Roxana Ghiulai
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View article: The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles
The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles Open
One of several promising strategies for increasing the bioavailability and therapeutic potential of high-lipophilic biologically active compounds is gold nanoparticle formulation. The current study describes the synthesis and biological an…
View article: Novel Semisynthetic Betulinic Acid−Triazole Hybrids with In Vitro Antiproliferative Potential
Novel Semisynthetic Betulinic Acid−Triazole Hybrids with In Vitro Antiproliferative Potential Open
Betulinic acid, BA, is a lupane derivative that has caught the interest of researchers due to the wide variety of pharmacological properties it exhibits towards tumor cells. Because of their prospective increased anti−proliferative efficac…
View article: The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential
The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential Open
Cancer, in all its types and manifestations, remains one of the most frequent causes of death worldwide; an important number of anticancer drugs have been developed from plants, fungi and animals, starting with natural compounds that were …
View article: The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach
The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach Open
Implementing metallic nanoparticles as research instruments for the transport of therapeutically active compounds remains a fundamentally vital work direction that can still potentially generate novelties in the field of drug formulation d…
View article: Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry
Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry Open
Betulinic acid (BA) has been extensively studied in recent years mainly for its antiproliferative and antitumor effect in various types of cancers. Limited data are available regarding the pharmacokinetic profile of BA, particularly its me…
View article: Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential
Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential Open
Medicinal plants have been used by humans since ancient times for the treatment of various diseases and currently represent the main source of a variety of phytocompounds, such as triterpenes. Pentacyclic triterpenes have been subjected to…
View article: Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents
Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents Open
Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient and selective anticancer agents whose underlying mechanisms of action have been widely investigated. The introduction of N-bearing heterocycles (e.g., t…
View article: Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II) Open
Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable therapeutic properties such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, antidiabetic, neuroprotective, lipolytic…
View article: Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) Open
Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject of numerous in vitro and in vivo studies. However, their underlying mechanisms of action in various pathologies are not comple…
View article: Phytochemical Profile, Antioxidant and Wound Healing Potential of Three Artemisia Species: In Vitro and In Ovo Evaluation
Phytochemical Profile, Antioxidant and Wound Healing Potential of Three Artemisia Species: In Vitro and In Ovo Evaluation Open
Skin injuries, and especially wounds of chronic nature, can cause a major negative impact on the quality of life. New efficient alternatives are needed for wound healing therapy and herbal products are being investigated due to a high cont…
View article: The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges
The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges Open
The last decade has witnessed a sustained increase in the research development of modern-day chemo-therapeutics, especially for those used for high mortality rate pathologies. However, the therapeutic landscape is continuously changing as …
View article: The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents
The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents Open
Triterpenic compounds stand as a widely investigated class of natural compounds due to their remarkable therapeutic potential. However, their use is currently being hampered by their low solubility and, subsequently, bioavailability. In or…
View article: Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters
Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters Open
Melissa officinalis (MO) is a medicinal plant well-known for its multiple pharmacological effects, including anti-inflammatory, anticancer and beneficial effects on skin recovery. In this context, the present study was aimed to investigate…
View article: Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds
Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds Open
Pentacyclic triterpenes represent an important class of intensively studied substances in the past two decades due to their wide spectrum of pharmacological effects. Even though this class is being thoroughly researched for the development…
View article: Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents
Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents Open
Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to…
View article: Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir
Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir Open
The Herpes simplex viruses (HSV-1, HSV-2) are responsible for a wide variety of conditions, from cutaneous-mucosal to central nervous system (CNS) infections and occasional infections of the visceral organs, some of them with a lethal end.…
View article: Nutritional, Antioxidant, Antimicrobial, and Toxicological Profile of Two Innovative Types of Vegan, Sugar-Free Chocolate
Nutritional, Antioxidant, Antimicrobial, and Toxicological Profile of Two Innovative Types of Vegan, Sugar-Free Chocolate Open
Increased sugar consumption and unhealthy dietary patterns are key drivers of many preventable diseases that result in disability and death worldwide. However, health awareness has increased over the past decades creating a massive on-goin…
View article: Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches Open
Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, prol…
View article: Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity
Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity Open
Albendazole is a benzimidazole derivative with documented antitumor activity and low toxicity to healthy cells. The major disadvantage in terms of clinical use is its low aqueous solubility which limits its bioavailability. Albendazole was…
View article: <p>Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions</p>
Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions Open
Collectively, these findings indicate that BA-loaded magnetoliposomes, under hyperthermal conditions, might serve as a promising strategy for breast adenocarcinoma treatment.
View article: Hydro-alcoholic Extracts of Roots and Sprouts of Armoracia rusticana: Assessment of Antioxidant and Cytotoxic Activity
Hydro-alcoholic Extracts of Roots and Sprouts of Armoracia rusticana: Assessment of Antioxidant and Cytotoxic Activity Open
Armoracia rusticana � horseradish is a well-known vegetable used from ancient times and consumed nowadays more for its taste than its pharmacological properties, even though it proved to be a good agent in fighting several health problems.…
View article: A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media
A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media Open
Polyurethane nano- and micro-structures have been studied intensively in the last decade as drug delivery systems for various herbal extracts as well as pure active biological substances. Their biocompatibility, haemocompatibility, safe de…
View article: Lemon Balm Extracts Prevent Breast Cancer Progression <i>In Vitro</i> and <i>In Ovo</i> on Chorioallantoic Membrane Assay
Lemon Balm Extracts Prevent Breast Cancer Progression <i>In Vitro</i> and <i>In Ovo</i> on Chorioallantoic Membrane Assay Open
Breast cancer is the most frequently diagnosed malignant pathology, representing the primary cause of cancer death in women. Natural products are an appealing strategy to limit the progression of the disease. Targeting angiogenesis in brea…
View article: <p>Evaluation of essential oil obtained from <em>Mentha×piperita</em> L. against multidrug-resistant strains</p>
Evaluation of essential oil obtained from <em>Mentha×piperita</em> L. against multidrug-resistant strains Open
The present study highlights the bactericidal activity of Mentha×piperita L. essential oil on all tested MDR or extensively drug-resistant Gram-positive and Gram-negative strains of Staphylococcus aureus, Escherichia coli, Klebsiellapneumo…
View article: Evaluation of essential oil obtained from Mentha×piperita L. against multidrug-resistant strains
Evaluation of essential oil obtained from Mentha×piperita L. against multidrug-resistant strains Open
Delia Muntean,1 Monica Licker,1 Ersilia Alexa,2 Iuliana Popescu,2 Calin Jianu,3 Valentina Buda,4 Cristina Adriana Dehelean,5 Roxana Ghiulai,6 Florin Horhat,1 Delia Horhat,7 Corina Danciu8 1Department of Microbiology, “Victor Babes” Univers…
View article: Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening
Romanian Wormwood (Artemisia absinthium L.): Physicochemical and Nutraceutical Screening Open
Artemisia species are used worldwide for their antioxidant, antimicrobial and anti-inflammatory properties. This research was designed to investigate the phytochemical profile of two ethanolic extracts obtained from leaves and stems of A. …
View article: Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity
Cocrystal Formation of Betulinic Acid and Ascorbic Acid: Synthesis, Physico-Chemical Assessment, Antioxidant, and Antiproliferative Activity Open
Betulinic acid (BA) was demonstrated to be a very promising anticancer agent against various tumor cell lines such as breast, colon, lung, and brain. Despite its strong cytotoxic effect, betulinic acid exhibits low water solubility, featur…