Explanipedia

171. Predictors of Globe Injuries in Over 340,000 Facial Fracture Patients: A National Trauma Data Bank Study Open

Michael Edgar, Han Jiang, Megan M. Perez, Daniel Paku, Akriti Choudhary , et al. · 2025

Astigmatism Management in Modern Cataract Surgery Open

Royce Park, Ahmad A. Aref · 2024

Astigmatism management is a frequently encountered challenge in the world of modern cataract surgery. This review article investigates the importance of astigmatic correction and seeks to uncover the critical components of preoperative eva…

Bilateral Cavernous Sinus Thrombosis in Presumed COVID-19 Infection Open

Stephen LoBue, Royce Park, Richard Giovane, John DeLury, Nickisa Hodgson · 2022

Cavernous sinus thrombosis (CST) is a rare life-threatening condition where a blood clot develops within the cavernous sinus secondary to various etiologies, ranging from infection to aseptic causes (e.g., trauma or surgery). The dural sin…

A review of surgical management of progressive myogenic ptosis Open

Royce Park, Sruti S. Akella, Vinay K. Aakalu · 2022

Surgical correction of myogenic ptosis is a sophisticated endeavor, as the disease is progressive and the post-operative course is prone to significant complications. We sought to review the literature for repair techniques in different ty…

Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains Open

Kiran Girdhar, Gabriel E. Hoffman, Jaroslav Bendl, Samir Rahman, Pengfei Dong , et al. · 2022

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders Open

Benxia Hu, Hyejung Won, Won Mah, Royce Park, Bibi Kassim , et al. · 2021

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders Open

Benxia Hu, Hyejung Won, Won Mah, Royce Park, Bibi Kassim , et al. · 2021

Cellular heterogeneity in the human brain obscures the identification of robust cellular regulatory networks, which is necessary to understand the function of non-coding elements and the impact of non-coding genetic variation. Here we inte…

Acetylated Chromatin Domains Link Chromosomal Organization to Cell- and Circuit-level Dysfunction in Schizophrenia and Bipolar Disorder Open

Kiran Girdhar, Gabriel E. Hoffman, Jaroslav Bendl, Samir Rahman, Pengfei Dong , et al. · 2021

To explore modular organization of chromosomes in schizophrenia (SCZ) and bipolar disorder (BD), we applied ‘population-scale’ correlational structuring of 739 histone H3-lysine 27 acetylation and H3-lysine 4 trimethylation profiles, gener…

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions Open

Solveig K. Sieberts, Thanneer M. Perumal, Minerva M. Carrasquillo, Mariet Allen, Joseph S. Reddy , et al. · 2020

Functional annotation of rare structural variation in the human brain Open

Lide Han, Xuefang Zhao, Mary Lauren Benton, Thanneer M. Perumal, Ryan L. Collins , et al. · 2020

Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disorders Open

Benxia Hu, Hyejung Won, Won Mah, Royce Park, Bibi Kassim , et al. · 2020

Cellular heterogeneity in the human brain obscures the identification of robust cellular regulatory networks. Here we integrated genome-wide chromosome conformation in purified neurons and glia with transcriptomic and enhancer profiles to …

Revealing the brain's molecular architecture Open

Allison E. Ashley‐Koch, Gregory E. Crawford, Melanie E. Garrett, Lingyun Song, Alexias Safi , et al. · 2018

Genetic variants may lead to disease, denoted here by a dimmed letter representing a nucleotide. The PsychENCODE Consortium presents research to link the effects of genetic variation to gene expression in the brain.

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder Open

Michael J. Gandal, Pan Zhang, Evi Hadjimichael, Rebecca L. Walker, Chao Chen , et al. · 2018

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags behind other fields of medicine. The diagnosis and study of thes…

Comprehensive functional genomic resource and integrative model for the human brain Open

Daifeng Wang, Shuang Liu, Jonathan Warrell, Hyejung Won, Xu Shi , et al. · 2018

INTRODUCTION Strong genetic associations have been found for a number of psychiatric disorders. However, understanding the underlying molecular mechanisms remains challenging. RATIONALE To address this challenge, the PsychENCODE Consortium…

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome Open

Kiran Girdhar, Gabriel E. Hoffman, Yan Jiang, Leanne Brown, Marija Kundaković , et al. · 2018

The epigenomics of schizophrenia, in the mouse Open

Behnam Javidfar, Royce Park, Bibi Kassim, Lucy Bicks, Schahram Akbarian · 2017

Large‐scale consortia including the Psychiatric Genomics Consortium, the Common Minds Consortium, BrainSeq and PsychENCODE, and many other studies taken together provide increasingly detailed insights into the genetic and epigenetic risk a…

Practical Guidelines for High-Resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue Open

Marija Kundaković, Yan Jiang, David H. Kavanagh, Aslihan Dincer, Leanne Brown , et al. · 2016

NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure Open

Tobias Halene, Alexey Kozlenkov, Yan Jiang, Amanda Mitchell, Behnam Javidfar , et al. · 2016

Logos and Inserts can Reduce Survey Return Rates: An Experiment in California Open

Matt Jans, Royce Park, John Rauch, David Grant, Sherman Edwards · 2015

Survey methodologists seek techniques that make the mail they send more likely to be opened, completed, and returned than missed, ignored, or thrown away. Traditional design wisdom recommends against using color and logos, which can make t…

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