Roy A. Meoded
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Evolution-guided engineering of <i>trans</i> -acyltransferase polyketide synthases Open
Bacterial multimodular polyketide synthases (PKSs) are giant enzymes that generate a wide range of therapeutically important but synthetically challenging natural products. Diversification of polyketide structures can be achieved by engine…
Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases Open
Data underlying the manuscript 'Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases' by Mabesoone, Leopold-Messer and Minas et al. The repository contains: Sequencing data - Genbanks files of construct designs, ab1 a…
Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases Open
Data underlying the manuscript 'Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases' by Mabesoone, Leopold-Messer and Minas et al. The repository contains: Sequencing data - Genbanks files of construct designs, ab1 a…
Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases Open
Data underlying the manuscript 'Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases' by Mabesoone, Leopold-Messer and Minas et al. The repository contains: Sequencing data - Genbanks files of construct designs, ab1 a…
Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases Open
Data underlying the manuscript 'Evolution-Guided Engineering of Trans-Acyltransferase Polyketide Synthases' by Mabesoone, Leopold-Messer and Minas et al. The repository contains: Sequencing data - Genbanks files of construct designs, ab1 a…
Front Cover: Characterization of an Unusual α‐Oxoamine Synthase Off‐Loading Domain from a Cyanobacterial Type I Fatty Acid Synthase (ChemBioChem 18/2023) Open
A new fatty acid synthase off-loading domain. Fatty acid synthase (FAS) usually releases its products by hydrolysis or transesterification. Here, an α-oxoamine synthase off-loading domain is identified in a cyanobacterial type I FAS. This …
Characterization of an Unusual α‐Oxoamine Synthase Off‐Loading Domain from a Cyanobacterial Type I Fatty Acid Synthase Open
Type I fatty acid synthases (FASs) are known from higher eukaryotes and fungi. We report the discovery of FasT, a rare type I FAS from the cyanobacterium Chlorogloea sp. CCALA695. FasT possesses an unusual off‐loading domain, which was het…
1080 Using site-specific chemical conjugation to generate superior half-life extended or PD-1-targeted formats of a potent IL-18 variant resistant to IL-18 binding protein Open
Background Interleukin-18 (IL-18) is a pro-inflammatory cytokine able to trigger both innate as well as adaptive immune responses. IL-18 is a potent amplifier of IFNg signaling which induces pleiotropic Th1 responses, making it an attracti…
Structure of a Promiscuous Thioesterase Domain Responsible for Branching Acylation in Polyketide Biosynthesis Open
Thioesterases (TEs) are fundamentally important enzymes present in all bacteria and eukaryotes, where they have conserved functions in fatty acid biosynthesis and secondary metabolism. This work provides the first structural insights into …
Corrigendum: Genome Mining of Oxidation Modules in <i>trans</i>‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides Open
In the abstract and on page 7763 of this Communication, the authors erroneously describe Gynuella sunshinyii as the first culturable source for lobatamides. However, Suzumura et al. reported in 1997 the isolation of the compound YM-75518, …
Genome Mining of Oxidation Modules in <i>trans</i>‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides Open
Bacterial trans ‐acyltransferase polyketide synthases ( trans ‐AT PKSs) are multimodular megaenzymes that biosynthesize many bioactive natural products. They contain a remarkable range of domains and module types that introduce different s…
Genome Mining of Oxidation Modules in <i>trans</i>‐Acyltransferase Polyketide Synthases Reveals a Culturable Source for Lobatamides Open
Bacterial trans ‐acyltransferase polyketide synthases ( trans ‐AT PKSs) are multimodular megaenzymes that biosynthesize many bioactive natural products. They contain a remarkable range of domains and module types that introduce different s…
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones Open
Enzymatic core components from trans ‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygen…
View article: ‘ <i>In plaque</i> -mass spectrometry imaging’ reveals a major metabolic shift towards odd-chain fatty acid lipids induced by host-virus interactions
‘ <i>In plaque</i> -mass spectrometry imaging’ reveals a major metabolic shift towards odd-chain fatty acid lipids induced by host-virus interactions Open
Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into …
Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated <i>Entotheonella</i> sponge symbionts Open
Marine sponges are prolific sources of unique bioactive natural products. The sponge Theonella swinhoei is represented by several distinct variants with largely nonoverlapping chemistry. For the Japanese chemotype Y harboring diverse compl…
CCDC 1470874: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 1470873: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …