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View article: Diagnostic implications and correlates of plasma ADA2 activity and ADA2 variants
Diagnostic implications and correlates of plasma ADA2 activity and ADA2 variants Open
Objectives Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characte…
View article: HLH-like Hypersensitivity Reaction Secondary to Prolonged Piperacillin/Tazobactam: A Case Series
HLH-like Hypersensitivity Reaction Secondary to Prolonged Piperacillin/Tazobactam: A Case Series Open
Background Prolonged (>10 days) use of intravenous (IV) piperacillin/tazobactam has been associated with a risk of developing hemophagocytic lymphohistiocytosis (HLH) syndrome. However, clinical and biological descriptions of this rare …
View article: Use of a 24-Hour Hotline vs Voicemail for Off-Hour Support During Oral Immunotherapy for Food Allergy
Use of a 24-Hour Hotline vs Voicemail for Off-Hour Support During Oral Immunotherapy for Food Allergy Open
View article: Predictors of support line utilization by patients undergoing oral immunotherapy
Predictors of support line utilization by patients undergoing oral immunotherapy Open
View article: Effect‐modifying impact of age on sex‐based differences during oral immunotherapy
Effect‐modifying impact of age on sex‐based differences during oral immunotherapy Open
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View article: Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome Open
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by combined immunodeficiency, eczema, microthrombocytopenia, autoimmunity, and lymphoid malignancies. Gene therapy (GT) to modify autologous CD34+ cells is an emergin…
View article: Table S1 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Table S1 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Supplementary Table 1
View article: Supplementary Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Supplementary Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Supplementary Figures S1-S11
View article: Table S2 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Table S2 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Supplementary Table 2
View article: Supplementary Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Supplementary Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Supplementary Figures S1-S11
View article: Table S2 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Table S2 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Supplementary Table 2
View article: Table S1 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Table S1 from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Supplementary Table 1
View article: Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found th…
View article: Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Data from Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found th…
View article: Transitioning peanut oral immunotherapy to clinical practice
Transitioning peanut oral immunotherapy to clinical practice Open
Peanut allergy is on the rise in industrialized countries, affecting 1%–4.5% of children and generally persisting into adulthood. It is associated with a risk of severe anaphylaxis and is one of the major causes of food allergy-induced dea…
View article: Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation
Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation Open
Recipients of unconditioned HCT for SCID may develop late post-HCT T-cell exhaustion as a result of diminished production of T-lineage cells. Elevated expression of inhibitory receptors on their T cells may be a biomarker of poor long-term…
View article: Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Open
Colorectal cancer is driven by mutations that activate canonical WNT/β-catenin signaling, but inhibiting WNT has significant on-target toxicity, and there are no approved therapies targeting dominant oncogenic drivers. We recently found th…
View article: Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update
Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update Open
Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPI…
View article: Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children
Sensitivity and specificity of double-blinded penicillin skin testing in relation to oral provocation with amoxicillin in children Open
View article: Pharmacokinetic Analysis of Weekly Versus Biweekly IgPro20 Dosing in Patients With Primary Immunodeficiency
Pharmacokinetic Analysis of Weekly Versus Biweekly IgPro20 Dosing in Patients With Primary Immunodeficiency Open
Flexible dosing of IgPro20 (Hizentra®, CSL Behring, King of Prussia, Pennsylvania) maintains normal serum immunoglobulin G (IgG) levels in patients with primary immunodeficiencies (PID). Until now, clinical trials testing the pharmacokinet…
View article: Outcome of Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome
Outcome of Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome Open
Background Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by combined immunodeficiency, eczema, microthrombocytopenia, infections, autoimmunity and lymphoma. Gene therapy (GT) using autologous CD34+ cells is an em…
View article: Skin Test Boosting Effect In Amoxicillin Allergic Children
Skin Test Boosting Effect In Amoxicillin Allergic Children Open
View article: Sensitivity and Specificity of Penicillin Skin Testing for IgE-Mediated Allergy to Amoxicillin: A Double-Blinded Prospective Diagnostic Accuracy Study with Systematic Review and Meta-Analysis
Sensitivity and Specificity of Penicillin Skin Testing for IgE-Mediated Allergy to Amoxicillin: A Double-Blinded Prospective Diagnostic Accuracy Study with Systematic Review and Meta-Analysis Open
View article: Very Early-Onset Inflammatory Manifestations of X-Linked Chronic Granulomatous Disease
Very Early-Onset Inflammatory Manifestations of X-Linked Chronic Granulomatous Disease Open
Chronic granulomatous disease (CGD) is a rare primary immune deficiency caused by mutations in genes coding for components of the nicotinamide adenine dinucleotide phosphate oxidase, characterized by severe and recurrent bacterial and fung…
View article: Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016
Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016 Open
View article: Amoxicillin Reuse after a Five-Day Challenge for the Evaluation of Delayed-Type Penicillin Allergy in Children
Amoxicillin Reuse after a Five-Day Challenge for the Evaluation of Delayed-Type Penicillin Allergy in Children Open
View article: The Use of Omalizumab in Food Oral Immunotherapy
The Use of Omalizumab in Food Oral Immunotherapy Open
Food allergy is an important health issue that affects up to 8 % of the population. The management of allergic patients involves allergen avoidance and prompts the treatment of accidental reactions, as no curative treatment is available so…
View article: Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015
Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015 Open