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View article: GABA Neurons in the Amygdala play a central Role in Urocortin-3–Mediated Stress Suppression of Reproduction
GABA Neurons in the Amygdala play a central Role in Urocortin-3–Mediated Stress Suppression of Reproduction Open
Stress can disrupt menstrual cycles, cause infertility, and lead to other reproductive disorders. The posterodorsal medial amygdala (MePD) processes stress signals and regulates the gonadotropin-releasing hormone (GnRH) pulse generator thr…
View article: GABA Signaling in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice
GABA Signaling in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice Open
Psychological stress is linked to infertility by suppressing the hypothalamic GnRH pulse generator. The posterodorsal subnucleus of the medial amygdala (MePD) is an upstream regulator of GnRH pulse generator activity and displays increased…
View article: Traumatic Brain Injury Leads to Alterations in Contusional Cortical miRNAs Involved in Dementia
Traumatic Brain Injury Leads to Alterations in Contusional Cortical miRNAs Involved in Dementia Open
There is compelling evidence that head injury is a significant environmental risk factor for Alzheimer’s disease (AD) and that a history of traumatic brain injury (TBI) accelerates the onset of AD. Amyloid-β plaques and tau aggregates have…
View article: The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach
The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach Open
Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoinin-B and dynorphin. Here, using mathematical modeling and in …
View article: Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases LH pulse frequency in female mice
Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases LH pulse frequency in female mice Open
Kisspeptin within the arcuate nucleus of the hypothalamus is a critical neuropeptide in the regulation of reproduction. Together with neurokinin and dynorphin A, arcuate kisspeptin provides the oscillatory activity that drives the pulsatil…
View article: Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation
Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation Open
Summary Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons co-expressing kisspeptin, neurokoinin-B and dynorphin that drives the pulsatile release…