Roxane Tussiwand
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View article: Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling
Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling Open
Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is dispensable for the maintenance of cutaneous SCC.…
View article: Notch1 sets the molecular clock for T cell development
Notch1 sets the molecular clock for T cell development Open
Notch1 signaling is instructive for T cell development, but how this single factor orchestrates commitment remains unclear. Here, by integrating multi-omics platforms, we identified 46 transcription factors (TF) that are directly regulated…
View article: Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells
Fructooligosaccharides benefits on glucose homeostasis upon high-fat diet feeding require type 2 conventional dendritic cells Open
Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enric…
View article: TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis
TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis Open
Changes in metabolism of macrophages are required to sustain macrophage activation in response to different stimuli. We showed that the cytokine TGF-β (transforming growth factor–β) regulates glycolysis in macrophages independently of infl…
View article: TGF-β promotes glycolysis through PFKL in activated macrophages and exacerbates sepsis by disrupting blood coagulation
TGF-β promotes glycolysis through PFKL in activated macrophages and exacerbates sepsis by disrupting blood coagulation Open
The metabolism of macrophages plays a key role in their immune responses, but the mechanisms by which the metabolism is regulated remain largely unknown. We show here that TGF-β induces a unique phenotype of macrophages and regulates the g…
View article: Notch2 deficiency generates functionally impaired cDCs and macrophages that correlates with intestinal dysbiosis and low-grade inflammation
Notch2 deficiency generates functionally impaired cDCs and macrophages that correlates with intestinal dysbiosis and low-grade inflammation Open
Myeloid cell types including conventional dendritic cells (cDCs) and macrophages are key responders to innate stimuli at epithelial barriers. They are equipped with innate receptors to sense danger signals and pathogens, becoming the first…
View article: Dietary fibers benefits on glucose homeostasis require type 2 conventional dendritic cells in mice fed a high-fat diet
Dietary fibers benefits on glucose homeostasis require type 2 conventional dendritic cells in mice fed a high-fat diet Open
Diet composition impacts metabolic health and is now recognized to shape the immune system, especially in the intestinal tract. Nutritional imbalance and increased caloric intake are induced by high-fat diet (HFD) in which lipids are enric…
View article: Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature
Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature Open
View article: pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells
pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells Open
Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during immune responses, ranging from initial viral control through the production of type I interferons to antigen presentation. However, recent studies uncover…
View article: Decision letter: Regulation of pDC fate determination by histone deacetylase 3
Decision letter: Regulation of pDC fate determination by histone deacetylase 3 Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Dendrit…
View article: Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells
Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells Open
Immune surveillance is critical to prevent tumorigenesis. Gliomas evade immune attack, but the underlying mechanisms remain poorly understood. We show that glioma cells can sustain growth independent of immune system constraint by reducing…
View article: Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization Open
View article: Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors
Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors Open
View article: The skin environment controls local dendritic cell differentiation and function through innate IL-13
The skin environment controls local dendritic cell differentiation and function through innate IL-13 Open
The signals driving the adaptation of type-2 dendritic cells (DC2s) to diverse peripheral environments are not well understood. We show that the development of CD11b low migratory DC2s, a DC2 population unique to the dermis, requires STAT6…
View article: Interferon-γ Resistance and Immune Evasion in Glioma Develop via Notch-Regulated Co-Evolution of Malignant and Immune Cells
Interferon-γ Resistance and Immune Evasion in Glioma Develop via Notch-Regulated Co-Evolution of Malignant and Immune Cells Open
View article: Decision letter: Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease
Decision letter: Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease Open
View article: An Important Role for CD4 <sup>+</sup> T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3
An Important Role for CD4 <sup>+</sup> T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3 Open
Toxoplasma gondii is a widespread parasite of animals that causes zoonotic infections in humans. Although healthy individuals generally control the infection with only moderate symptoms, it causes serious illness in newborns and those with…
View article: Where’s Waldo: Identifying DCs within Mononuclear Phagocytes during Inflammation
Where’s Waldo: Identifying DCs within Mononuclear Phagocytes during Inflammation Open
View article: Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells
Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells Open
View article: Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection Open
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 is crucial for protective immun…
View article: Stem Cell Imaging: Effective Labeling of Primary Somatic Stem Cells with BaTiO<sub>3</sub> Nanocrystals for Second Harmonic Generation Imaging (Small 8/2018)
Stem Cell Imaging: Effective Labeling of Primary Somatic Stem Cells with BaTiO<sub>3</sub> Nanocrystals for Second Harmonic Generation Imaging (Small 8/2018) Open
In article number 1703386, Periklis Pantazis and co-workers use Second Harmonic Generating (SHG) nanoprobes to label, with high contrast, clinically relevant hematopoietic stem cells (HSCs) by establishing an effective cell labeling proced…
View article: Effective Labeling of Primary Somatic Stem Cells with BaTiO<sub>3</sub>Nanocrystals for Second Harmonic Generation Imaging
Effective Labeling of Primary Somatic Stem Cells with BaTiO<sub>3</sub>Nanocrystals for Second Harmonic Generation Imaging Open
While nanoparticles are an increasingly popular choice for labeling and tracking stem cells in biomedical applications such as cell therapy, their intracellular fate and subsequent effect on stem cell differentiation remain elusive. To est…
View article: Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF–IRF4 transcription factor complex
Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF–IRF4 transcription factor complex Open
View article: Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate
Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate Open
Significance Distinct transcription factors regulate the development of immune cell lineages, and changes in their expression can alter the balance of cell types responding to infection. Recent studies have identified Zeb2 as a transcripti…
View article: RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells
RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells Open
In this study, to examine cross-presentation by classical dendritic cells (DCs; cDCs), we evaluated the role of RAB43, a protein found to be selectively expressed by Batf3-dependent CD8α+ and CD103+ compared with other DC subsets and immun…
View article: Transcriptional Control of Dendritic Cell Development
Transcriptional Control of Dendritic Cell Development Open
The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression…
View article: Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12 Open
CD8α+ and CD103+ dendritic cells (DCs) play a central role in the development of type 1 immune responses. However, their role in type 2 immunity remains unclear. We examined this issue using Batf3−/− mice, in which both of these DC subsets…
View article: Immunohistochemistry of spleen sections.
Immunohistochemistry of spleen sections. Open
Spleen histology of C57BL/6 mice 14 days after injection of either the non-blocking 5A12 or blocking 9B9 anti-BAFF-R mAbs, as indicated. Cryosections were stained with anti-IgM (red) and CD90 (T cells) (green), left panels, and with anti-I…
View article: Transcriptional Regulation of Mononuclear Phagocyte Development
Transcriptional Regulation of Mononuclear Phagocyte Development Open
Mononuclear phagocytes (MP) are a quite unique subset of hematopoietic cells, which comprise dendritic cells (DC), monocytes as well as monocyte-derived and tissue-resident macrophages. These cells are extremely diverse with regard to thei…
View article: Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor Open