Roxana Merino-Martinez
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View article: Exposometer-based assessment of laboratory work environment
Exposometer-based assessment of laboratory work environment Open
Human health is impacted by a wide range of exposures, including biological, chemical, and physical factors, making it challenging to assess their combined environmental health effects comprehensively. Advances in wearable and stationary s…
View article: The Swedish Cervical Screening Cohort
The Swedish Cervical Screening Cohort Open
The Cervical Screening Cohort enrols women screened for human papillomavirus (HPV) and cervical abnormalities within the capital region of Sweden from the organised screening program and the non-organised testing of cervical samples. The c…
View article: Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer
Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer Open
View article: BIBBOX, a FAIR toolbox and App Store for life science research
BIBBOX, a FAIR toolbox and App Store for life science research Open
Data quality has recently become a critical topic for the research community. European guidelines recommend that scientific data should be made FAIR: findable, accessible, interoperable and reusable. However, as FAIR guidelines do not spec…
View article: Swedish Cervical Screening Samples 2011-2021
Swedish Cervical Screening Samples 2011-2021 Open
The Cervical Screening Cohort enrols women screened for human papillomavirus (HPV) and cervical abnormalities within the capital region of Sweden, both from the organised screening program and the non-organised testing of cervical samples.…
View article: Ontology and semantic metadata for metagenomic profiles and tools for NGS data management. Public deliverable 9.3
Ontology and semantic metadata for metagenomic profiles and tools for NGS data management. Public deliverable 9.3 Open
This deliverable describes how to manage metagenomics data in the HEAP technical platform. It provides the data model representing semantics to access metadata about metagenomics experiments. The model provides the necessary components to …
View article: HEAP Informatics Platform and Knowledge Engine. Public deliverable 6.1
HEAP Informatics Platform and Knowledge Engine. Public deliverable 6.1 Open
This document provides a full view of the capabilities of the Knowledge Engine within the Human Exposome Assessment Platform (HEAP). This document describes the data management, data warehousing, data sharing and integration with the Infor…
View article: Human exposome assessment platform
Human exposome assessment platform Open
The Human Exposome Assessment Platform (HEAP) is a research resource for the integrated and efficient management and analysis of human exposome data. The project will provide the complete workflow for obtaining exposome actionable knowledg…
View article: Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events
Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events Open
Introduction: The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology to facilitate data sharing in biobanks and sample collections. The MIABIS Cor…
View article: S871 CURATIVE STRATEGY (GEM-CESAR) FOR HIGH-RISK SMOLDERING MYELOMA: CARFILZOMIB, LENALIDOMIDE AND DEXAMETHASONE (KRD) AS INDUCTION FOLLOWED BY HDT-ASCT, CONSOLIDATION WITH KRD AND MAINTENANCE WITH RD
S871 CURATIVE STRATEGY (GEM-CESAR) FOR HIGH-RISK SMOLDERING MYELOMA: CARFILZOMIB, LENALIDOMIDE AND DEXAMETHASONE (KRD) AS INDUCTION FOLLOWED BY HDT-ASCT, CONSOLIDATION WITH KRD AND MAINTENANCE WITH RD Open
Background: The blood units, stored as packed red blood cells (PRBC), are supplied according to the first-in-first-out (FIFO) criterion. However, the actual quality of the PRBC provided for transfusion, namely their capacity to exert the e…
View article: S121 SINGLE-CELL CHARACTERIZATION OF THE MULTIPLE MYELOMA (MM) IMMUNE MICROENVIRONMENT IDENTIFIES CD27- T CELLS AS POTENTIAL SOURCE OF TUMOR-REACTIVE LYMPHOCYTES
S121 SINGLE-CELL CHARACTERIZATION OF THE MULTIPLE MYELOMA (MM) IMMUNE MICROENVIRONMENT IDENTIFIES CD27- T CELLS AS POTENTIAL SOURCE OF TUMOR-REACTIVE LYMPHOCYTES Open
Background: The broad use of immunomodulatory drugs (IMiDs) and the breakthrough of novel immunotherapies in MM urge the optimization of immune monitoring for tailored treatments based on better prediction of patients’ response. For instan…
View article: PF609 HEAVY&LIGHT CHAIN MONITORING IN HIGH RISK SMOLDERING MULTIPLE MYELOMA PATIENTS INCLUDED IN THE GEM‐CESAR TRIAL: COMPARISON WITH CONVENTIONAL AND MINIMAL RESIDUAL DISEASE IMWG RESPONSE ASSESSMENT
PF609 HEAVY&LIGHT CHAIN MONITORING IN HIGH RISK SMOLDERING MULTIPLE MYELOMA PATIENTS INCLUDED IN THE GEM‐CESAR TRIAL: COMPARISON WITH CONVENTIONAL AND MINIMAL RESIDUAL DISEASE IMWG RESPONSE ASSESSMENT Open
Background: The GEM‐CESAR trial is a potentially curative strategy for high‐risk smoldering multiple myeloma (HRsMM) patients (pts) in which the primary endpoint is the assessment of bone marrow minimal residual disease (MRD) negativity. H…
View article: PS1581 COMPLEMENT SYSTEM ANALYSES IN PATIENTS SUSPECTED TO HAVE ATYPICAL HEMOLYTIC UREMIC SYNDROME
PS1581 COMPLEMENT SYSTEM ANALYSES IN PATIENTS SUSPECTED TO HAVE ATYPICAL HEMOLYTIC UREMIC SYNDROME Open
