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View article: Obstetrical use of intravenous immunoglobulin: A single-centre retrospective study
Obstetrical use of intravenous immunoglobulin: A single-centre retrospective study Open
Findings highlight the need for optimized intravenous immunoglobulin use in obstetrics and future research to ensure safety, efficacy, and evidence-based guidance in clinical practice and policy.
View article: Optimizing emergency department care for people with bleeding disorders: A scoping review of barriers and interventions for improvement
Optimizing emergency department care for people with bleeding disorders: A scoping review of barriers and interventions for improvement Open
BACKGROUND People with bleeding disorders often require emergency department (ED) care due to increased risk of life-threatening spontaneous or traumatic bleeding events. Timely administration of hemostatic therapy is critical to reduce mo…
View article: Molecular Insights into Gastric Cancer: A Comparative Analysis of Asian and White Populations.
Molecular Insights into Gastric Cancer: A Comparative Analysis of Asian and White Populations. Open
Significant molecular differences exist in gastric cancer between Asian and White populations, showing the need for population-specific treatment strategies. These findings may inform personalized therapeutic approaches and contribute to t…
View article: Predictors of platelet count response following intravenous immunoglobulin use for maternal thrombocytopenia
Predictors of platelet count response following intravenous immunoglobulin use for maternal thrombocytopenia Open
IVIG effectively increases PLT counts in pregnant persons with severe thrombocytopenia, especially in those with a nadir PLT < 30 × 109/L, IPF < 16 %, or pre-IVIG PLT < 50 × 109/L. This study highlights the importance of careful patient se…
View article: Genomic testing for bleeding disorders (GT4BD): protocol for a randomised controlled trial evaluating the introduction of whole genome sequencing early in the diagnostic pathway for patients with inherited bleeding disorders as compared with standard of care
Genomic testing for bleeding disorders (GT4BD): protocol for a randomised controlled trial evaluating the introduction of whole genome sequencing early in the diagnostic pathway for patients with inherited bleeding disorders as compared with standard of care Open
Introduction The current diagnostic pathway for patients with a suspected inherited bleeding disorder is long, costly, resource intensive, emotionally draining for patients and often futile, as half of patients will remain without a diagno…
View article: Impact of clonal hematopoiesis of indeterminate potential on arterial atherothrombosis and venous thromboembolism: Protocol for a systematic review and meta-analysis.
Impact of clonal hematopoiesis of indeterminate potential on arterial atherothrombosis and venous thromboembolism: Protocol for a systematic review and meta-analysis. Open
This systematic review protocol was registered with the Internal Prospective Register of Systematic Reviews (PROSPERO, registration number CRD42024539923).
View article: Stakeholder perceptions and experiences of competency-based training with entrustable professional activities (SPECTRE): protocol of a systematic review and thematic synthesis of qualitative research
Stakeholder perceptions and experiences of competency-based training with entrustable professional activities (SPECTRE): protocol of a systematic review and thematic synthesis of qualitative research Open
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View article: Stakeholder Perceptions and Experiences of Competency-Based Training with Entrustable Professional Activities (SPECTRE): Protocol of a Systematic Review and Thematic Synthesis of Qualitative Research
Stakeholder Perceptions and Experiences of Competency-Based Training with Entrustable Professional Activities (SPECTRE): Protocol of a Systematic Review and Thematic Synthesis of Qualitative Research Open
Background: Competency-Based Medical Education (CBME) aims to align educational outcomes with the demands of modern healthcare. Entrustable Professional Activities (EPAs) serve as key tools for feedback and professional development within …
View article: Barriers and Facilitators for Diagnosing and Managing Iron Deficiency Anemia from Healthcare Professionals' Perspective in Alberta, Canada: A Qualitative Study
Barriers and Facilitators for Diagnosing and Managing Iron Deficiency Anemia from Healthcare Professionals' Perspective in Alberta, Canada: A Qualitative Study Open
Background: Anemia in reproductive-age women is a significant global public health issue. In Canada, despite a universal healthcare system, the prevalence of anemia among these women has risen over the past decade. Iron deficiency anemia (…
View article: From Theory to Therapy: Evaluating Canadian Hemophilia Treatment Centres' Readiness for Gene Therapy Implementation
From Theory to Therapy: Evaluating Canadian Hemophilia Treatment Centres' Readiness for Gene Therapy Implementation Open
Introduction: Gene therapies (GT) present a transformative promise for persons with hemophilia, potentially offering a long-term solution to improve patient care and experiences. However, in publicly funded systems, GT's promise will fall …
View article: Predictors of diagnostic delays and loss to follow-up in women with von Willebrand disease: a single-center retrospective cohort study
Predictors of diagnostic delays and loss to follow-up in women with von Willebrand disease: a single-center retrospective cohort study Open
Delayed diagnosis and loss to follow-up in VWD are common even in a specialized Hemophilia Treatment Centre. Such delays lead to more severe bleeding and increased gynecologic interventions. Prompt diagnosis is paramount for better patient…
View article: Rethinking patient feedback: A provocation for genuine integration in healthcare
Rethinking patient feedback: A provocation for genuine integration in healthcare Open
The authors challenge healthcare to radically embrace patient feedback, arguing it's the key to transforming care and education into genuinely patient‐centered practices.
