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View article: Sex-related differences in pulmonary arterial-right ventricular coupling during exercise doppler echocardiography among patients with connective tissue disease: insights from the RIGHT-NET
Sex-related differences in pulmonary arterial-right ventricular coupling during exercise doppler echocardiography among patients with connective tissue disease: insights from the RIGHT-NET Open
Background and Aims Connective Tissue Diseases (CTD) are associated with severe cardiovascular and pulmonary complications. Right ventricular-pulmonary arterial coupling (RVPAC) plays a critical role in prognosis, yet the sex-based differe…
View article: A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: a machine learning approach
A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: a machine learning approach Open
Background Pulmonary hypertension (PH) is a pathophysiological problem that may involve several clinical symptoms and be linked to various respiratory and cardiovascular illnesses. Its diagnosis is made invasively by Right Cardiac Catheter…
View article: PCSK9 Inhibitors “Fast Track” Use Versus “Stepwise” Lipid-Lowering Therapy in Patients with Acute Coronary Syndrome: A Retrospective Single-Center Study in a “Real-World” Population
PCSK9 Inhibitors “Fast Track” Use Versus “Stepwise” Lipid-Lowering Therapy in Patients with Acute Coronary Syndrome: A Retrospective Single-Center Study in a “Real-World” Population Open
Background: The “fast track” addition (within 48 h) of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) to the optimized oral lipid-lowering therapy (LLT) during hospitalization for acute coronary syndrome (ACS) has been s…
View article: Exercise Echocardiography of Left Ventricular Diastolic Function in Healthy Subjects: Insights From the RIGHT-NET
Exercise Echocardiography of Left Ventricular Diastolic Function in Healthy Subjects: Insights From the RIGHT-NET Open
In healthy adult subjects, E/e' slightly increased during midlevel exercise. Both E/e' and TRV are exercise intensity-dependent and would therefore be better expressed as a function of CO for the diagnosis of normal vs abnormal LV diastoli…
View article: A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: A machine learning approach
A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: A machine learning approach Open
The PH-targeted ML models could streamline routine screening for PH, facilitating earlier identification and better RHC referrals.
View article: Risk score model to automatically detect prostate cancer patients by integrating diagnostic parameters
Risk score model to automatically detect prostate cancer patients by integrating diagnostic parameters Open
Introduction Prostate cancer (PCa) is one of the prevailing forms of cancer among men. At present, multiparametric MRI is the imaging method for localizing tumors and staging cancer. Radiomics plays a key role and hold potential for PCa de…
View article: Are the variations in ECG morphology associated to different blood glucose levels? implications for non-invasive glucose monitoring for T1D paediatric patients
Are the variations in ECG morphology associated to different blood glucose levels? implications for non-invasive glucose monitoring for T1D paediatric patients Open
View article: A Self-Attention Deep Neural Network Regressor for real time blood glucose estimation in paediatric population using physiological signals
A Self-Attention Deep Neural Network Regressor for real time blood glucose estimation in paediatric population using physiological signals Open
View article: A smartphone-based tool for screening diabetic neuropathies: A mHealth and 3D printing approach
A smartphone-based tool for screening diabetic neuropathies: A mHealth and 3D printing approach Open
View article: Health-related quality of life in patients with aortic dissection: An unmet need
Health-related quality of life in patients with aortic dissection: An unmet need Open
Knowledge about the Health-related Quality of Life (HR-QoL) after Type A (TA-AAD) and Type B acute aortic dissection (TB-AAD) is still insufficient. Through this systematic review, including 22 studies (16 for TA-AAD and 6 TB-AAD -1998-202…
View article: Estimation of ECG Parameters via Deep Learning based ECG Segmentation Tool for Non-invasive Detection of Glycaemic Events
Estimation of ECG Parameters via Deep Learning based ECG Segmentation Tool for Non-invasive Detection of Glycaemic Events Open
The ECG segmentation tool has been pivotal in determination of fidu-cial points of the ECG beat which can be used to determine the ECG parameters representing the ECG beat and short-term ECG signal. Most of existing studies suggest the fil…
View article: Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment
Cardiovascular Side Effects of Anthracyclines and HER2 Inhibitors among Patients with Breast Cancer: A Multidisciplinary Stepwise Approach for Prevention, Early Detection, and Treatment Open
Cardiovascular (CV) diseases (CVD) are a major cause of long-term morbidity and mortality affecting life expectancy amongst cancer survivors. In recent years, because of the possibility of early diagnosis and the increased efficacy of neo-…
View article: Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways
Exploring the Cardiotoxicity Spectrum of Anti-Cancer Treatments: Definition, Classification, and Diagnostic Pathways Open
Early detection and treatment of cancer have led to a noticeable reduction in both mortality and morbidity. However, chemotherapy and radiotherapy could exert cardiovascular (CV) side effects, impacting survival and quality of life, indepe…
View article: Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide
Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide Open
Acute heart failure (AHF) is the most frequent cause of unplanned hospital admission in patients of >65 years of age and it is associated with significantly increased morbidity, mortality, and healthcare costs. Different AHF classification…
View article: A Framework of Analysis to Facilitate the Harmonization of Multicenter Radiomic Features in Prostate Cancer
A Framework of Analysis to Facilitate the Harmonization of Multicenter Radiomic Features in Prostate Cancer Open
Pooling radiomic features coming from different centers in a statistical framework is challenging due to the variability in scanner models, acquisition protocols, and reconstruction settings. To remove technical variability, commonly calle…
