Rowan Callahan
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View article: Cell free RNA detection of pancreatic cancer in pre diagnostic high risk and symptomatic patients
Cell free RNA detection of pancreatic cancer in pre diagnostic high risk and symptomatic patients Open
View article: RUNX1::ETO translocations must precede CSF3R mutations to promote acute myeloid leukemia development
RUNX1::ETO translocations must precede CSF3R mutations to promote acute myeloid leukemia development Open
View article: Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors
Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors Open
View article: Correction to: Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia
Correction to: Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia Open
View article: Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies
Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies Open
View article: Geographic differences in gut microbiota composition impact susceptibility to enteric infection
Geographic differences in gut microbiota composition impact susceptibility to enteric infection Open
Large-scale studies of human gut microbiomes have revealed broad differences in composition across geographically distinct populations. Yet, studies examining impacts of microbiome composition on various health outcomes typically focus on …
View article: Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia
Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia Open
View article: Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia
Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia Open
Mutations in SET binding protein 1 (SETBP1) are associated with poor outcomes in myeloid leukemias. In the Ras-driven leukemia, juvenile myelomonocytic leukemia, SETBP1 mutations are enriched in relapsed disease. While some mechanisms for …
View article: ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II
ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II Open
Mutations in the gene Additional Sex-Combs Like 1 (ASXL1) are recurrent in myeloid malignancies as well as the pre-malignant condition clonal hematopoiesis, where they are universally associated with poor prognosis. An epigenetic regulator…
View article: Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia
Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia Open
Acute myeloid leukemia (AML) is a deadly hematologic malignancy with poor prognosis, particularly in the elderly. Even among individuals with favorable-risk disease, approximately half will relapse with conventional therapy. In this clinic…
View article: Disruption of the Gut Microbiome Increases the Risk of Periprosthetic Joint Infection in Mice
Disruption of the Gut Microbiome Increases the Risk of Periprosthetic Joint Infection in Mice Open
Background Periprosthetic joint infection (PJI) is one of the most devastating complications of total joint arthroplasty. Given the mortality and morbidity associated with PJI and the challenges in treating it, there has been increased int…
View article: The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis
The effects of metabolic syndrome, obesity, and the gut microbiome on load-induced osteoarthritis Open