Roy Beigel
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View article: Frailty Modifies the Prognostic Effect of Age Among Older Adults With Acute Coronary Syndrome
Frailty Modifies the Prognostic Effect of Age Among Older Adults With Acute Coronary Syndrome Open
Background An increasing number of older adults have been hospitalized in cardiac intensive care units. Their more complex medical profiles and frailty dictate treatment decisions and affect outcomes. There is no universally agreed‐upon ag…
View article: Neutrophil‐to‐lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum
Neutrophil‐to‐lymphocyte ratio for risk stratification in acute myocarditis across the left ventricular ejection fraction spectrum Open
Aims Acute myocarditis (AM) is a heterogeneous clinical condition. Several classification models have been proposed to predict adverse clinical outcomes, but risk stratification remains challenging, particularly for patients presenting wit…
View article: Heart as white as stone, reborn: an unusual case report of idiopathic myocardial calcifications leading to end-stage heart failure and cardiac transplantation
Heart as white as stone, reborn: an unusual case report of idiopathic myocardial calcifications leading to end-stage heart failure and cardiac transplantation Open
Background Massive myocardial calcifications without an underlying cause are a rare entity of unknown pathophysiology that could result in heart failure with preserved ejection fraction and restrictive physiology. The role of heart transpl…
View article: Intermediate-Risk Pulmonary Embolism: Patients’ Stratification, Prognosis, and Therapeutic Options—Time to Pay Attention to the Middle Child
Intermediate-Risk Pulmonary Embolism: Patients’ Stratification, Prognosis, and Therapeutic Options—Time to Pay Attention to the Middle Child Open
Acute pulmonary embolism can range from being completely asymptomatic to causing life-threatening events, which underscores the importance of effective risk stratification. Intermediate-risk patients represent a distinct subgroup character…
View article: Impact of Transport Method in Patients With ST‐Segment–Elevation Myocardial Infarction on Patient Outcomes: Real‐World Data From the ACSIS Registry
Impact of Transport Method in Patients With ST‐Segment–Elevation Myocardial Infarction on Patient Outcomes: Real‐World Data From the ACSIS Registry Open
Background The ambulance system is vital for the early management of patients with ST‐segment–elevation myocardial infarction, reducing delays in diagnosis and treatment. This study examined the impact of transport mode on reperfusion ther…
View article: Heart failure with supranormal ejection fraction: clinical characteristics and outcomes compared to mildly reduced and preserved ejection fraction
Heart failure with supranormal ejection fraction: clinical characteristics and outcomes compared to mildly reduced and preserved ejection fraction Open
Background Little is known about the recently emerging entity, heart failure with supranormal ejection fraction (HFsnEF). Objective To describe the clinical characteristics and outcome of HFsnEF, compared to HF with mildly reduced EF (HFmr…
View article: Intra‐Aortic Balloon Pump: Overall and Temporal Trends of Comparative Effectiveness in a National Registry
Intra‐Aortic Balloon Pump: Overall and Temporal Trends of Comparative Effectiveness in a National Registry Open
Background Although the latest studies failed to prove the benefit of routine intra‐aortic balloon pump (IABP) use in patients with acute myocardial infarction (MI) presenting with cardiogenic shock, the benefit of IABP utilization in sele…
View article: Looking Back, Leaning Forward—A Contemporary Overview of Acute Coronary Syndrome
Looking Back, Leaning Forward—A Contemporary Overview of Acute Coronary Syndrome Open
Cardiovascular disease (CVD) remains the most common cause of morbidity and mortality worldwide [...]
View article: Temporal Trends in Patient Characteristics and Clinical Outcomes of TAVR: Over a Decade of Practice
Temporal Trends in Patient Characteristics and Clinical Outcomes of TAVR: Over a Decade of Practice Open
Background/Objective: Transcatheter aortic valve replacement (TAVR) is indicated for severe aortic stenosis patients with a prohibitive surgical risk. However, its use has been expanding in recent years to include intermediate- and low-ris…
View article: P2Y12 adenosine receptor inhibitors preloading among patients with non‐ST‐elevation acute coronary syndromes; insights from a nationwide multicenter registry
P2Y12 adenosine receptor inhibitors preloading among patients with non‐ST‐elevation acute coronary syndromes; insights from a nationwide multicenter registry Open
Background The safety and efficacy of treatment with P2Y12 adenosine‐diphosphate receptor inhibitors (P2Y12‐RI) before coronary angiography among patients with non‐ST‐segment elevation acute coronary syndromes (NSTEACS) are questionable. A…
View article: Temporal trends in all-cause and cause-specific mortality following non-ST-elevation myocardial infarction in Israel, 2000-2013
Temporal trends in all-cause and cause-specific mortality following non-ST-elevation myocardial infarction in Israel, 2000-2013 Open
Background International studies report a decline in 30-day and 180-day all-cause mortality after non-ST-elevation myocardial infarction (NSTEMI). However, studies on temporal trends of more extended follow-up periods after NSTEMI are lack…
View article: Clinical predictors of left ventricular thrombus after myocardial infarction as detected by magnetic resonance imaging
Clinical predictors of left ventricular thrombus after myocardial infarction as detected by magnetic resonance imaging Open
Background The diagnosis of a left ventricular (LV) thrombus in patients with ST-segment elevation myocardial infarction (STEMI) remains challenging. The aim of the current study is to characterize clinical predictors for LV thrombus forma…
View article: Temporal trends in intra-aortic balloon pump use
Temporal trends in intra-aortic balloon pump use Open
Background Intra-aortic balloon pump (IABP) is still the most accessible and available mechanical support solution in acute myocardial infarction patients, especially in cardiogenic shock. Although studies from the last decade failed to pr…