Background: Thrombotic microangiopathy (TMA) is characterized by mechanical hemolytic anemia, thrombocytopenia and organ damage, with the presence of microvascular thrombi. TMA can arise from different pathological conditions; from ADAMTS1…
View article: Aplicaciones web progresivas impulsadas por el avance de los estándares web
Aplicaciones web progresivas impulsadas por el avance de los estándares web Open
La tecnología móvil ocupa un papel primordial en la vida de las personas hasta el punto por el cual en la actualidad el teléfono móvil combinado con internet es el principal medio por el cual se accede a la información. La mejora permanent…
View article: Standardisation in life-science research - Making the case for harmonization to improve communication and sharing of data amongst researchers
Standardisation in life-science research - Making the case for harmonization to improve communication and sharing of data amongst researchers Open
Modern, high-throughput methods for the analysis of genetic information, gene and metabolic products and their interactions offer new opportunities to gain comprehensive information on life processes. The data and knowledge generated open …
View article: Baobab Laboratory Information Management System: Development of an Open-Source Laboratory Information Management System for Biobanking
Baobab Laboratory Information Management System: Development of an Open-Source Laboratory Information Management System for Biobanking Open
A laboratory information management system (LIMS) is central to the informatics infrastructure that underlies biobanking activities. To date, a wide range of commercial and open-source LIMSs are available and the decision to opt for one LI…
View article: Analytical and clinical validation of a novel in-house deep-sequencing method for minimal residual disease monitoring in a phase II trial for multiple myeloma
Analytical and clinical validation of a novel in-house deep-sequencing method for minimal residual disease monitoring in a phase II trial for multiple myeloma Open
This study was supported by the Cooperative Research Thematic Network grant RD12/0036/0061 of the Red de Cancer (Cancer Network of Excellence RTICC); the Subdireccion General de Investigacion Sanitaria (Instituto de Salud Carlos III, Spain…
View article: Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer
Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer Open
Patient registries are an essential tool to increase current knowledge regarding rare diseases. Understanding these data is a vital step to improve patient treatments and to create the most adequate tools for personalized medicine. However…
View article: Legal and ethical governance of intercontinental biobanking : Some experiences from a H2020 project
Legal and ethical governance of intercontinental biobanking : Some experiences from a H2020 project Open
Biobanks exist today on every continental though they have evolved differently in different parts of the world. The African States have been involved in biobank research for a considerable time but for decades large volumes of data and sam…
View article: 16 CF newborn screening in Uruguay: improvements in IRT methodology
16 CF newborn screening in Uruguay: improvements in IRT methodology Open
View article: Toward Global Biobank Integration by Implementation of the Minimum Information About BIobank Data Sharing (MIABIS 2.0 Core)
Toward Global Biobank Integration by Implementation of the Minimum Information About BIobank Data Sharing (MIABIS 2.0 Core) Open
This FAIRsharing record describes: MIABIS Core 2.0 represents the minimum information required to initiate collaborations between biobanks and to enable the exchange of biological samples and data. The aim is to facilitate the reuse of bio…
View article: Biomedbridges: Demonstration Of Interoperability Between Different Types Of Pm Data
Biomedbridges: Demonstration Of Interoperability Between Different Types Of Pm Data Open
The purpose of D8.3 is to describe the prototype IT systems for storing, structuring as well as providing controlled access and annotation/fitering to the data pertinent for the personalised medicine (referred as the ”PM system” in subsequ…
View article: Biomedbridges: A Prototype Federated Query Interface For Information On Biosamples, And Linking Of Biosamples And Disease Terminology To Genome
Biomedbridges: A Prototype Federated Query Interface For Information On Biosamples, And Linking Of Biosamples And Disease Terminology To Genome Open
This deliverable finalizes the work on linking biological sample-related information across data infrastructures, data availability levels and information types. A federated system for sample discovery across biobanks is described, and we …
View article: Mapping between biobank data elements
Mapping between biobank data elements Open
<p>Translational bioinformatics is an emerging field that studies how to use biomolecular data and knowledge for advancing medical care. This necessitates closer collaboration of specialists in bioinformatics and clinical informatics…
View article: Definition of personalised data types within BioMedBridges
Definition of personalised data types within BioMedBridges Open
The purpose of deliverable 8.2 is to describe the data types pertinent for personalised medicine and the links between them. To do this, we first identified a concrete use case: acute myeloid leukemia and then identified the needs of the k…