Roy A. Pleasants
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View article: Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i>
Reply to Liu <i>et al.</i>, Zhou <i>et al.</i>, and Dong <i>et al.</i> Open
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View article: Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach
Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach Open
T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum th…
View article: Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)
Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR) Open
OCS, whether prescribed intermittently or long term, affect BEC distribution potentially leading to heightened risk of phenotype misclassification and influencing subsequent treatment decisions. FeNO appears to be less susceptible to OCS-i…
View article: Predictive machine learning algorithm for COPD exacerbations using a digital inhaler with integrated sensors
Predictive machine learning algorithm for COPD exacerbations using a digital inhaler with integrated sensors Open
PURPOSE: By using data obtained with digital inhalers, machine learning models have the potential to detect early signs of deterioration and predict impending exacerbations of chronic obstructive pulmonary disease (COPD) for individual pat…
View article: Predictive machine learning algorithm for COPD exacerbations using a digital inhaler with integrated sensors
Predictive machine learning algorithm for COPD exacerbations using a digital inhaler with integrated sensors Open
Purpose By using data obtained with digital inhalers, machine learning models have the potential to detect early signs of deterioration and predict impending exacerbations of chronic obstructive pulmonary disease (COPD) for individual pati…
View article: A Predictive Machine Learning Tool for Asthma Exacerbations: Results from a 12-Week, Open-Label Study Using an Electronic Multi-Dose Dry Powder Inhaler with Integrated Sensors
A Predictive Machine Learning Tool for Asthma Exacerbations: Results from a 12-Week, Open-Label Study Using an Electronic Multi-Dose Dry Powder Inhaler with Integrated Sensors Open
Purpose: Machine learning models informed by sensor data inputs have the potential to provide individualized predictions of asthma deterioration. This study aimed to determine if data from an integrated digital inhaler could be used to dev…
View article: International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update
International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update Open
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As the first global registry for adults with severe asthma,…
View article: Effect of Physical Position on Peak Inspiratory Flow in Stable COPD: An Observational Study
Effect of Physical Position on Peak Inspiratory Flow in Stable COPD: An Observational Study Open
PIF was significantly affected by physical position regardless of DPI resistance. PIF was highest when standing and lowest when semi-upright. We recommend that patients with COPD stand while using an R2 or R5 DPI. Where unfeasible, the pos…
View article: Current Perspective of the Drug-Drug Interaction between Inhaled Medicines and Nirmatrelvir/Ritonavir
Current Perspective of the Drug-Drug Interaction between Inhaled Medicines and Nirmatrelvir/Ritonavir Open
View article: Current Perspectives of Pharmacotherapies for COPD
Current Perspectives of Pharmacotherapies for COPD Open
Pharmacotherapies and avoidance of environmental/inhaled toxins are core to managing COPD. Compared to the drugs available 50 years ago, there has been substantial progress with COPD pharmacotherapies, but gaps in adherence and inhaler use…
View article: Questions in Mild Asthma: An Official American Thoracic Society Research Statement
Questions in Mild Asthma: An Official American Thoracic Society Research Statement Open
Background: Patients with mild asthma are believed to represent the majority of patients with asthma. Disease-associated risks such as exacerbations, lung function decline, and death have been understudied in this patient population…
View article: Integrating digital inhalers into clinical care of patients with asthma and chronic obstructive pulmonary disease
Integrating digital inhalers into clinical care of patients with asthma and chronic obstructive pulmonary disease Open
Modernizing inhaled medications through digital technology can help address persistent problems of non-adherence and poor inhaler technique in patients with obstructive lung diseases. With a growing body of supportive clinical studies, adv…
View article: A Predictive Machine Learning Tool for Asthma Exacerbations: Results from a 12-Week, Open-Label Study Using an Electronic Multi-Dose Dry Powder Inhaler with Integrated Sensors
A Predictive Machine Learning Tool for Asthma Exacerbations: Results from a 12-Week, Open-Label Study Using an Electronic Multi-Dose Dry Powder Inhaler with Integrated Sensors Open
