Roxanne Hook
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View article: Author Correction: The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors
Author Correction: The impact of the initial COVID-19 outbreak on young adults’ mental health: a longitudinal study of risk and resilience factors Open
Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-022-21053-2, published online 05 October 2022. The original version of this Article contained an omission in the Methods section, under the subheading ‘Risk factors’. “A detai…
View article: Feasibility, tolerability, and first experience of intracystic treatment with peginterferon alfa-2a in patients with cystic craniopharyngioma
Feasibility, tolerability, and first experience of intracystic treatment with peginterferon alfa-2a in patients with cystic craniopharyngioma Open
Background Children with craniopharyngiomas (CPs) typically suffer from a life-long chronic disease. The younger the child, the more vulnerable the maturing brain is to invasive therapies such as surgery or radiotherapy. Therefore, treatme…
View article: CP-07. FEASIBILITY, TOLERABILITY AND FIRST EXPERIENCE OF INTRACYSTIC TREATMENT WITH PEGINTERFERON ALFA-2A IN PATIENTS WITH CYSTIC CRANIOPHARYNGIOMA
CP-07. FEASIBILITY, TOLERABILITY AND FIRST EXPERIENCE OF INTRACYSTIC TREATMENT WITH PEGINTERFERON ALFA-2A IN PATIENTS WITH CYSTIC CRANIOPHARYNGIOMA Open
BACKGROUND Craniopharyngiomas (CP) is a life-long chronic disease predominantly affecting young children. Consequently, the developing brain is particularly sensitive to therapies such as surgery or radiotherapy. Hence, therapies allowing …
View article: Cohort Profile Update: The Neuroscience in Psychiatry Network (NSPN) 2400 cohort during the COVID-19 pandemic
Cohort Profile Update: The Neuroscience in Psychiatry Network (NSPN) 2400 cohort during the COVID-19 pandemic Open
The Neuroscience in Psychiatry Network (NSPN) 2400 cohort (n 2403; aged 14-24 years at baseline) was conceived in 2012 to support an accelerated longitudinal design to study the emergence of psychopathology and psychiatric disorders across…
View article: Why Is Non-suicidal Self-injury More Common in Women? Mediation and Moderation Analyses of Psychological Distress, Emotion Dysregulation, and Impulsivity
Why Is Non-suicidal Self-injury More Common in Women? Mediation and Moderation Analyses of Psychological Distress, Emotion Dysregulation, and Impulsivity Open
OBJECTIVE: Non-suicidal self-injury (NSSI) appears to be more common among women than men, though the underlying reasons for this remain unclear. In a community sample of young adults (N = 996, aged 18-33) assessed during the COVID-19 pand…
View article: Cortical dopamine reduces the impact of motivational biases governing automated behaviour
Cortical dopamine reduces the impact of motivational biases governing automated behaviour Open
Motivations shape our behaviour: the promise of reward invigorates, while in the face of punishment, we hold back. Abnormalities of motivational processing are implicated in clinical disorders characterised by excessive habits and loss of …
View article: Tolcapone in obsessive-compulsive disorder: a randomized double-blind placebo-controlled crossover trial
Tolcapone in obsessive-compulsive disorder: a randomized double-blind placebo-controlled crossover trial Open
Despite the availability of evidence-based treatments for obsessive-compulsive disorder (OCD), not all patients experience sufficient benefit or are able to tolerate them. Tolcapone is a catechol-O-methyl-transferase (COMT) enzyme inhibito…
View article: Why is non-suicidal self-injury more prevalent among women? Mediation and moderation analyses of psychological distress, emotion dysregulation, and impulsivity
Why is non-suicidal self-injury more prevalent among women? Mediation and moderation analyses of psychological distress, emotion dysregulation, and impulsivity Open
Objective Non-suicidal self-injury (NSSI) appears to be more common among women than men, though the underlying reasons for this remain unclear. In a community sample of young adults ( n =996, aged 18-30) assessed during the COVID-19 pande…
View article: Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours Open
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic ‘disin…
View article: Associations between inattention and impulsivity ADHD symptoms and disordered eating risk in a community sample of young adults
Associations between inattention and impulsivity ADHD symptoms and disordered eating risk in a community sample of young adults Open
Background Symptoms of attention deficit hyperactivity disorder (ADHD) and trait impulsivity have been associated with disordered eating but are seldom assessed in community studies, or longitudinally and little is known about the mediatin…
View article: Eating disorders with over-exercise: A cross-sectional analysis of the mediational role of problematic usage of the internet in young people
Eating disorders with over-exercise: A cross-sectional analysis of the mediational role of problematic usage of the internet in young people Open
Eating disorders are widespread illnesses with significant global impact. There is growing concern about how young people overuse online resources leading to mental health sequelae. We gathered data from 639 individuals from a population c…
View article: The impact of an epilepsy nurse competency framework on the costs of supporting adults with epilepsy and intellectual disability: findings from the EpAID study
The impact of an epilepsy nurse competency framework on the costs of supporting adults with epilepsy and intellectual disability: findings from the EpAID study Open
Background The development of a nurse‐led approach to managing epilepsy in adults with an intellectual disability (ID) offers the potential of improved outcomes and lower costs of care. We undertook a cluster randomised trial to assess the…
View article: Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations
Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations Open
Objective: Young adulthood is a crucial neurodevelopmental period during which impulsive and compulsive problem behaviours commonly emerge. While traditionally considered diametrically opposed, impulsive and compulsive symptoms tend to co-…
View article: Impulsivity in Gambling Disorder and problem gambling: a meta-analysis
Impulsivity in Gambling Disorder and problem gambling: a meta-analysis Open
Gambling Disorder is a prevalent psychiatric condition often linked to dysfunction of cognitive domains regulating impulsive behavior. Despite the centrality of impulsivity to neurobiological models of Gambling Disorder, a comprehensive me…
View article: Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations
Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations Open
Objective Young adulthood is a crucial neurodevelopmental period during which impulsive and compulsive problem behaviours commonly emerge. While traditionally considered diametrically opposed, impulsive and compulsive symptoms tend to co-o…
View article: Cognitive deficits in problematic internet use: meta-analysis of 40 studies
Cognitive deficits in problematic internet use: meta-analysis of 40 studies Open
Background Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various methodological l…
View article: Training nurses in a competency framework to support adults with epilepsy and intellectual disability: the EpAID cluster RCT
Training nurses in a competency framework to support adults with epilepsy and intellectual disability: the EpAID cluster RCT Open
Background People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rate…
View article: Additional file 1: of Improving outcomes in adults with epilepsy and intellectual disability (EpAID) using a nurse-led intervention: study protocol for a cluster randomised controlled trial
Additional file 1: of Improving outcomes in adults with epilepsy and intellectual disability (EpAID) using a nurse-led intervention: study protocol for a cluster randomised controlled trial Open
EpAID Trial SPIRIT checklist. (XLSX 11 kb)