Roumen Milev
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View article: Oral Methods of Microbiota Manipulation for Depression Symptoms: A Systematic Review: Méthodes orales de manipulation du microbiote pour traiter les symptômes de dépression : Une revue systématique
Oral Methods of Microbiota Manipulation for Depression Symptoms: A Systematic Review: Méthodes orales de manipulation du microbiote pour traiter les symptômes de dépression : Une revue systématique Open
Objective The effectiveness of current treatment options for depressive symptoms has been widely investigated with acknowledgment that some patients were either not adequately responding to treatment, finding the existing treatment intoler…
View article: The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau canadien pour le traitement des troubles de l’humeur et de l’anxiété (Canadian Network for Mood and Anxiety Treatments, CANMAT) concernant l’utilisation des probiotiques, des prébiotiques, des symbiotiques et de la transplantation de microbiote fécal chez les adultes atteints de trouble dépressif majeur
The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau canadien pour le traitement des troubles de l’humeur et de l’anxiété (Canadian Network for Mood and Anxiety Treatments, CANMAT) concernant l’utilisation des probiotiques, des prébiotiques, des symbiotiques et de la transplantation de microbiote fécal chez les adultes atteints de trouble dépressif majeur Open
Background Approximately one-third of adults with major depressive disorder (MDD) experience limited response or intolerable side effects with existing pharmacotherapies. As such, innovative treatments targeting novel biological pathways a…
View article: Socioeconomic status is associated with reward processing, interleukin 1β, striatal connectivity and antidepressant outcomes in individuals with major depressive disorder: A CAN-BIND-1 report.
Socioeconomic status is associated with reward processing, interleukin 1β, striatal connectivity and antidepressant outcomes in individuals with major depressive disorder: A CAN-BIND-1 report. Open
View article: Investigating Intrusive and Deliberate Rumination as Mediators in the Effects of Perceived Stress on Depression and Anxiety Severity
Investigating Intrusive and Deliberate Rumination as Mediators in the Effects of Perceived Stress on Depression and Anxiety Severity Open
Rumination, a form of self-relevant repetitive thought, can manifest after stressful experiences and exacerbate symptoms of psychopathology. Intrusive rumination (IR) but not deliberate rumination (DR) has been previously shown to mediate …
View article: Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression
Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression Open
Importance The limited success of major depressive disorder (MDD) treatments is largely due to the disorder’s etiological and pathophysiological heterogeneity. Addressing this heterogeneity is essential for developing accurate prognostic m…
View article: Standardized EEG for multi-site biomarker-informed trials: Implementation in the Canadian Biomarker Integration Network in Depression
Standardized EEG for multi-site biomarker-informed trials: Implementation in the Canadian Biomarker Integration Network in Depression Open
Our study offers comprehensive solutions for EEG practices across multiple sites, providing valuable insights and inspiration for establishing standardization approaches in collaborative neuroimaging efforts beyond depression research.
View article: Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study: Prédire la rechute d’épisodes dépressifs pendant le traitement d’entretien : Une étude de suivi du bien-être dans les troubles dépressifs majeurs du Réseau canadien d’intégration des biomarqueurs pour la dépression (CAN-BIND)
Predicting Relapse of Depressive Episodes During Maintenance Treatment: The Canadian Biomarker Integration Network in Depression (CAN-BIND) Wellness Monitoring in Major Depressive Disorder Study: Prédire la rechute d’épisodes dépressifs pendant le traitement d’entretien : Une étude de suivi du bien-être dans les troubles dépressifs majeurs du Réseau canadien d’intégration des biomarqueurs pour la dépression (CAN-BIND) Open
Background Relapse rates in major depressive disorder (MDD) remain high even after treatment to remission. Identifying predictors of relapse is, therefore, crucial for improving maintenance strategies and preventing future episodes. Remote…
View article: Omnibus Rumination Inventories Consistently Reveal Unconstructive, Constructive, and Positive Repetitive Thought as Rumination's Major Factors
Omnibus Rumination Inventories Consistently Reveal Unconstructive, Constructive, and Positive Repetitive Thought as Rumination's Major Factors Open
Numerous questionnaires and scales have been developed to measure trait rumination and related constructs (e.g., perseverative cognition, self-preoccupation, repetitive thought, etc.) over the past three decades. These tools measure variou…
View article: Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des résultats du traitement antidépresseur à l’aide des scores de risque polygéniques : Rapport sur l’étude CAN-BIND-1
Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des résultats du traitement antidépresseur à l’aide des scores de risque polygéniques : Rapport sur l’étude CAN-BIND-1 Open
Objective The genetic architecture of antidepressant response is poorly understood. This study investigated whether polygenic risk scores (PRSs) for major psychiatric disorders and a personality trait (neuroticism) are associated with anti…
View article: Treatment and long-term outcome of mental disorders: The grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries
Treatment and long-term outcome of mental disorders: The grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries Open
In the community, the overwhelming majority of mental patients do not receive appropriate treatment or, even worse, no treatment at all. The outcome is unfavourable for the majority and only a few selective treatment options seem to make a…
View article: The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression – A Phase 2, Double-Blind, Placebo-Controlled Study: Clinical Results: Innocuité et efficacité du traitement de l'écosystème microbien (met–2) dans la dépression majeure – une étude de phase 2 à double insu contrölée par placebo : résultats cliniques
The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression – A Phase 2, Double-Blind, Placebo-Controlled Study: Clinical Results: Innocuité et efficacité du traitement de l'écosystème microbien (met–2) dans la dépression majeure – une étude de phase 2 à double insu contrölée par placebo : résultats cliniques Open
Objectives: This study examines the safety and efficacy of a fecal transplant alternative, Microbial Ecosystem Therapeutic-2 (MET-2), in improving symptoms of depression. The primary objective of this study is to assess changes in depressi…
