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View article: Inhibition of Unc-51-like-kinase is mitoprotective during <i>Pseudomonas aeruginosa</i> infection in corneal epithelial cells
Inhibition of Unc-51-like-kinase is mitoprotective during <i>Pseudomonas aeruginosa</i> infection in corneal epithelial cells Open
Pseudomonas aeruginosa (PA) is an opportunistic gram-negative pathogen that can infect the cornea, leading to permanent vision loss. Autophagy is a cannibalistic process that drives cytoplasmic components to the lysosome for degradation an…
View article: Ebola Virus Uses Tunneling Nanotubes as an Alternate Route of Dissemination
Ebola Virus Uses Tunneling Nanotubes as an Alternate Route of Dissemination Open
Ebola virus (EBOV) disease is marked by rapid virus replication and spread. EBOV enters the cell by macropinocytosis and replicates in the cytoplasm, and nascent virions egress from the cell surface to infect neighboring cells. Here, we sh…
View article: Isolation, Characterization, and Autophagy Function of BECN1-Splicing Isoforms in Cancer Cells
Isolation, Characterization, and Autophagy Function of BECN1-Splicing Isoforms in Cancer Cells Open
Alternative splicing allows the synthesis of different protein variants starting from a single gene. Human Beclin 1 (BECN1) is a key autophagy regulator that acts as haploinsufficient tumor suppressor since its decreased expression correla…
View article: A Molecular Analysis of Neural Olfactory Placode Differentiation in Human Pluripotent Stem Cells
A Molecular Analysis of Neural Olfactory Placode Differentiation in Human Pluripotent Stem Cells Open
During embryonic development, the olfactory sensory neurons (OSNs) and the gonadotropic-releasing hormone neurons (GNRHNs) migrate from the early nasal cavity, known as the olfactory placode, to the brain. Defects in the development of OSN…
View article: IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium
IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium Open
These findings indicate that IGFBP-3 is a critical protein involved in hyperosmolar stress responses in the corneal epithelium. These data further support a new role for IGFBP-3 in the control of cellular metabolism.
View article: Tear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea
Tear Levels of IGFBP-3: A Potential Biomarker for Diabetic Nerve Changes in the Cornea Open
Introduction: Type 2 diabetes mellitus has reached epidemic levels in the United States and worldwide. Ocular complications from this disease include diabetic retinopathy and keratopathy, both of which can lead to significant vision loss. …
View article: The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease
The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease Open
The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracti…
View article: Insulin receptor preserves mitochondrial function by binding VDAC1 in insulin insensitive mucosal epithelial cells
Insulin receptor preserves mitochondrial function by binding VDAC1 in insulin insensitive mucosal epithelial cells Open
Unlike many epithelial tissues, the corneal epithelium is insulin insensitive, meaning it does not require insulin for glucose uptake. In this study, we show that insulin differentially regulates mitochondrial respiration in two human muco…
View article: Starvation Promotes Autophagy-Associated Maturation of the Testis in the Giant Freshwater Prawn, Macrobrachium rosenbergii
Starvation Promotes Autophagy-Associated Maturation of the Testis in the Giant Freshwater Prawn, Macrobrachium rosenbergii Open
Autophagy is a degradative process of cellular components accomplished through an autophagosomal-lysosomal pathway. It is an evolutionary conserved mechanism present in all eukaryotic cells, and it plays a fundamental role in maintaining t…
View article: Mutual regulation between IGF‐1R and IGFBP‐3 in human corneal epithelial cells
Mutual regulation between IGF‐1R and IGFBP‐3 in human corneal epithelial cells Open
The insulin‐like growth factor type 1 receptor (IGF‐1R) is part of the receptor tyrosine kinase superfamily. The activation of IGF‐1R regulates several key signaling pathways responsible for maintaining cellular homeostasis, including surv…
View article: Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells
Insulin mediates de novo nuclear accumulation of the IGF-1/insulin Hybrid Receptor in corneal epithelial cells Open
Insulin and insulin-like growth factor-1 (IGF-1) are present in human tears and likely play an important role in mediating ocular surface homeostasis. We previously characterized the IGF-1/insulin hybrid receptor (Hybrid–R) in corneal epit…
View article: Tear Levels of Insulin-Like Growth Factor Binding Protein 3 Correlate With Subbasal Nerve Plexus Changes in Patients With Type 2 Diabetes Mellitus
Tear Levels of Insulin-Like Growth Factor Binding Protein 3 Correlate With Subbasal Nerve Plexus Changes in Patients With Type 2 Diabetes Mellitus Open
These findings indicate that tear levels of IGFBP-3 are more tightly correlated to nerve fiber changes in diabetes than HbA1c. Future studies that stratify the severity of diabetic disease with tear levels of IGFBP-3 are needed to validate…
View article: The metabolic cross‐talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: Autophagy plays a role
The metabolic cross‐talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: Autophagy plays a role Open
Cancer and stromal cells, which include (cancer‐associated) fibroblasts, adipocytes, and immune cells, constitute a mixed cellular ecosystem that dynamically influences the behavior of each component, creating conditions that ultimately fa…
View article: Starvation Promotes Autophagy-Associated Maturation of the Ovary in the Giant Freshwater Prawn, Macrobrachium rosenbergii
Starvation Promotes Autophagy-Associated Maturation of the Ovary in the Giant Freshwater Prawn, Macrobrachium rosenbergii Open
Limitation of food availability (starvation) is known to influence the reproductive ability of animals. Autophagy is a lysosomal driven degradation process that protects the cell under metabolic stress conditions, such as during nutrient s…