Roy Bicknell
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View article: Towards active vaccination against tumour endothelial marker Robo4
Towards active vaccination against tumour endothelial marker Robo4 Open
Targeting tumour antigens is a major challenge in cancer-immunotherapy. We use active vaccination to induce antibodies targeting self-antigen Robo4, which is selectively expressed on tumour vascular endothelium, supporting vascular develop…
View article: Supplementary Table and Figure 1 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table and Figure 1 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 1: Primer sequences for RTqPCR using the Roche Exiqon probe library system. Supplementary Figure 1. Representative images demonstrative of scoring for staining intensity. Images are of MCAM staining in RCC at a weak (i-…
View article: Supplementary Table 11 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 11 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 11: Key clinical data for the CRC cohort showing overall survival (OS)
View article: Supplementary Table 5 and 6 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 5 and 6 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 5: Matrix metallopeptidase regulation across tissue types (Gene expression comparison shown as Log2 fold change) Supplementary Table 6: Collagen regulation across tissue types (Gene expression comparison shown as Log2 f…
View article: Data from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Data from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Antiangiogenic therapies have failed to confer survival benefits in patients with metastatic breast cancer (mBC). However, to date, there has not been an inquiry into the roles for acquired versus innate drug resistance in this setting. In…
View article: Supplementary tables 2,3 and 4 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary tables 2,3 and 4 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Supplementary table 2. Expression change of genes on which sunitinib has a known or predicted effect, in tumour bulk harvested at each time-point. Log2 fold change in gene expression shown. Supplementary table 3. Expression change of genes…
View article: Supplementary figure 3 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary figure 3 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Representative tumours from the non-responsive (square), responsive (circle) and untreated (cross) group at each time period, were subjected to microarray transcriptomic analysis. Graphs showing individual tumour growth data points and mea…
View article: Data from FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism
Data from FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism Open
Purpose: Antiangiogenic therapies can be an important adjunct to the management of many malignancies. Here we investigated a novel protein, FKBPL, and peptide derivative for their antiangiogenic activity and mechanism of action.Experimenta…
View article: Supplementary Data from FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism
Supplementary Data from FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism Open
Supplementary Figures S1-S10; Supplementary Table S1.
View article: Data from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Data from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
The structure and molecular signature of tumor-associated vasculature are distinct from those of the host tissue, offering an opportunity to selectively target the tumor blood vessels. To identify tumor-specific endothelial markers, we per…
View article: Supplementary Table 8 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 8 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 8: Key clinical data for clear cell RCC cohort 1, showing overall survival (OS)
View article: Supplementary table 1 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary table 1 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Murine RTqPCR primers used for the research detailed in this paper.
View article: Supplementary Table 10 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 10 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 10: Key clinical data for clear cell RCC cohort 3 showing overall survival (OS).
View article: Supplementary Table 11 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 11 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 11: Key clinical data for the CRC cohort showing overall survival (OS)
View article: Supplementary Data from FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism
Supplementary Data from FKBPL and Peptide Derivatives: Novel Biological Agents That Inhibit Angiogenesis by a CD44-Dependent Mechanism Open
Supplementary Figures S1-S10; Supplementary Table S1.
View article: Data from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Data from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
The structure and molecular signature of tumor-associated vasculature are distinct from those of the host tissue, offering an opportunity to selectively target the tumor blood vessels. To identify tumor-specific endothelial markers, we per…
View article: Supplementary Table 8 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 8 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 8: Key clinical data for clear cell RCC cohort 1, showing overall survival (OS)
View article: Supplementary Table and Figure 1 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table and Figure 1 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 1: Primer sequences for RTqPCR using the Roche Exiqon probe library system. Supplementary Figure 1. Representative images demonstrative of scoring for staining intensity. Images are of MCAM staining in RCC at a weak (i-…
View article: Supplementary table 5 and 6 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary table 5 and 6 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Supplementary table 5. Expression change of genes that enhance metastasis in tumour bulk harvested at 1300 mm3. Log2 fold change in gene expression shown. Supplementary table 6. Expression change of genes that enhance endothelial migration…
View article: Supplementary table 1 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary table 1 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Murine RTqPCR primers used for the research detailed in this paper.
View article: Supplementary Tables 2, 3 and 4 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Tables 2, 3 and 4 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 2: Clinical-pathological data for colorectal cancer patients used for genomic analysis and validation Supplementary Table 3: Clinical-pathological data for colorectal liver metastasis patients used for genomic analysis …
View article: Supplementary figure 2 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary figure 2 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Endothelial isolation from murine breast tumours. A, workflow of the main steps involved in the murine endothelial cell isolation procedure. B, RTqPCR for markers of leukocytes (CD11b), macrophages (CD68), epithelium (EPCAM), smooth muscle…
View article: Supplementary table 5 and 6 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary table 5 and 6 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Supplementary table 5. Expression change of genes that enhance metastasis in tumour bulk harvested at 1300 mm3. Log2 fold change in gene expression shown. Supplementary table 6. Expression change of genes that enhance endothelial migration…
View article: Supplementary figure 1 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary figure 1 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Sunitinib resistance inheritance. Tumour cells were isolated from 4T1 tumours displaying acquired (responsive cohort) or innate (non-responsive cohort) resistance to sunitinib treatment in vivo and cultured for 2 weeks. A, tumour growth cu…
View article: Supplementary Table 7 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome
Supplementary Table 7 from MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome Open
Supplementary Table 7: Key clinical data for different types of kidney cancer and metastasis
View article: Supplementary figure 3 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Supplementary figure 3 from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Representative tumours from the non-responsive (square), responsive (circle) and untreated (cross) group at each time period, were subjected to microarray transcriptomic analysis. Graphs showing individual tumour growth data points and mea…
View article: Data from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors
Data from Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors Open
Antiangiogenic therapies have failed to confer survival benefits in patients with metastatic breast cancer (mBC). However, to date, there has not been an inquiry into the roles for acquired versus innate drug resistance in this setting. In…
View article: Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density
Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density Open
Supplementary Figure 1 from Expression of Terminally Glycosylated Calcitonin Receptor–Like Receptor in Uterine Leiomyoma: Endothelial Phenotype and Association with Microvascular Density