View article: Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age
Physiologic Range of Myocardial Mechano-Energetic Efficiency among Healthy Subjects: Impact of Gender and Age Open
Background: Myocardial mechano-energetic efficiency (MEE) is the capability of the left ventricle (LV) to convert the chemical energy obtained from the cardiac oxidative metabolism into mechanical work. The aim of present study was to esta…
View article: A Complex Radiomic Signature in Luminal Breast Cancer from a Weighted Statistical Framework: A Pilot Study
A Complex Radiomic Signature in Luminal Breast Cancer from a Weighted Statistical Framework: A Pilot Study Open
Radiomics is rapidly advancing in precision diagnostics and cancer treatment. However, there are several challenges that need to be addressed before translation to clinical use. This study presents an ad-hoc weighted statistical framework …
View article: The use of artificial intelligence systems in diagnosis of pneumonia via signs and symptoms: A systematic review
The use of artificial intelligence systems in diagnosis of pneumonia via signs and symptoms: A systematic review Open
Artificial Intelligence (AI) systems using symptoms/signs to detect respiratory diseases may improve diagnosis especially in limited resource settings. Heterogeneity in such AI systems creates an ongoing need to analyse performance to info…
View article: STEMI-PCI incidence rates and outcomes during COVID-19 pandemic: insights from Cardarelli Hospital, Naples, Southern Italy
STEMI-PCI incidence rates and outcomes during COVID-19 pandemic: insights from Cardarelli Hospital, Naples, Southern Italy Open
From January 2020, the COVID-19 has become a globally health emergency, so the World Health Organization (WHO) declared the pandemic infection on 11 March 2020. 1 During COVID-19 outbreak, hospital admissions have been declining for non-CO…
View article: A machine learning model for supporting symptom-based referral and diagnosis of bronchitis and pneumonia in limited resource settings
A machine learning model for supporting symptom-based referral and diagnosis of bronchitis and pneumonia in limited resource settings Open
View article: A framework for designing medical devices resilient to low-resource settings
A framework for designing medical devices resilient to low-resource settings Open
View article: PET/MRI for staging patients with Hodgkin lymphoma: equivalent results with PET/CT in a prospective trial
PET/MRI for staging patients with Hodgkin lymphoma: equivalent results with PET/CT in a prospective trial Open
View article: Radiomic and Genomic Machine Learning Method Performance for Prostate Cancer Diagnosis: Systematic Literature Review
Radiomic and Genomic Machine Learning Method Performance for Prostate Cancer Diagnosis: Systematic Literature Review Open
Background Machine learning algorithms have been drawing attention at the joining of pathology and radiology in prostate cancer research. However, due to their algorithmic learning complexity and the variability of their architecture, ther…
View article: MuSA: a graphical user interface for multi-OMICs data integration in radiogenomic studies
MuSA: a graphical user interface for multi-OMICs data integration in radiogenomic studies Open
Analysis of large-scale omics data along with biomedical images has gaining a huge interest in predicting phenotypic conditions towards personalized medicine. Multiple layers of investigations such as genomics, transcriptomics and proteomi…
View article: Impact of Breast Tumor Onset on Blood Count, Carcinoembryonic Antigen, Cancer Antigen 15-3 and Lymphoid Subpopulations Supported by Automatic Classification Approach: A Pilot Study
Impact of Breast Tumor Onset on Blood Count, Carcinoembryonic Antigen, Cancer Antigen 15-3 and Lymphoid Subpopulations Supported by Automatic Classification Approach: A Pilot Study Open
Background Recent observations showed that systemic immune changes are detectable in case of breast cancer (BC). In this preliminary study, we investigated routinely measured peripheral blood (PB) parameters for malignant BC cases in compa…
View article: Additional file 3 of A framework for designing medical devices resilient to low-resource settings
Additional file 3 of A framework for designing medical devices resilient to low-resource settings Open
Additional file 3. is an Excel file (.xlsx) and is the tool that was used for validating the framework and that can be used for assessing other technologies.
View article: Supplementary Material for: DNA Methylation Profile of the <b><i>SREBF2</i></b> Gene in Human Fetal Aortas
Supplementary Material for: DNA Methylation Profile of the <b><i>SREBF2</i></b> Gene in Human Fetal Aortas Open
Increasing evidence suggests that maternal cholesterol represents an important risk factor for atherosclerotic disease in offspring already during pregnancy, although the underlying mechanisms have not yet been elucidated. Eighteen human f…
View article: Detection of melatonin-onset in real settings via wearable sensors and artificial intelligence. A pilot study
Detection of melatonin-onset in real settings via wearable sensors and artificial intelligence. A pilot study Open
Circadian rhythms modulate physiological and behavioral processes of approximately 24-h periodicity. Alterations in the circadian timing system may lead to cardiovascular, metabolic or neurological diseases, cancers and sleep disorders, as…
View article: An Integrative Computational Approach Based on Expression Similarity Signatures to Identify Protein–Protein Interaction Networks in Female-Specific Cancers
An Integrative Computational Approach Based on Expression Similarity Signatures to Identify Protein–Protein Interaction Networks in Female-Specific Cancers Open
Breast, ovarian, and endometrial cancers have a major impact on mortality in women. These tumors share hormone-dependent mechanisms involved in female-specific cancers which support tumor growth in a different manner. Integrated computatio…
View article: Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study
Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study Open
Reduced levels of circulating HLA-G molecules could derive from epigenetic marks. Epigenetics phenomena induce hypomethylation of specific regions into 5'UTR-CpG island of HLA-G gene in CHD patients with obstructive non critical stenosis v…