Explanipedia

PROTON THERAPY FOR GRADE 3 SPINAL MENINGIOMA- A CASE REPORT Open

Rovel Colaco, Gillian Whitfield, Jasima Latif, S. Sharma · 2025

CASE REPORT: RARE CASE OF RETROORBITAL CHOROID MENINGIOMA TREATED WITH PROTON THERAPY Open

S. Sharma, Rovel Colaco, Shermaine Pan · 2025

CENTRAL NEUROCYTOMA TREATED WITH PROTON BEAM THERAPY: A SINGLE INSTITUTION EXPERIENCE Open

Jasima Latif, Shermaine Pan, Rovel Colaco · 2025

CTNI-20. NEOADJUVANT RADIOTHERAPY IN GLIOBLASTOMA IDH-WILDTYPE: INTERIM RESULTS FROM THE POBIG (PREOPERATIVE BRAIN IRRADIATION IN GLIOBLASTOMA) STUDY Open

Gerben R. Borst, Federico Roncaroli, Matthew Bailey, Rovel Colaco, R. Cooper , et al. · 2025

Glioblastoma IDH-wildtype is a highly infiltrative and aggressive brain tumour, making complete surgical resection unachievable. Preclinical evidence suggests that surgical manipulation may contribute to tumour recurrence by stimulating th…

DEVELOPING A NURSE LED CLINIC TO DELIVER VORASIDINIB – PRACTICALITIES, PATIENTS AND OUTCOMES Open

Lisa Withington, Jennifer Bristow, Jocelyn Puzylo, Karan Patel, Rovel Colaco , et al. · 2025

AIMS The aim to establish a nurse-led service to facilitate patient access to Vorasidenib via the Managed Access Pro- gramme (MAP) independent of consultants’ clinic capacity; to deﬁne and pilot clinical management protocols; to quantify a…

IMPLEMENTING ROUTINE ELECTRONIC PATIENT-REPORTED OUTCOME MEASURES (EPROMS) FOR PATIENTS WITH PRIMARY TUMOURS OF THE CENTRAL NERVOUS SYSTEM Open

Julie Emerson, Thitikorn Nuamek, Lindsay Sudell, James Bristow, Gerben R. Borst , et al. · 2025

AIMS Electronic patient-reported outcome measures (ePROMs) are online questionnaires designed to collect patients’ self-reported information about their health. While the beneﬁts of ePROMs in patient care are well-documented, their integra…

Quality of Life Outcomes in Vestibular Schwannoma: A Prospective Analysis of Treatment Modalities Open

A Hotchkies, Elliot Heward, Andrea Wadeson, Calvin Heal, Simon Freeman , et al. · 2025

Objective Management options for vestibular schwannoma include microsurgery (MS), stereotactic radiosurgery (SRS), and watch, wait, and rescan (WWR). This study aimed to evaluate changes in patient and disease‐specific quality of life (QoL…

APPROACH: Analysis of Proton versus Photon Radiotherapy in Oligodendroglioma and Assessment of Cognitive Health – study protocol paper for a phase III multicentre, open-label randomised controlled trial Open

Finbar Slevin, Eleanor Hudson, Florien Boele, J.R. Powell, Samantha Noutch , et al. · 2025

Introduction Oligodendroglioma (ODG) is a rare type of brain tumour, typically diagnosed in younger adults and associated with prolonged survival following treatment. The current standard of care is maximal safe debulking surgery, radiothe…

Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study Open

Laurence Glancz, Cathal John Hannan, Alexandros Vyziotis, Gillian Potter, Rekha Siripurapu , et al. · 2024

Objective Skull base chordoma and chondrosarcoma are distinct sarcomas of the skull base but share significant therapeutic challenges due to their proximity to critical neurovascular structures, making surgical resection difficult. We soug…

GCT-13. OUTCOMES OF INTRACRANIAL GERMINOMA TREATED AT A SINGLE UK PROTON CENTRE ACCORDING TO UK CHILDREN’S CANCER AND LEUKAEMIA GROUP (CCLG) GUIDELINES Open

Love Goyal, Anna France, Simona Gaito, Rovel Colaco, Shermaine Pan , et al. · 2024

