Ross N. P. Cahill
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View article: Tracking dendritic cells: use of an in situ method to label all blood leukocytes
Tracking dendritic cells: use of an in situ method to label all blood leukocytes Open
Here we describe an in situ procedure with a labeling index (percent of labeled blood leukocytes) >98%, which is high enough to permit the direct tracking of dendritic cell (DC) precursors from blood into lymphoid tissues, while circumvent…
View article: Neonatal thymectomy identifies two major pools of sessile and recirculating peripheral T cells which appear to be under separate homeostatic control
Neonatal thymectomy identifies two major pools of sessile and recirculating peripheral T cells which appear to be under separate homeostatic control Open
In this study the role of the thymus in the development of sessile T cell populations resident in spleen and lymph nodes (LN) was contrasted with the development of recirculating T cell populations trafficking between blood and lymph. Exte…
View article: Thymic export in aged sheep: a continuous role for the thymus throughout pre- and postnatal life
Thymic export in aged sheep: a continuous role for the thymus throughout pre- and postnatal life Open
A diverse repertoire among peripheral T cells is established in early life by thymic export when the naive T cell pool is first formed. In contrast, during adult life the thymus has been thought to play only a minor role in T cell homeosta…
View article: <scp>l</scp>‐selectin expression on thymic emigrants defines two distinct tissue‐migration pathways
<span>l</span>‐selectin expression on thymic emigrants defines two distinct tissue‐migration pathways Open
Summary We have studied the appearance and phenotype of recent thymic emigrants in blood, spleen and lymph nodes (LN) of neonatal lambs. Using in situ labelling of thymocytes with fluoroscein isothiocyanate (FITC), we examined the expressi…
View article: <b>Late‐term fetal thymectomy does not prevent the development of gut‐homing T cells after birth</b>
<b>Late‐term fetal thymectomy does not prevent the development of gut‐homing T cells after birth</b> Open
Tissue‐specific circulation of T cells is a critical element in the integration of systemic immune responses. Current models of T‐cell migration suggest that homing specificities of T cells for tissues such as gut and skin are generated ou…
View article: Antigen‐Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep
Antigen‐Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep Open
We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on αβ and γδ T cells emigrating from the fetal and postnatal thymus. We report that both γδ and the CD4 + CD8 - and CD4 - CD8 + subsets of αβ T cells express mature levels …
View article: Lymphocyte subset-specific and tissue-specific lymphocyte-endothelial cell recognition mechanisms independently direct the recirculation of lymphocytes from blood to lymph in sheep.
Lymphocyte subset-specific and tissue-specific lymphocyte-endothelial cell recognition mechanisms independently direct the recirculation of lymphocytes from blood to lymph in sheep. Open
Tissue-specific and lymphocyte subset-specific lymphocyte recirculation patterns have been analysed simultaneously. Lymphocytes obtained from one lymph compartment were directly labelled with fluorochrome in vitro and returned to the blood…
View article: Recirculation of lymphocyte subsets (CD5+, CD4+, CD8+, T19+ and B cells) through fetal lymph nodes.
Recirculation of lymphocyte subsets (CD5+, CD4+, CD8+, T19+ and B cells) through fetal lymph nodes. Open
The experiments reported in this paper examine the cell-surface phenotype (CD5, CD4, CD8, T19, MHC class II and sIg) and cell output of lymphocyte subsets circulating through a subcutaneous lymph node in the sheep fetus, in an environment …
View article: Recirculation of lymphocyte subsets (CD5+, CD4+, CD8+, SBU-T19+ and B cells) through gut and peripheral lymph nodes.
Recirculation of lymphocyte subsets (CD5+, CD4+, CD8+, SBU-T19+ and B cells) through gut and peripheral lymph nodes. Open
The surface phenotypes (CD5+, CD4+, CD8+, SBU-T19+, MHC class II+, T80+ and sIg+) of lymphocytes in blood, and in prescapular and ileocaecal efferent lymph of sheep, have been determined. The similarity in the distribution of lymphocyte su…
View article: Uptake and degradation of hyaluronan in lymphatic tissue
Uptake and degradation of hyaluronan in lymphatic tissue Open
Afferent lymph vessels entering popliteal lymph nodes of sheep were infused with [3H]acetyl-labelled hyaluronan of high Mr (4.3 x 10(6)-5.5 x 10(6)) and low Mr (1.5 x 10(5)). Analysis of efferent lymph and of residues in the nodes showed t…
View article: Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes.
Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes. Open
The surface phenotypes (CD1, CD4, CD5, CD8, SBU-T19, MHC class I, MHC class II, and sIg) of cells in blood, lymph nodes, and lymph were determined to examine simultaneously the distribution of lymphocyte subsets circulating in blood, affer…
View article: Concentration and relative molecular mass of hyaluronate in lymph and blood
Concentration and relative molecular mass of hyaluronate in lymph and blood Open
Human lymph was collected from patients with leaking lymph vessels after thoracic surgery. Ovine lymph was obtained from the mesenteric, lumbar, popliteal and prescapular lymph ducts by cannulation. The concentration of hyaluronate varied …
View article: Inhibin secretion by the sheep ovary
Inhibin secretion by the sheep ovary Open
An in-vitro bioassay for inhibin based on FSH content or release by rat pituitary cells was validated for measuring inhibin activity in ovine plasma and lymph. Dose-dependent increases in inhibin activity were detected in peripheral plasma…
View article: Essential Fatty Acids in the Fetal and Newborn Lamb
Essential Fatty Acids in the Fetal and Newborn Lamb Open
The concentrations of linoleic and linolenic acids and their metabolites in the liver, kidney, brain, erythrocytes and plasma of fetal lambs at various stages of gestation, and of newborn and 2-week-01d suckled lambs was determined. Throug…
View article: Studies on the differentiation of T lymphocytes in sheep. I. Recognition of a sheep T-lymphocyte differentiation antigen by a monoclonal antibody T-80.
Studies on the differentiation of T lymphocytes in sheep. I. Recognition of a sheep T-lymphocyte differentiation antigen by a monoclonal antibody T-80. Open
The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes …
View article: The appearance of non-specific antibody-forming cells in the efferent lymph draining antigen-stimulated single lymph nodes.
The appearance of non-specific antibody-forming cells in the efferent lymph draining antigen-stimulated single lymph nodes. Open
Immunization of single lymph nodes with various antigens led to the appearance of cells in the efferent lymph that secreted antibody specific for the antigen which induced their formation and for a number of unrelated, non-crossreacting an…
View article: Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes.
Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes. Open
A pronounced asymmetry in the recirculation from blood to lymph of resting small recirculating T lymphocytes is described. When 51Cr-labeled small T-recirculating lymphocytes (TRL) from intestinal lymph were infused intravenously their rel…
View article: The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes.
The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes. Open
The increased input of RL into LN starts within 3 h after antigenic stimulation and is due to an increase in the number of RL passing through a LN. It is not associated with an altered transit time through a LN of the majority of RL and it…