Roxana Coras
YOU?
Author Swipe
View article: Targeted Microbial Shifts and Metabolite Profiles Were Associated with Clinical Response to an Anti-Inflammatory Diet in Osteoarthritis
Targeted Microbial Shifts and Metabolite Profiles Were Associated with Clinical Response to an Anti-Inflammatory Diet in Osteoarthritis Open
Introduction: Osteoarthritis (OA) is a chronic degenerative joint disease with limited treatment options focused primarily on symptom management. Emerging evidence suggests that dietary interventions may influence inflammation and pain thr…
View article: Oxylipin serum profile changes in response to an open-label anti-inflammatory dietary intervention
Oxylipin serum profile changes in response to an open-label anti-inflammatory dietary intervention Open
NCT04999683.
View article: Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression Open
Exposure to particles is a driver of several inflammatory diseases. Here, we investigated macrophage responses to monosodium urate crystals, calcium pyrophosphate crystals, aluminum salts, and silica nanoparticles. While each particle indu…
View article: Young-GRAPPA 2023: The Future Is Bright
Young-GRAPPA 2023: The Future Is Bright Open
Two years after its inception, Young Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (Y-GRAPPA) has established itself as a productive network for junior investigators and clinicians. The group’s achievements in the …
View article: Synovial 5‐Lipoxygenase–Derived Oxylipins Define a Lympho‐Myeloid–Enriched Synovium
Synovial 5‐Lipoxygenase–Derived Oxylipins Define a Lympho‐Myeloid–Enriched Synovium Open
Objective Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation and may remain overexpressed in refractory synovitis. In plasma, they could also be biomarkers of synovial pathology. The …
View article: Young-GRAPPA (Y-GRAPPA) at the 2022 GRAPPA Annual Meeting: One Year in Y-GRAPPA. Where Do We Stand, Where Do We Go?
Young-GRAPPA (Y-GRAPPA) at the 2022 GRAPPA Annual Meeting: One Year in Y-GRAPPA. Where Do We Stand, Where Do We Go? Open
Young-GRAPPA (Y-GRAPPA) was introduced at the 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting. Here we present the 1-year progress of Y-GRAPPA and future plans of this enthusiastic group …
View article: Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis
Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis Open
Oxylipins derived from n-3 fatty acids are suggested as the link between these fatty acids and reduced inflammation. The aim of the present study was to explore the effect of a randomized controlled cross-over intervention on oxylipin patt…
View article: Baseline microbiome and metabolome are associated with response to ITIS diet in an exploratory trial in patients with rheumatoid arthritis
Baseline microbiome and metabolome are associated with response to ITIS diet in an exploratory trial in patients with rheumatoid arthritis Open
Changes in diet might modify the faecal microbiome and metabolomic profile, affecting pain in rheumatoid arthritis (RA). We examined the effect of an anti-inflammatory “ITIS” diet1 on clinical outcomes, gut microbiome, and metabolome in RA…
View article: Lipidomic Profiling in Synovial Tissue
Lipidomic Profiling in Synovial Tissue Open
The analysis of synovial tissue offers the potential for the comprehensive characterization of cell types involved in arthritis pathogenesis. The studies performed to date in synovial tissue have made it possible to define synovial pathoty…
View article: Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response
Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response Open
Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MS…
View article: Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast‐like Synoviocytes
Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast‐like Synoviocytes Open
Objective Since previous studies indicate that metabolism is altered in rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLS), we undertook this study to determine if changes in the genome‐wide chromatin and DNA states in genes asso…
View article: Additional file 2 of Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes
Additional file 2 of Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes Open
Additional file 2: Supplementary Table 1. Included the 1105 compounds of known identity from the Metabolon platform. Supplementary Table 2. Relative levels of fatty acids identified in the UCSD cohort. Supplementary Table 3. Fatty acids id…
View article: Differences in oxylipin profile in psoriasis versus psoriatic arthritis
Differences in oxylipin profile in psoriasis versus psoriatic arthritis Open
Background Oxylipins are biological lipids that have been implicated in inflammation. We previously found that certain oxylipins correlated with clinical manifestations in psoriatic arthritis (PsA) patients. Here, we compare oxylipin profi…
View article: Reference data-set driven metabolomics
Reference data-set driven metabolomics Open
Human untargeted metabolomics studies succeed in annotating only ~10% of molecular features. We, therefore, introduce reference data-driven analysis that uses the source data as a pseudo-MS/MS reference library to match against human metab…
View article: Monosodium Urate Crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response
Monosodium Urate Crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response Open
How macrophages are programmed to respond to monosodium urate crystals (MSUc) is incompletely understood partly due to the use of a toll-like receptor-induced priming step. Here, using genome wide transcriptomic analysis and biochemical as…
View article: Additional file 2 of Differences in oxylipin profile in psoriasis versus psoriatic arthritis
Additional file 2 of Differences in oxylipin profile in psoriasis versus psoriatic arthritis Open
Additional file 2: Supplementary Table 1. Characteristics of PsO patients with low (PASI ≤ 2.5) and high (PASI > 2.5) skin disease activity. Supplementary Table 2. Comparison of oxylipins between PsO patients with low (PASI ≤ 2.5) and high…
View article: Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis
Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis Open
Objective Eicosanoids modulate inflammation via complex networks involving different pathways and downstream mediators, including oxylipins. Although altered eicosanoids are linked to rheumatoid arthritis (RA), suggesting that metabolizati…
View article: Analysis of the correlation between disease activity score 28 and its ultrasonographic equivalent in rheumatoid arthritis patients
Analysis of the correlation between disease activity score 28 and its ultrasonographic equivalent in rheumatoid arthritis patients Open
Objective: To study the differences between disease activity score 28 (DAS28) index and an ultrasound (US) approach using index echographic disease activity score (ECODAS). Methods: This was a cross-sectional study in patients diagnosed wi…