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Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease Open

Javier María Peralta Ramos, Giulia Castellani, Denise Kviatcovsky, Tommaso Croese, Afroditi Tsitsou-Kampeli , et al. · 2025

Protective immunity, essential for brain maintenance and repair, may be compromised in Alzheimer's disease (AD). Here, using high-dimensional single-cell mass cytometry, we find a unique immunometabolic signature in circulating CD4⁺

Early basal ganglia imaging abnormalities in pre‐symptomatic and early symptomatic novel APP duplication carriers Open

Rotem Paz, Eyal Bergmann, Ayelet Eran, Yael Rozen, Sapir Golan , et al. · 2024

Background We aim to describe the imaging findings in pre‐symptomatic and early‐symptomatic individuals carrying a recently described novel APP duplication rearrangement causing early‐onset AD (EOAD). Method We studied individuals from one…

Familial Early-Onset Alzheimer's Caused by Novel Genetic Variant and <i>APP</i> Duplication Open

Limor Kalfon, Rotem Paz, Hadas Raveh-Barak, Areef Salama, Nadra Nasser Samra , et al. · 2020

P2‐489: CHARACTERIZING COGNITIVE AND NEURAL ALTERATIONS AMONG HEALTHY PARTICIPANTS WITH A GENETIC PREDISPOSITION FOR ALZHEIMER'S DISEASE Open

Rotem Paz, Tzipora C. Falik‐Zaccai, Judith Aharon‐Peretz, Itamar Kahn · 2018

Detecting subtle alterations among genetically at risk population for developing Alzheimer's Disease (AD), in presymptomatic stages will open a time window for intervention and prevention. It is now acknowledged that in order to arrest or …

Early Age-Related Functional Connectivity Decline in High-Order Cognitive Networks Open

Tali Siman-Tov, Noam Bosak, Elliot Sprecher, Rotem Paz, Ayelet Eran , et al. · 2017

As the world ages, it becomes urgent to unravel the mechanisms underlying brain aging and find ways of intervening with them. While for decades cognitive aging has been related to localized brain changes, growing attention is now being pai…