Ying Chen
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View article: Quercetin-Fe nanodots inhibit cervical cancer cell proliferation by targeting PCNA
Quercetin-Fe nanodots inhibit cervical cancer cell proliferation by targeting PCNA Open
The online version contains supplementary material available at 10.1186/s12645-025-00353-y.
View article: A Pharmacovigilance Study of Immune Checkpoint Inhibitor‐Associated Cholangitis: Insights From the FDA Adverse Event Reporting System
A Pharmacovigilance Study of Immune Checkpoint Inhibitor‐Associated Cholangitis: Insights From the FDA Adverse Event Reporting System Open
Aim Immune checkpoint inhibitor (ICI)‐associated cholangitis is a rare immune‐related adverse event (irAE). However, large‐scale clinical studies specifically investigating this toxicity are still lacking. The aim was to describe ICI‐assoc…
View article: Shade and Fabric Mulching Drive Variation in Medicinal Compounds and Rhizosphere Bacterial Communities in Epimedium sagittatum
Shade and Fabric Mulching Drive Variation in Medicinal Compounds and Rhizosphere Bacterial Communities in Epimedium sagittatum Open
This study investigated the interactive effects of different light conditions and weed control methods on the medicinal compound composition and rhizosphere bacterial community structure of Epimedium sagittatum. A completely randomized blo…
View article: Automating Antibody Cocktail Preparation and Sample Staining with the C-FREE Pluto LT system 9074
Automating Antibody Cocktail Preparation and Sample Staining with the C-FREE Pluto LT system 9074 Open
Description The preparation of antibody cocktails for flow cytometry, especially for intracellular staining, is time-consuming and prone to variability. The C-FREE Pluto system offers an automated solution to streamline this process, reduc…
View article: Investigating Pragmatic Competence of China’s Ethic Minority EFL Learners in Cross-Cultural Communication: A CSE-based Study
Investigating Pragmatic Competence of China’s Ethic Minority EFL Learners in Cross-Cultural Communication: A CSE-based Study Open
Pragmatic competence has been quite an important issue in cross-cultural communication and has been one of the most significant objectives of EFL learning and teaching. There have been some important studies on the pragmatic competence of …
View article: Impact of rare EGFR exon 19 insertion–deletion variants on tyrosine kinase inhibitor efficacy in non-small-cell lung cancer: a 5-year multicenter analysis
Impact of rare EGFR exon 19 insertion–deletion variants on tyrosine kinase inhibitor efficacy in non-small-cell lung cancer: a 5-year multicenter analysis Open
First-generation TKIs represent a potential initial option for EGFR 19delins-mutant LUAD. Proactive later-line strategies, including osimertinib and immunotherapy, optimize survival. Subtype-driven management is critical for this rare popu…
View article: Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients
Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients Open
Baseline p11 levels may serve as a peripheral blood biomarker for female depressive patients and further provide more insight into the pathological mechanisms of MDD.
View article: 16S rDNA sequencing and targeted metabolomics reveal rhizosphere microbial diversity and flavonoid dynamics in Scutellaria baicalensis Georgi
16S rDNA sequencing and targeted metabolomics reveal rhizosphere microbial diversity and flavonoid dynamics in Scutellaria baicalensis Georgi Open
The results suggest that flavonoid accumulation in S. baicalensis may be influenced by soil physicochemical properties and rhizosphere microorganisms, providing a valuable basis for future research on optimizing cultivation practices.