View article: Comparing Classifications from Multiple Variant Annotation Software Solutions Using Real-World Next Generation Sequencing Data from Oncology Testing
Comparing Classifications from Multiple Variant Annotation Software Solutions Using Real-World Next Generation Sequencing Data from Oncology Testing Open
Variant annotation is an important step in deciphering the functional impact of genomic variants and their association with diseases. In this study, we analyzed 80 pan-cancer cases that underwent comprehensive genomic testing and compared …
View article: Management strategies in persons with inherited haemophilia requiring antithrombotic therapy: A scoping review
Management strategies in persons with inherited haemophilia requiring antithrombotic therapy: A scoping review Open
Background Thromboembolic events are increasingly reported in the aging haemophilia population. The purpose of this study was to understand current practices and identify knowledge and research gaps in the management of persons with haemop…
View article: Neuraxial Analgesia in Pregnant Individuals with Bleeding Disorders: A Comprehensive Examination of Obstetric Anesthesia Practices and Outcomes
Neuraxial Analgesia in Pregnant Individuals with Bleeding Disorders: A Comprehensive Examination of Obstetric Anesthesia Practices and Outcomes Open
Introduction: Neuraxial analgesia in obstetric anesthesia offers multiple advantages when compared with general anesthesia, including better pain relief and patient satisfaction, reduced opioid-related side effects, and decreased maternal …
View article: Predictors of Diagnostic Delays and Loss to Follow-up in Women with Von Willebrand Disease
Predictors of Diagnostic Delays and Loss to Follow-up in Women with Von Willebrand Disease Open
Background: Diagnostic and treatment delays in von Willebrand disease (vWD) disproportionately affect women. Such delays may lead to poor health outcomes from preventable bleeding complications related to menstruation, childbirth, and surg…
View article: Thrombin generation, bleeding and hemostasis in humans: Protocol for a scoping review of the literature
Thrombin generation, bleeding and hemostasis in humans: Protocol for a scoping review of the literature Open
Introduction Hemostasis and bleeding are difficult to measure. Thrombin generation assays (TGAs) can measure both procoagulant and anticoagulant contributions to coagulation. TGAs might prove useful for the study of bleeding disorders. The…
View article: PB0620 (Mis)Labeling Hemophilia Severity: Exploring the Illness Cognitions of Persons with Hemophilia
PB0620 (Mis)Labeling Hemophilia Severity: Exploring the Illness Cognitions of Persons with Hemophilia Open
Background: Since the publication of the 3rd edition of the World Federation of Hemophilia's (WFH) Guidelines for the Management of Hemophilia in August 2020, the WFH has been implementing a Living Guidelines Model (LGM) to ensure recommen…
View article: PB0686 Clinical Decisions and Factors Influencing the Management of Persons with Hemophilia Requiring Antithrombotic Therapy: A Qualitative Study
PB0686 Clinical Decisions and Factors Influencing the Management of Persons with Hemophilia Requiring Antithrombotic Therapy: A Qualitative Study Open
Background:The global population is growing; those over 65 years are the leading demographic.People with bleeding disorders (PWBD) are living longer than ever and experiencing diseases of ageing with specific management challenges.Little h…
View article: Human granulocytic anaplasmosis complicated by hemophagocytic syndrome and coinfection
Human granulocytic anaplasmosis complicated by hemophagocytic syndrome and coinfection Open
KEY POINTS A 74-year-old man with end-stage renal disease was admitted to hospital in the spring after an episode of syncope that occurred during a hemodialysis session 1 day after he returned from his cottage in eastern Ontario. Within 24…
View article: New onset of acute heavy menstrual bleeding in a 34-year-old woman
New onset of acute heavy menstrual bleeding in a 34-year-old woman Open
A 34-year-old woman presented to the emergency department with a 1-day history of heavy menstrual bleeding. She described needing to use thick pads or diapers that required changing hourly because of the heavy flow of blood. One month prev…