Roxana E. Iacob
YOU?
Author Swipe
View article: Structural mechanism of a drug-binding process involving a large conformational change of the protein target
Structural mechanism of a drug-binding process involving a large conformational change of the protein target Open
Proteins often undergo large conformational changes when binding small molecules, but atomic-level descriptions of such events have been elusive. Here, we report unguided molecular dynamics simulations of Abl kinase binding to the cancer d…
View article: Supplementary Figures S1-S18 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Figures S1-S18 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Supplementary Figures S1-S18
View article: Supplementary Table S1 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S1 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Data collection and refinement statistics
View article: Supplementary Tables S2-S10 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Tables S2-S10 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Proteomics data from mouse tissues.
View article: Supplementary Table S12 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S12 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
GSEA analysis of pancreata expressing WT or mutant K-Ras.
View article: Supplementary Tables S14-S17 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Tables S14-S17 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Proteomics data from human cell lines.
View article: Supplementary Table S11 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S11 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
GSEA analysis of colons expressing WT or mutant K-Ras.
View article: Data from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Data from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS protei…
View article: Data from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Data from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS protei…
View article: Supplementary Table S11 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S11 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
GSEA analysis of colons expressing WT or mutant K-Ras.
View article: Supplementary Figures S1-S18 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Figures S1-S18 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Supplementary Figures S1-S18
View article: Supplementary Tables S2-S10 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Tables S2-S10 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Proteomics data from mouse tissues.
View article: Supplementary Tables S14-S17 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Tables S14-S17 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Proteomics data from human cell lines.
View article: Supplementary Table S12 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S12 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
GSEA analysis of pancreata expressing WT or mutant K-Ras.
View article: Supplementary Table S1 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S1 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
Data collection and refinement statistics
View article: Supplementary Table S13 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S13 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
GSEA analysis of spleens expressing WT or mutant K-Ras.
View article: Supplementary Table S13 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup>
Supplementary Table S13 from Tissue-Specific Oncogenic Activity of KRAS<sup>A146T</sup> Open
GSEA analysis of spleens expressing WT or mutant K-Ras.
View article: Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change Open
Integrin α5β1 mediates cell adhesion to the extracellular matrix by binding fibronectin (Fn). Selectivity for Fn by α5β1 is achieved through recognition of an RGD motif in the 10th type III Fn domain (Fn10) and the synergy site in the nint…
View article: Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker Open
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor (VWF) to GPIbα on platelets to form a platelet plug. A1 is activated by tensile force on VWF concatemers imparted…
View article: Author response: Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker
Author response: Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Hemostasis in the arte…
View article: Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker
Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker Open
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor to GPIbα on platelets to form a platelet plug. A1 is activated by tensile force on VWF concatemers imparted by hy…
View article: Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family
Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family Open
The 33 members of the transforming growth factor beta (TGF-β) family are fundamentally important for organismal development and homeostasis. Family members are synthesized and secreted as pro-complexes of prodomains that are non-covalently…
View article: Functional and Structural Characterization of Factor Xa Dimer in Solution
Functional and Structural Characterization of Factor Xa Dimer in Solution Open
Previous studies showed that binding of water-soluble phosphatidylserine (C6PS) to bovine factor Xa (FXa) leads to Ca2+-dependent dimerization in solution. We report the effects of Ca2+, C6PS, and dimerization on the activity and structure…
View article: Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism Open
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific protein substrates in order to alter their degradation rate and sub-cellular localization. USP7 has been proposed as a thera…
View article: General structural features that regulate integrin affinity revealed by atypical αVβ8
General structural features that regulate integrin affinity revealed by atypical αVβ8 Open
Integrin αVβ8, which like αVβ6 functions to activate TGF-βs, is atypical. Its β8 subunit binds to a distinctive cytoskeleton adaptor and does not exhibit large changes in conformation upon binding to ligand. Here, crystal structures, hydro…
View article: Tissue-Specific Oncogenic Activity of KRASA146T
Tissue-Specific Oncogenic Activity of KRASA146T Open
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS protei…
View article: Tissue-Specific Oncogenic Activity of KRASA146T
Tissue-Specific Oncogenic Activity of KRASA146T Open
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS protei…