View article: Evidence-based heart failure therapies at discharge of patients with acute coronary syndromes and reduced ejection fraction: Data from the ACSIS survey
Evidence-based heart failure therapies at discharge of patients with acute coronary syndromes and reduced ejection fraction: Data from the ACSIS survey Open
Background Guideline-directed medical therapies for heart failure (HF) may benefit patients with reduced left ventricular ejection fraction (LVEF) following acute coronary syndromes (ACS), even in the absence of overt HF. Few real-world da…
View article: Sex differences in ventricular arrhythmia, atrial fibrillation and atrioventricular block complicating acute myocardial infarction
Sex differences in ventricular arrhythmia, atrial fibrillation and atrioventricular block complicating acute myocardial infarction Open
Background Acute myocardial infarction (AMI) complicated by tachyarrhythmias or high-grade atrioventricular block (HAVB) may lead to increased mortality. Purpose To evaluate the sex differences in patients with AMI complicated by tachyarrh…
View article: BNT162b2‐vaccine‐induced neutralization responses are immune correlates of clinical protection against SARS‐CoV‐2 in heart transplant recipients
BNT162b2‐vaccine‐induced neutralization responses are immune correlates of clinical protection against SARS‐CoV‐2 in heart transplant recipients Open
Background Defining immune correlates of protection against COVID‐19 is pivotal for optimizing the use of COVID‐19 vaccines, predicting the impact of novel variants on clinical outcomes, and advancing the development of immunotherapies and…
View article: Heart Failure Therapies following Acute Coronary Syndromes with Reduced Ejection Fraction: Data from the ACSIS Survey
Heart Failure Therapies following Acute Coronary Syndromes with Reduced Ejection Fraction: Data from the ACSIS Survey Open
Background: Guideline-directed medical therapies for heart failure (HF) may benefit patients with reduced left ventricular ejection fraction (LVEF) following acute coronary syndromes (ACS). Few real-world data are available regarding the e…
View article: Incidence and clinical predictors of left ventricular thrombus after ST elevation myocardial infarction as detected by magnetic resonance imaging
Incidence and clinical predictors of left ventricular thrombus after ST elevation myocardial infarction as detected by magnetic resonance imaging Open
Funding Acknowledgements Type of funding sources: None. Background The aim of the current study was to characterize clinical predictors and to develop clinical risk score for left ventricular (LV) thrombus as detected by cardiac magnetic r…
View article: The burden of heart failure in cardiac intensive care unit: a prospective 7 years analysis
The burden of heart failure in cardiac intensive care unit: a prospective 7 years analysis Open
Aims The profiles of patients at cardiac intensive care units (CICU) have evolved towards a patient population with an increasing number of co‐morbid medical conditions and acute heart failure (HF). The current study was designed to illust…
View article: The obesity paradox in patients with acute coronary syndromes – is it still applicable to the current era? The ACSIS registry 2000–2018
The obesity paradox in patients with acute coronary syndromes – is it still applicable to the current era? The ACSIS registry 2000–2018 Open
Background Obesity is a major epidemic which is associated with major cardiovascular (CV) risk factors. Nevertheless, substantial data, mostly published more than a decade ago, have demonstrated an obesity paradox, where obese patients gen…
View article: Outcomes among patients admitted for non-ST-segment myocardial infarction in the pre-pandemic and pandemic COVID-19 era: Israel Nationwide study
Outcomes among patients admitted for non-ST-segment myocardial infarction in the pre-pandemic and pandemic COVID-19 era: Israel Nationwide study Open
Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic in 2019, several countries have reported a substantial drop in the number of patients admitted with non-ST-segment myocardial infarction (NSTEMI). Objective…
View article: Peripheral artery disease, abnormal ankle-brachial index, and prognosis in patients with acute coronary syndrome
Peripheral artery disease, abnormal ankle-brachial index, and prognosis in patients with acute coronary syndrome Open
Objectives Ankle-brachial index (ABI) is an independent prognostic marker of cardiovascular events among patients with coronary artery disease (CAD). We aimed to investigate the outcome of patients hospitalized with acute coronary syndrome…
View article: The Impact of Novel Anti-Diabetic Medications on CV Outcomes: A New Therapeutic Horizon for Diabetic and Non-Diabetic Cardiac Patients
The Impact of Novel Anti-Diabetic Medications on CV Outcomes: A New Therapeutic Horizon for Diabetic and Non-Diabetic Cardiac Patients Open
It is estimated that in the past two decades the number of patients diagnosed with diabetes mellites (DM) has doubled. Despite significant progress in the treatment of cardiovascular disease (CVD), including novel anti-platelet agents, eff…
View article: Immediate and early percutaneous coronary intervention in very high‐risk and high‐risk non‐ST segment elevation myocardial infarction patients
Immediate and early percutaneous coronary intervention in very high‐risk and high‐risk non‐ST segment elevation myocardial infarction patients Open
Background The European Society of Cardiology (ESC) guidelines for the management of acute coronary syndromes in patients presenting without persistent ST‐segment elevation (non‐ST‐segment elevation myocardial infarction [NSTEMI]) has reco…
View article: Post–ST‐Segment–Elevation Myocardial Infarction Platelet Reactivity Is Associated With the Extent of Microvascular Obstruction and Infarct Size as Determined by Cardiac Magnetic Resonance Imaging
Post–ST‐Segment–Elevation Myocardial Infarction Platelet Reactivity Is Associated With the Extent of Microvascular Obstruction and Infarct Size as Determined by Cardiac Magnetic Resonance Imaging Open
Background Despite optimized medical management and techniques of primary percutaneous coronary intervention, a substantial proportion of patients with ST‐segment–elevation myocardial infarction (STEMI) display significant microvascular da…