View article: Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes périnatals
Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes périnatals Open
Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) publishes clinical practice guidelines for mood and anxiety disorders. This CANMAT guideline aims to provide comprehensive clinical guidance for the pregnancy and pos…
View article: Multi-voxel pattern analysis for characterizing functional connectivity and neurocognitive function in major depression: A CAN-BIND-1 report
Multi-voxel pattern analysis for characterizing functional connectivity and neurocognitive function in major depression: A CAN-BIND-1 report Open
View article: Lam Employment Absence and Productivity Scale (LEAPS): Analysis of the minimal clinically important difference (MCID) in patients with major depressive disorder using data from the CAN-BIND-1 study
Lam Employment Absence and Productivity Scale (LEAPS): Analysis of the minimal clinically important difference (MCID) in patients with major depressive disorder using data from the CAN-BIND-1 study Open
OBJECTIVES: Major depressive disorder (MDD) is associated with significant impairment in occupational functioning. The Lam Employment Absence and Productivity Scale (LEAPS) is a self-report questionnaire validated for the assessment of wor…
View article: Correction: Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1
Correction: Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1 Open
[This corrects the article DOI: 10.1371/journal.pone.0253023.].
View article: Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study
Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study Open
View article: Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume
Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume Open
View article: Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy
Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy Open
Clinical studies of major depression (MD) generally focus on group effects, yet interindividual differences in brain function are increasingly recognized as important and may even impact effect sizes related to group effects. Here, we exam…
View article: PRECISE trial (Pain RElief Combination Intervention StratEgies): protocol for the clinical trial of a pregabalin–melatonin combination for fibromyalgia
PRECISE trial (Pain RElief Combination Intervention StratEgies): protocol for the clinical trial of a pregabalin–melatonin combination for fibromyalgia Open
Introduction Fibromyalgia is associated with chronic widespread pain and disturbed sleep. Multidisciplinary, multimodal management often includes pharmacotherapy; however, current drugs used to treat fibromyalgia provide meaningful benefit…
View article: International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)
International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic) Open
View article: Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes Open
Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate …
View article: Stressful Life Events and Reward Processing in Adults: Moderation by Depression and Anhedonia
Stressful Life Events and Reward Processing in Adults: Moderation by Depression and Anhedonia Open
Background. Exposure to acute stress is associated with reduced reward processing in laboratory studies in animals and humans. However, less clear is the association between reward processing and exposure to naturalistic stressful life eve…
View article: Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study)
Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study) Open
Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Seco…
View article: Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review
Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review Open
These preliminary results, suggesting decreases in pain following iTBS treatment, provide a rationale for future rigorous investigations to evaluate this intervention for depression and comorbid chronic pain.
View article: Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study
Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study Open
Neural network-level changes underlying symptom remission in major depressive disorder (MDD) are often studied from a single perspective. Multimodal approaches to assess neuropsychiatric disorders are evolving, as they offer richer informa…
View article: Harnessing the potential of community-based participatory research approaches in bipolar disorder
Harnessing the potential of community-based participatory research approaches in bipolar disorder Open
The quantity and sophistication of research on bipolar disorder (BD) has expanded rapidly in the past decade. Despite progress, the field faces challenges in improving individuals' quality of life (QoL) and symptom outcomes, adapting treat…
View article: Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder
Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder Open
Background Identifying neuroimaging biomarkers of antidepressant response may help guide treatment decisions and advance precision medicine. Aims To examine the relationship between anhedonia and functional neurocircuitry in key reward pro…
View article: Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy
Large Individual Differences in Functional Connectivity in the Context of Major Depression and Antidepressant Pharmacotherapy Open
Clinical studies of major depression (MD) often examine differences between groups whilst ignoring within-group variation. However, inter-individual differences in brain function are increasingly recognised as important and may impact effe…
View article: Influence of <i>CYP2C19</i>, <i>CYP2D6</i>, and <i>ABCB1</i> Gene Variants and Serum Levels of Escitalopram and Aripiprazole on Treatment-Emergent Sexual Dysfunction: A Canadian Biomarker Integration Network in Depression 1 (CAN-BIND 1) Study
Influence of <i>CYP2C19</i>, <i>CYP2D6</i>, and <i>ABCB1</i> Gene Variants and Serum Levels of Escitalopram and Aripiprazole on Treatment-Emergent Sexual Dysfunction: A Canadian Biomarker Integration Network in Depression 1 (CAN-BIND 1) Study Open
Objectives Treatment-emergent sexual dysfunction is frequently reported by individuals with major depressive disorder (MDD) on antidepressants, which negatively impacts treatment adherence and efficacy. We investigated the association of p…
View article: Developing an Electroencephalography-Based Model for Predicting Response to Antidepressant Medication
Developing an Electroencephalography-Based Model for Predicting Response to Antidepressant Medication Open
Importance Untreated depression is a growing public health concern, with patients often facing a prolonged trial-and-error process in search of effective treatment. Developing a predictive model for treatment response in clinical practice …