Roxanne Dyas
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View article: Protocol for Bayesian combined multi-genotype and concentration informed tacrolimus dosing in paediatric solid organ transplantation (BRUNO-PIC)
Protocol for Bayesian combined multi-genotype and concentration informed tacrolimus dosing in paediatric solid organ transplantation (BRUNO-PIC) Open
Introduction Tacrolimus is an immunosuppressant used extensively in solid organ transplantation. Whilst highly effective in preventing organ rejection, it has a narrow range of safe and effective concentrations and wide pharmacokinetic var…
View article: Frequency and Implications of High‐Risk Pharmacogenomic Phenotypes Identified in a Diverse Australian Pediatric Oncology Cohort
Frequency and Implications of High‐Risk Pharmacogenomic Phenotypes Identified in a Diverse Australian Pediatric Oncology Cohort Open
Pharmacogenomics remains underutilized in pediatric oncology, despite the existence of evidence‐based guidelines. Implementation of pharmacogenomics‐informed prescribing could improve medication safety and efficacy in pediatric oncology pa…
View article: Phenoconversion of <i>CYP3A4</i>, <i>CYP2C19</i> and <i>CYP2D6</i> in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the <scp>PEGASUS</scp> Study
Phenoconversion of <i>CYP3A4</i>, <i>CYP2C19</i> and <i>CYP2D6</i> in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the <span>PEGASUS</span> Study Open
Phenoconversion is the discrepancy between genotype‐predicted phenotype and clinical phenotype, due to nongenetic factors. In oncology patients, the impact of phenoconversion on drug selection, efficacy, toxicity, and treatment outcomes is…
View article: <i>“</i>Validation of a novel ordinal endpoint for an adaptive platform trial in paediatric haematopoietic stem cell transplant<i>”</i>
<i>“</i>Validation of a novel ordinal endpoint for an adaptive platform trial in paediatric haematopoietic stem cell transplant<i>”</i> Open
Background Haematopoietic stem cell transplant (HCT) is a curative therapy for various paediatric conditions but is associated with significant morbidity and mortality, particularly in children requiring intensive care, facing delayed immu…
View article: Co-designing a Novel Ordinal Endpoint for an Adaptive Platform Trial, BANDICOOT, in Pediatric Hematopoietic Stem Cell Transplant
Co-designing a Novel Ordinal Endpoint for an Adaptive Platform Trial, BANDICOOT, in Pediatric Hematopoietic Stem Cell Transplant Open
An adaptive platform trial (APT) offers the ability to incorporate several research questions in the same target population across multiple domains (interventions), with the ability to add new questions in a perpetual manner. An APT is par…
View article: <i>CYP2D6</i> genotype and associated 5‐<scp>HT<sub>3</sub></scp> receptor antagonist outcomes: A systematic review and meta‐analysis
<i>CYP2D6</i> genotype and associated 5‐<span>HT<sub>3</sub></span> receptor antagonist outcomes: A systematic review and meta‐analysis Open
5‐hydroxytryptamine‐3 (5‐HT 3 ) receptor antagonists including ondansetron, tropisetron, dolasetron, palonosetron, granisetron, and ramosetron are commonly used to prevent and treat nausea and vomiting. Most of these medications are at lea…
View article: Protocol for a prospective feasibility study investigating phenoconversion of<i>CYP3A4</i>,<i>CYP2C19</i>and<i>CYP2D6</i>genotypes in paediatric and adolescent and young adult patients with an acute diagnosis of Hodgkin or Non-Hodgkin Lymphoma [PEGASUS]
Protocol for a prospective feasibility study investigating phenoconversion of<i>CYP3A4</i>,<i>CYP2C19</i>and<i>CYP2D6</i>genotypes in paediatric and adolescent and young adult patients with an acute diagnosis of Hodgkin or Non-Hodgkin Lymphoma [PEGASUS] Open
Introduction Phenoconversion is the discrepancy between the predicted phenotype based on genotyping (genotype-based phenotype) and the actual phenotype influenced by non-genetic factors (clinical phenotype). Despite its potential impact on…
View article: Minimising Adverse Drug Reactions and Verifying Economic Legitimacy-Pharmacogenomics Implementation in Children (MARVEL- PIC): protocol for a national randomised controlled trial of pharmacogenomics implementation
Minimising Adverse Drug Reactions and Verifying Economic Legitimacy-Pharmacogenomics Implementation in Children (MARVEL- PIC): protocol for a national randomised controlled trial of pharmacogenomics implementation Open
Introduction DNA-informed prescribing (termed pharmacogenomics, PGx) is the epitome of personalised medicine. Despite international guidelines existing, its implementation in paediatric oncology remains sparse. Methods and analysis Minimis…