BACKGROUND After SIOP-CNS-GCT II closed in 2018, the CCLG recommended, with caveats, following the standard trial arms: 4 cycles of chemotherapy (Etoposide-Carboplatin alternating with Etoposide-Ifosfamide) followed by whole ventricular ra…

GCT-12. OUTCOMES OF INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMOURS (NGGCT) TREATED AT A SINGLE UK PROTON CENTRE ACCORDING TO UK CHILDREN’S CANCER AND LEUKAEMIA GROUP (CCLG) GUIDANCE, INCLUDING EARLY IMPROVED OUTCOMES USING WHOLE VENTRICULAR RADIOTHERAPY (WVRT) FOR LOCALISED DISEASE Open

Love Goyal, Anna France, Simona Gaito, Rovel Colaco, Shermaine Pan , et al. · 2024

BACKGROUND After SIOP-CNS-GCT-II closed in 2018, the CCLG recommended, with caveats, following standard trial arms: 4 Cisplatin-Etoposide-Ifosfamide (PEI) cycles, then focal radiotherapy (FRT) (54Gy/30fractions) to primary site(s) for loca…

PERCEIVED BARRIERS TO EXPANDING ACCESS TO HIGH-QUALITY CARE FOR SKULL BASE CHORDOMA: SURVEY RESPONSES FROM THE PTCOG SKULL BASE SUBCOMMITTEE Open

Rovel Colaco, Marianne Aznar, Warissara Rongthong, Hamid Mammar, Akmal Safwat , et al. · 2024

VARIATION IN TUMOR AND CLINICAL TARGET VOLUME CONTOURS FOR SKULL BASE CHORDOMA: BASELINE DATA FROM THE PTCOG SKULL BASE SUBCOMMITTEE Open

Mark W. McDonald, Jun Zhou, Adam L. Holtzman, Anita Mahajan, Alberto Iannalfi , et al. · 2024

CHILDHOOD CANCER SURVIVORS WITH RADIATION-INDUCED MENINGIOMA: IS REIRRADIATION WITH PROTON BEAM THERAPY A GOOD OPTION? Open

Jeremy Khong, Shermaine Pan, Rovel Colaco, Gillian Whitfield · 2024

Radiotherapy intensification for atypical and malignant meningiomas: A systematic review Open

Simona Gaito, Love Goyal, Romélie Rieu, Anna France, N.G. Burnet , et al. · 2023

Background The outcomes of nonbenign (WHO Grades 2 and 3 [G2, G3]) meningiomas are suboptimal and radiotherapy (RT) dose intensification strategies have been investigated. The purpose of this review is to report on clinical practice and ou…

PREOPERATIVE BRAIN IRRADIATION IN GLIOBLASTOMA (POBIG TRIAL): FEASIBILITY AND EVALUATION OF TREATMENT RESPONSE IN ENHANCING AND NON-ENHANCING REGIONS Open

Mueez Waqar, Federico Roncaroli, Ibrahim Djoukhadar, Lisa Withington, Christopher Golby , et al. · 2023

AIMS Patients with glioblastoma have dismal outcomes and there is an urgent need for new treatment modalities. The POBIG trial is the first to evaluate the safety and feasibility of single-fraction preoperative radiotherapy for newly diagn…

RCR Meetings Open

Rovel Colaco, Jon Smith, Paul McCoubrie, Dominic Fay, Ganesh Radhakrishna · 2023

P18.07.A CLINICAL OUTCOMES OF PATIENTS TREATED WITH FRACTIONATED PHOTON RADIOTHERAPY FOR INTERMEDIATE AND HIGH-RISK MENINGIOMAS AT THE CHRISTIE HOSPITAL Open

Lipika Goyal, Simona Gaito, A France, Rovel Colaco, Catherine McBain , et al. · 2023

BACKGROUND Radiotherapy is often used as a postoperative treatment for WHO Grade 2 (G2) and Grade 3 (G3) meningioma. However, there is limited data on the long-term outcomes following radiotherapy for these patients. The present study aims…

RCR meetings Open

Rovel Colaco, Jon Smith, Paul McCoubrie, Dominic Fay, Ganesh Radhakrishna · 2023

Proton Beam Therapy in the Reirradiation Setting of Brain and Base of Skull Tumour Recurrences Open