View article: A pharmacovigilance study of immune checkpoint inhibitor-associated cholangitis using the Food and Drug Administration adverse event reporting system
A pharmacovigilance study of immune checkpoint inhibitor-associated cholangitis using the Food and Drug Administration adverse event reporting system Open
Background Immune checkpoint inhibitor (ICI)-associated cholangitis is a rare immune-related adverse event (irAE). However, large-scale clinical studies specifically investigating this toxicity are still lacking. This study aimed to descri…
View article: Concurrent Use of Kidney Replacement Therapy and Temporary Left Ventricular Assist Device in Cardiogenic Shock: A Systematic Review and Meta-Analysis
Concurrent Use of Kidney Replacement Therapy and Temporary Left Ventricular Assist Device in Cardiogenic Shock: A Systematic Review and Meta-Analysis Open
Introduction: The use of temporary-left ventricular assist devices (T-LVADs) for circulatory support in cardiogenic shock is increasing along with complications like acute kidney injury requiring kidney replacement therapy (KRT). While KRT…
View article: Machine learning models for predicting in-hospital mortality from acute pancreatitis in intensive care unit
Machine learning models for predicting in-hospital mortality from acute pancreatitis in intensive care unit Open
ML models have shown promising reliability in predicting in-hospital mortality among patients with AP in the ICU. Among these models, the CatBoost model exhibits superior predictive performance, providing valuable assistance to clinical pr…
View article: Comparative Analysis of Clinical Characteristics in Multi-organ and Single-organ Involvement of IgG4-Related Disease: A Single-center Retrospective Study
Comparative Analysis of Clinical Characteristics in Multi-organ and Single-organ Involvement of IgG4-Related Disease: A Single-center Retrospective Study Open
Background: Immunoglobulin G4-related disease (IgG4-RD) is a rare, chronic inflammatory condition characterized by fibrosis and tendency for multi-organ involvement. This study aims to analyze the clinical characteristics associated with m…
View article: Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing
Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing Open
Necrotizing enterocolitis (NEC) is an acute intestine dysfunction intestinal disorder characterized by inflammation and cell death, including pyroptosis. Previous studies have implicated pyroptosis, particularly via NLRP3 inflammatory acti…
View article: Streamlining Operational Efficiency Through Inter-organizational Business Network in Beijing, China
Streamlining Operational Efficiency Through Inter-organizational Business Network in Beijing, China Open
This study investigates the relationship between inter-organizational business networks and operational efficiency among 300 employees across various industries in Beijing, China. Using a quantitative comparative correlational design, the …
View article: Use of tranexamic acid in hepatectomy under controlled low central venous pressure: a randomized controlled study
Use of tranexamic acid in hepatectomy under controlled low central venous pressure: a randomized controlled study Open
The use of TXA in hepatectomy under CLCVP reduced the intraoperative blood transfusion rate and improved the postoperative bleeding outcome without increasing the risk of adverse events such as hepatic and renal insufficiency and thrombosi…
View article: Acoustic characterization of internal leakage in safety valves based on large eddy simulation and Möhring acoustic analogy
Acoustic characterization of internal leakage in safety valves based on large eddy simulation and Möhring acoustic analogy Open
Safety valves are important overpressure protection devices in nuclear power regulators and main steam systems, and internal leakage is one of the most common forms of failure. The LES/Möhring acoustic analog method is used to study the ac…
View article: The Effect of Acupoint Sticking Therapy on Serum Estrogen Levels and Endometrial Polyp Tissue Receptor Expression in Postmenopausal Patients With Endometrial Polyps
The Effect of Acupoint Sticking Therapy on Serum Estrogen Levels and Endometrial Polyp Tissue Receptor Expression in Postmenopausal Patients With Endometrial Polyps Open
Background Postmenopausal women with endometrial polyps (EPs) often experience hormonal imbalances. Acupoint application, a traditional Chinese medicine (TCM) approach, shows the potential to influence hormonal levels. This study investiga…
View article: Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2
Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 Open
Immunodeficiency, centromeric instability, and facial anomalies syndrome (ICF) is a rare genetic disease characterized by hypogammaglobulinemia, T cell immune deficiency with age, pericentromeric hypomethylation, facial abnormalities, and …
View article: Conserved Nuclear Localization Signal in NS2 Protein of Bombyx Mori Bidensovirus: A Potential Invertebrate ssDNA Virus Trait
Conserved Nuclear Localization Signal in NS2 Protein of Bombyx Mori Bidensovirus: A Potential Invertebrate ssDNA Virus Trait Open
Bombyx mori bidensovirus (BmBDV), a significant pathogen in the sericulture industry, holds a unique taxonomic position due to its distinct segmented single-stranded DNA (ssDNA) genome and the presence of a self-encoding DNA polymerase. Ho…
View article: Isoform-level discovery, quantification and fusion analysis from single-cell and spatial long-read RNA-seq data with Bambu-Clump
Isoform-level discovery, quantification and fusion analysis from single-cell and spatial long-read RNA-seq data with Bambu-Clump Open
Single cell and spatial transcriptomics have dramatically changed how we can profile RNA from heterogenous biological samples. Combining single cell and spatial profiling with long read RNA-Seq promises to enable the discovery and quantifi…
View article: A CASE OF MASSIVE PERICARDIAL EFFUSION IN SUBCLINICAL HYPOTHYROIDISM
A CASE OF MASSIVE PERICARDIAL EFFUSION IN SUBCLINICAL HYPOTHYROIDISM Open
INTRODUCTION/BACKGROUNDHypothyroidism is associated with multiorgan involvement and various complications. Pericardial effusion is a rare complication of hypothyroidism. However, if left untreated, it may progress to critical, life-threate…
View article: 16S rRNA sequencing and Targeted Metabolomics Analyses Reveal Rhizosphere Microbial Diversity and Flavonoids Dynamics in Scutellaria baicalensis Georgi
16S rRNA sequencing and Targeted Metabolomics Analyses Reveal Rhizosphere Microbial Diversity and Flavonoids Dynamics in Scutellaria baicalensis Georgi Open
Aims Scutellaria baicalensis Georgi is a commonly used bulk Chinese medicinal material in China. Clinically, it is often divided into Ziqin and Kuqin respectively into medicine, and herbal research and pharmacological studies have shown th…