Roy Moscona
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View article: Newly designed amplicons-based method for near-full-length genome (NFLG) sequencing of HIV-1 group M recombinant forms
Newly designed amplicons-based method for near-full-length genome (NFLG) sequencing of HIV-1 group M recombinant forms Open
Background Over the years the spread of HIV-1 across the globe resulted in the creation of multiple subtypes and new recombinant forms (RFs). While the pol gene region of the HIV-1 genome is used for resistance mutations analysis and initi…
View article: Immune Clustering Reveals Molecularly Distinct Subtypes of Lung Adenocarcinoma
Immune Clustering Reveals Molecularly Distinct Subtypes of Lung Adenocarcinoma Open
Background/objectives: Lung adenocarcinoma, the most prevalent type of non-small cell lung cancer, consists of two driver mutations in KRAS or EGFR. These mutations are generally mutually exclusive and biologically and clinically different…
View article: HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)
HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND) Open
HIV-associated neurocognitive disorders (HAND) cause significant dysfunction among people living with HIV. Microglia are the primary immune cells of the central nervous system and are readily infected by HIV. Microglia are thought to contr…
View article: Novel Amplicons based Method for Near-Full-Length Genome (NFLG) Sequencing of HIV-1 Group M Recombinant Forms
Novel Amplicons based Method for Near-Full-Length Genome (NFLG) Sequencing of HIV-1 Group M Recombinant Forms Open
Over the years the spread of HIV-1 across the globe resulted in the creation of multiple subtypes and new recombinant forms (RFs). While the pol gene region of the HIV-1 genome is used for resistance mutations analysis and initial detectio…
View article: <scp>BORIS</scp> / <scp>CTCFL</scp> ‐mediated chromatin accessibility alterations promote a pro‐invasive transcriptional signature in melanoma cells
<span>BORIS</span> / <span>CTCFL</span> ‐mediated chromatin accessibility alterations promote a pro‐invasive transcriptional signature in melanoma cells Open
Melanoma is the deadliest form of skin cancer, due to its tendency to metastasize early. Brother of regulator of imprinted sites (BORIS), also known as CCCTC binding factor‐like (CTCFL), is a transcription regulator that becomes ectopicall…
View article: Immune clustering reveals molecularly distinct subtypes of lung adenocarcinoma
Immune clustering reveals molecularly distinct subtypes of lung adenocarcinoma Open
Lung adenocarcinoma, the most prevalent type of non-small cell lung cancer, consists of two driver mutations in KRAS or EGFR. In general, these mutations are mutually exclusive, and biologically and clinically different. In this study, we …
View article: BORIS/CTCFL-mediated chromatin accessibility alterations promote a pro-invasive transcriptional signature in melanoma cells
BORIS/CTCFL-mediated chromatin accessibility alterations promote a pro-invasive transcriptional signature in melanoma cells Open
Melanoma is the deadliest form of skin cancer, due to its tendency to metastasize early. Brother of Regulator of Imprinted Sites (BORIS), also known as CCCTC binding factor-Like (CTCFL), is a transcription regulator that becomes ectopicall…
View article: BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cell lines
BORIS/CTCFL promotes a switch from a proliferative towards an invasive phenotype in melanoma cell lines Open
Melanoma is among the most aggressive cancers due to its tendency to metastasize early. Phenotype switching between a proliferative and an invasive state has been suggested as a critical process for metastasis. The mechanisms that regulate…
View article: A17 Transmitted drug-resistant mutations among recently infected HIV-1 patients in Israel, 2000–2014
A17 Transmitted drug-resistant mutations among recently infected HIV-1 patients in Israel, 2000–2014 Open
cent) were successfully genotyped: HIV-1 subtype C was the most prevalent (97 per cent), followed by subtype A1 (1.2 per cent), mosaic recombinant forms (1.2 per cent), subtype G (0.5 per cent), and subtype D (0.2 per cent).Over 60 per cen…
View article: Comparison between next‐generation and Sanger‐based sequencing for the detection of transmitted drug‐resistance mutations among recently infected HIV‐1 patients in Israel, 2000–2014
Comparison between next‐generation and Sanger‐based sequencing for the detection of transmitted drug‐resistance mutations among recently infected HIV‐1 patients in Israel, 2000–2014 Open
Introduction : Transmitted drug‐resistance mutations (TDRM) may hamper successful anti‐HIV‐1 therapy and impact future control of the HIV‐1 epidemic. Recently infected, therapy‐naïve individuals are best suited for surveillance of such TDR…