function in an APP/PS1 Male Mouse Model of Alzheimer’s Disease Open
Background Photobiomodulation (PBM) therapy, using low intensity near‐infrared light is a noninvasive form of treatment with no side effects can be used to treat Alzheimer’s disease (AD). In a double‐transgenic mouse model of AD (APPswe/PS…
View article: EXPLORING THE IMPACT OF INTERMITTENT HYPOXIA THROUGH A COMPREHENSIVE MULTI-OMICS APPROACH IN AGED MOUSE MODELS
EXPLORING THE IMPACT OF INTERMITTENT HYPOXIA THROUGH A COMPREHENSIVE MULTI-OMICS APPROACH IN AGED MOUSE MODELS Open
Comprehending aging’s molecular mechanisms, like RNA splicing and AMPK signaling, is vital for tackling age-related issues and boosting resilience. Oxygen fluctuations from obstructive sleep apnea (OSA) cause Intermittent Hypoxia (IH), aff…
View article: Extracellular matrix remodeling during aging aligns with synapse, microglia, and cognitive status
Extracellular matrix remodeling during aging aligns with synapse, microglia, and cognitive status Open
Synapse dysfunction is tightly linked to cognitive changes during aging, but underlying mechanisms driving dysfunction are minimally understood. The extracellular matrix (ECM) can potently regulate synapse integrity and plasticity. Yet the…
View article: Retraction Note: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
Retraction Note: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD Open
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13024-022-00564-6.
View article: Peripherally activated brain CD8+ T cells promote AD in 5xFAD mice
Peripherally activated brain CD8+ T cells promote AD in 5xFAD mice Open
The role of the adaptive immunity in Alzheimer’s Disease (AD) remains poorly understood. Recent findings from our group, which link B cells to manifestation AD 1, and others, which show increase of CD8+ T cells in the AD brain 2, suggest t…
View article: Cognitive performance is associated with cardiovascular and renal remodeling in young female rats with chronic kidney disease
Cognitive performance is associated with cardiovascular and renal remodeling in young female rats with chronic kidney disease Open
Background The prevalence of cognitive impairment (CI) and dementia in end‐stage chronic kidney disease (CKD) has been estimated at 30‐60%. Cardiovascular dysfunction accompanies CKD and contributes to CI in humans and animal models. Since…
View article: Chronic kidney disease is associated with cognitive dysfunction and cardiovascular remodeling in aged male and female Sprague‐Dawley rats
Chronic kidney disease is associated with cognitive dysfunction and cardiovascular remodeling in aged male and female Sprague‐Dawley rats Open
Background Cardiovascular diseases (CVD), including increased central arterial stiffness (CAS), accompany chronic kidney disease (CKD) development. An increase in pulse wave velocity (PWV), an index for CAS, is implicated in age‐associated…
View article: Effect of photobiological modulation therapy on cognitive impairment and cardiovascular structure in an APP/PS1 mouse model of Alzheimer’s Disease
Effect of photobiological modulation therapy on cognitive impairment and cardiovascular structure in an APP/PS1 mouse model of Alzheimer’s Disease Open
Background Photobiological modulation (PBM) therapy, a form of low‐dose light therapy, is beneficial in treating various disease conditions including Alzheimer’s disease (AD). Double‐transgenic mice (APPswe/PS1dE9) develop progressive accu…
View article: Microglial Nogo delays recovery following traumatic brain injury in mice
Microglial Nogo delays recovery following traumatic brain injury in mice Open
Nogo‐A, B, and C are well described members of the reticulon family of proteins, most well known for their negative regulatory effects on central nervous system (CNS) neurite outgrowth and repair following injury. Recent research indicates…
View article: Effects of Na/K‐ATPase Inhibitor Marinobufagenin on Gene Expression and Cognition in a Mouse Model of Alzheimer’s Disease
Effects of Na/K‐ATPase Inhibitor Marinobufagenin on Gene Expression and Cognition in a Mouse Model of Alzheimer’s Disease Open
Background Alzheimer’s disease (AD) is characterized by brain amyloid‐β plaque formation, neuroinflammation and neurodegeneration, which lead to cognitive impairment (CI) and disruption of circadian rhythm. Bioactive steroidal Na/K‐ATPase …
View article: Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity Open
The Topoisomerase 3B (Top3b) - Tudor domain containing 3 (Tdrd3) protein complex is the only dual-activity topoisomerase complex in animals that can alter the topology of both DNA and RNA. TOP3B mutations in humans are associated with schi…
View article: Loss of smelling is an early marker of aging and is associated with inflammation and <scp>DNA</scp> damage in <scp>C57BL</scp>/<scp>6J</scp> mice
Loss of smelling is an early marker of aging and is associated with inflammation and <span>DNA</span> damage in <span>C57BL</span>/<span>6J</span> mice Open
Olfactory dysfunction is a prevalent symptom and an early marker of age‐related neurodegenerative diseases in humans, including Alzheimer's and Parkinson's Diseases. However, as olfactory dysfunction is also a common symptom of normal agin…
View article: Cognitive impairment is associated with cardiovascular remodeling in the mouse model of Alzheimer’s disease
Cognitive impairment is associated with cardiovascular remodeling in the mouse model of Alzheimer’s disease Open
Background Double‐mutant mice (APPswe/PS1dE9; 2xTg‐AD) represent a model of Alzheimer’s disease (AD). 2xTg‐AD mice develop progressive accumulation of amyloid plaques and cognitive impairment (CI) with age in >12 months old animals. The ai…
View article: Treatment with losartan, an AT1 receptor blocker, improves cognitive and cardiovascular function in a Dahl salt‐sensitive rat model of age‐associated vascular dementia.
Treatment with losartan, an AT1 receptor blocker, improves cognitive and cardiovascular function in a Dahl salt‐sensitive rat model of age‐associated vascular dementia. Open
Background Dementia is characterized by progressive cognitive impairment (CI), which is accompanied by decline in reasoning, planning and memory. Cardiovascular diseases are the major contributors to the pathogenesis of vascular dementia a…
View article: Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes Open
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology dis…
View article: RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD
RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD Open
Background Although ɑ-synuclein (ɑ-syn) spreading in age-related neurodegenerative diseases such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) has been extensively investigated, the role of aging in the manifestation of d…
View article: A red nucleus–VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use
A red nucleus–VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use Open
Physical exercise is rewarding and protective against drug abuse and addiction. However, the neural mechanisms underlying these actions remain unclear. Here, we report that long-term wheel-running produced a more robust increase in c-fos e…
View article: Male rat leukocyte population dynamics predict a window for intervention in aging
Male rat leukocyte population dynamics predict a window for intervention in aging Open
Many age-associated changes in the human hematopoietic system have been reproduced in murine models; however, such changes have not been as robustly explored in rats despite the fact these larger rodents are more physiologically similar to…
View article: Author response: Male rat leukocyte population dynamics predict a window for intervention in aging
Author response: Male rat leukocyte population dynamics predict a window for intervention in aging Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Many age-associated cha…