A machine learning model to predict impending asthma exacerbations using data from the eMDPI was successfully developed. This approach may support a shift from reactive care to proactive, preventative, and personalized management of chroni…
View article: Not All Inhaled Medicines Are Equal
Not All Inhaled Medicines Are Equal Open
View article: The Eyes Have It—for Idiopathic Pulmonary Fibrosis: a Preliminary Observation
The Eyes Have It—for Idiopathic Pulmonary Fibrosis: a Preliminary Observation Open
View article: Respiratory Symptoms among US Adults: a Cross-Sectional Health Survey Study
Respiratory Symptoms among US Adults: a Cross-Sectional Health Survey Study Open
View article: Measuring Peak Inspiratory Flow in Patients with Chronic Obstructive Pulmonary Disease
Measuring Peak Inspiratory Flow in Patients with Chronic Obstructive Pulmonary Disease Open
Dry powder inhalers (DPIs) are breath actuated, and patients using DPIs need to generate an optimal inspiratory flow during the inhalation maneuver for effective drug delivery to the lungs. However, practical and standardized recommendatio…
View article: Respiratory Symptoms Among US Adults
Respiratory Symptoms Among US Adults Open
View article: Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective
Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective Open
Impressive advances in inhalation therapy for patients with asthma and chronic obstructive pulmonary disease (COPD) have occurred in recent years. However, important gaps in care remain, particularly relating to poor adherence to inhaled t…
View article: A 24-Week Study of Home Peak Inspiratory Flow Measurements in COPD Patients
A 24-Week Study of Home Peak Inspiratory Flow Measurements in COPD Patients Open
RATIONALE: Peak inspiratory flow (PIF) has been shown to be suboptimal in some hospitalized and outpatient clinic COPD populations.Data is lacking regarding prevalence of suboptimal PIF (sPIF) in ambulatory COPD patients.METHODS: We undert…
View article: Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study
Interstitial lung disease in a veterans affairs regional network; a retrospective cohort study Open
Background The epidemiology of Interstitial Lung Diseases (ILD) in the Veterans Health Administration (VHA) is presently unknown. Research question Describe the incidence/prevalence, clinical characteristics, and outcomes of ILD patients w…
View article: Effect of OM-85 BV on reducing bronchiectasis exacerbation in Chinese patients: the iPROBE study
Effect of OM-85 BV on reducing bronchiectasis exacerbation in Chinese patients: the iPROBE study Open
OM-85 BV did not demonstrate protection in decreasing pulmonary exacerbations of bronchiectasis in this trial performed in Chinese patients. It had good safety profile.
View article: User-life of ICS/LABA inhaler devices should be considered when prescribed as relievers
User-life of ICS/LABA inhaler devices should be considered when prescribed as relievers Open
Prescribers and asthma patients should know that ICS/LABA combination inhalers used as reliever therapy may expire under patient use sooner than the expiration shown on the inhaler, compromising effectiveness if not considered by the pr…
View article: Pharmacokinetics of vancomycin in adult cystic fibrosis patients.
Pharmacokinetics of vancomycin in adult cystic fibrosis patients. Open
Although the depositions of many antibiotics are altered in cystic fibrosis patients, that of vancomycin has not been studied. To assess vancomycin pharmacokinetics, 10 adult cystic fibrosis patients were given a parenteral dose of vancomy…
View article: A population-based estimate of the health care burden of obstructive sleep apnea using a STOP-BAG questionnaire in South Carolina
A population-based estimate of the health care burden of obstructive sleep apnea using a STOP-BAG questionnaire in South Carolina Open
View article: INHALATION PARAMETERS IN PATIENTS WITH ASTHMA USING ALBUTEROL ELECTRONIC MULTI-DOSE DRY POWDER INHALER
INHALATION PARAMETERS IN PATIENTS WITH ASTHMA USING ALBUTEROL ELECTRONIC MULTI-DOSE DRY POWDER INHALER Open
View article: REMOTELY RECORDED PEAK INHALATION FLOW PATTERNS AMONG PATIENTS WITH COPD USING PROAIR DIGIHALER FOR RESCUE MEDICATION
REMOTELY RECORDED PEAK INHALATION FLOW PATTERNS AMONG PATIENTS WITH COPD USING PROAIR DIGIHALER FOR RESCUE MEDICATION Open
View article: AN UPDATED MODEL FOR PREDICTION OF ASTHMA EXACERBATIONS USING ALBUTEROL ELECTRONIC MULTI-DOSE DRY POWDER INHALER
AN UPDATED MODEL FOR PREDICTION OF ASTHMA EXACERBATIONS USING ALBUTEROL ELECTRONIC MULTI-DOSE DRY POWDER INHALER Open
View article: A Scoping Review of International Barriers to Asthma Medication Adherence Mapped to the Theoretical Domains Framework
A Scoping Review of International Barriers to Asthma Medication Adherence Mapped to the Theoretical Domains Framework Open
View article: Procalcitonin for Antibiotic Prescription in Chronic Obstructive Pulmonary Disease Exacerbations: Systematic Review, Meta-Analysis, and Clinical Perspective
Procalcitonin for Antibiotic Prescription in Chronic Obstructive Pulmonary Disease Exacerbations: Systematic Review, Meta-Analysis, and Clinical Perspective Open