Simona Gaito, N.G. Burnet, Marianne Aznar, Giulia Marvaso, Barbara Alicja Jereczek‐Fossa , et al. · 2023

Proton Beam Therapy in the Oligometastatic/Oligorecurrent Setting: Is There a Role? A Literature Review Open

Simona Gaito, Giulia Marvaso, Ramón Ortiz, A. Crellin, Marianne Aznar , et al. · 2023

Background: Stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS) with conventional photon radiotherapy (XRT) are well-established treatment options for selected patients with oligometastatic/oligorecurrent disease.…

Study protocol: PreOperative Brain Irradiation in Glioblastoma (POBIG) – A phase I trial Open

Mueez Waqar, Federico Roncaroli, Ibrahim Djoukhadar, Leila Akkari, Claire O’Leary , et al. · 2023

NCT03582514 (clinicaltrials.gov).

Surgery versus radiosurgery for vestibular schwannoma: Shared decision making in a multidisciplinary clinic Open

Francesca Colombo, Helen Maye, Scott Rutherford, Andrew T. King, Charlotte Hammerbeck-Ward , et al. · 2023

Background Our neurosurgical unit adopted a model of shared decision-making (SDM) based on multidisciplinary clinics for vestibular schwannoma (VS). A unique feature of this clinic is the interdisciplinary counseling process with a surgeon…

QLTI-07. IDENTIFYING RISK FACTORS FOR PROLONGED TRANSFUSION-DEPENDENT TEMOZOLOMIDE-INDUCED THROMBOCYTOPAENIA IN PATIENTS RECEIVING CONCURRENT CHEMO-RADIOTHERAPY FOR GLIOBLASTOMA (GBM) Open

Nashwah Ismail, Karan A. Patel, Tapan Parikh, Rovel Colaco, Catherine McBain · 2022

BACKGROUND Temozolomide-induced thrombocytopaenia is a well-recognised clinical issue with significant inter-patient variation. However, knowledge of the extent of the problem and its potential risk factors remains limited. Our aim was to …

Prolonged Transfusion-Dependent Temozolomide-Induced Thrombocytopaenia in Glioblastoma: Risk Factors Remain Elusive Open

Nashwah Ismail, Karan Patel, Rovel Colaco, Gerben R. Borst, D. Milanović , et al. · 2022

AIMS Temozolomide-induced thrombocytopaenia is well-recognised; clinical-course varies widely. Aims: To identify risk factors for prolonged thrombocytopaenia; improve patient-care; inform trial design. METHOD Glioblastoma (GBM) patients re…

Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy Open

N.G. Burnet, T. Mee, Simona Gaito, N.F. Kirkby, Adam Aitkenhead , et al. · 2022

Objectives: High-energy Proton Beam Therapy (PBT) commenced in England in 2018 and NHS England commissions PBT for 1.5% of patients receiving radical radiotherapy. We sought expert opinion on the level of provision. Methods: Invitations we…

P2.08-02 Outcomes Following Stereotactic Radiosurgery for Syncronous Brain Metastases in Non-Small Cell Lung Cancer Open

Fiona Wilson, Sura O. Yousif, Yezhou Li, N. Bayman, Clara C. Chan , et al. · 2019

EP-1982: How does time affect radiosurgery treatment planning? Open

João Marcelo Fonseca, Rovel Colaco, E. Netto, Miguel Ángel García Fernández, R. Pocinho , et al. · 2018

Radiation Necrosis – A Growing Problem in a Case of Brain Metastases Following Whole Brain Radiotherapy and Stereotactic Radiosurgery Open

Yee Pei Song, Rovel Colaco · 2018

Stereotactic radiosurgery (SRS) provides excellent control in the treatment of brain metastases (BM). The use of newer, targeted and immunotherapy treatments have resulted in improved overall survival in patients even with an extensive met…

Improving survivorship in brain metastases patents: assessing and addressing educational needs in non-neuro-oncology health professionals Open

Sara Robson, Elizabeth Molloy, Charlotte Smith, Julie Emerson, Gillian Whitfield , et al. · 2018

BACKGROUND: Outcomes of patients treated for brain metastases are improving, with growing numbers of long-term survivors following surgery and stereotactic radiosurgery (SRS). Many patients continue predominantly under the care of their si…

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