Rowan C. Walters
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View article: Bioenergetic metabolism restarts alongside germinant sensing and hydration in bacterial spore germination
Bioenergetic metabolism restarts alongside germinant sensing and hydration in bacterial spore germination Open
Bacterial spore germination transforms spores from dormant bodies to vegetative cells. Initiation of germination or spore rehydration can proceed without exogenous energy sources, so bioenergetic processes in germination have been overlook…
View article: Remission spectroscopy resolves the mode of action of bedaquiline within living mycobacteria
Remission spectroscopy resolves the mode of action of bedaquiline within living mycobacteria Open
Bedaquiline, an ATP synthase inhibitor, is the spearhead of transformative therapies against drug-resistant Mycobacterium tuberculosis . Here, remission spectroscopy is used to measures the energy-transducing cytochromes within unperturbed…
View article: Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma
Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma Open
View article: Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade
Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade Open
Summary The mitochondrial genome encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutation in the cancer genome, with truncating mutations in respiratory co…