Royston Goodacre
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View article: Synthesis of <scp>C8</scp> ‐Vinyl Chlorophylls <scp> <i>d</i> </scp> and <scp> <i>f</i> </scp> Impairs Far‐Red Light Photoacclimation and Growth Under Far‐Red Light
Synthesis of <span>C8</span> ‐Vinyl Chlorophylls <span> <i>d</i> </span> and <span> <i>f</i> </span> Impairs Far‐Red Light Photoacclimation and Growth Under Far‐Red Light Open
The inducible biosynthesis of chlorophylls d and f enables a subset of specialised cyanobacteria to perform oxygenic photosynthesis under far‐red light—in the absence of visible wavelengths—via a process termed far‐red light photoacclimati…
View article: Reprogramme the E. coli metabolism by engineering a functional carbon-fixation pathway
Reprogramme the E. coli metabolism by engineering a functional carbon-fixation pathway Open
Background Rising atmospheric CO₂ levels and their impact on climate change have intensified the need for innovative carbon capture and fixation strategies. The Calvin-Benson-Bassham (CBB) cycle, a central metabolic pathway in all photoaut…
View article: Combining clinical chemistry with metabolomics for metabolic phenotyping at population levels
Combining clinical chemistry with metabolomics for metabolic phenotyping at population levels Open
Introduction Untargeted metabolic phenotyping (metabolomics/metabonomics), also known as metabotyping, has been shown to be able to discriminate reliably between different physiological or clinical conditions. However, we believe that stan…
View article: Application of Rapid Evaporative Ionization Mass Spectrometry (REIMS) to Identify Antimicrobial Resistance in Uropathogenic <i>Escherichia coli</i> (UPEC) Isolates via Deuterium Isotope Probing
Application of Rapid Evaporative Ionization Mass Spectrometry (REIMS) to Identify Antimicrobial Resistance in Uropathogenic <i>Escherichia coli</i> (UPEC) Isolates via Deuterium Isotope Probing Open
Antimicrobial resistance (AMR) continues to pose a significant threat to global health, undermining advances in modern medicine and increasing mortality from previously treatable infections. Rapid and accurate antimicrobial susceptibility …
View article: Mgl2<sup>+</sup> cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose
Mgl2<sup>+</sup> cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose Open
Fungal spores are a major cause of severe asthmatic disease. However, the precise events that cause individuals to become sensitised to spores are poorly understood. Mgl2 + type 2 conventional dendritic cells (Mgl2 + cDC2s) are critical in…
View article: Raman on the palm: handheld Raman spectroscopy for enhanced traceability of palm oil
Raman on the palm: handheld Raman spectroscopy for enhanced traceability of palm oil Open
Determining the geographic origin of palm oil in West Africa is vital for economic, environmental, and health reasons. It enhances traceability, protects local farmers, supports conservation by monitoring deforestation, and reduces food fr…
View article: Synthesis of C8-vinyl chlorophylls <i>d</i> and <i>f</i> impairs far-red light photoacclimation and growth under far-red light
Synthesis of C8-vinyl chlorophylls <i>d</i> and <i>f</i> impairs far-red light photoacclimation and growth under far-red light Open
The inducible biosynthesis of chlorophylls d and f enables a subset of specialised cyanobacteria to perform oxygenic photosynthesis under far-red light—in the absence of visible wavelengths—via a process termed far-red light photoacclimati…
View article: Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China
Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China Open
Our results indicate that higher soil arsenic exposure is associated with an increased risk of pain in specific body regions. This study is the first examining the associations between multiple heavy metals in surface soil and the risks of…
View article: Raman on the Palm: Handheld Raman Spectroscopy for Enhanced Traceability of Palm Oil
Raman on the Palm: Handheld Raman Spectroscopy for Enhanced Traceability of Palm Oil Open
Determining the geographic origin of palm oil in West Africa is vital for economic, environmental, and health reasons. It enhances traceability, protects local farmers, supports conservation by monitoring deforestation, and reduces food fr…
View article: SERS-based lateral flow immunoassay utilising plasmonic nanoparticle clusters for ultra-sensitive detection of salivary cortisol
SERS-based lateral flow immunoassay utilising plasmonic nanoparticle clusters for ultra-sensitive detection of salivary cortisol Open
We report the first SERS-based LFIA for salivary cortisol, achieving 0.014 pg mL −1 sensitivity—650× better than conventional LFIAs— via size-controlled Au clusters and dual-line Raman mapping, with strong correlation to UPLC-MS/MS.
View article: Assessing Emissions of Biogenic Volatile Organic Compounds and Their Correlation with Abiotic Factors in an Atlantic Forest Reserve Using Supervised Learning Methods
Assessing Emissions of Biogenic Volatile Organic Compounds and Their Correlation with Abiotic Factors in an Atlantic Forest Reserve Using Supervised Learning Methods Open
This study investigates the emissions of biogenic volatile organic compounds (BVOCs) in an Atlantic Forest fragment and examines their correlation with abiotic factors. Despite its rich biodiversity, the Atlantic Forest remains under threa…
View article: Metabolic response of Klebsiella oxytoca to ciprofloxacin exposure: a metabolomics approach
Metabolic response of Klebsiella oxytoca to ciprofloxacin exposure: a metabolomics approach Open
Introduction Rapid detection and identification of pathogens and antimicrobial susceptibility is essential for guiding appropriate antimicrobial therapy and reducing morbidity and mortality associated with sepsis. Objectives The metabolic …
View article: A Millimeter-Scale Change in Leaf Litter Placement Within Soil-Water Interfaces Alters Carbon Dioxide and Methane Emission
A Millimeter-Scale Change in Leaf Litter Placement Within Soil-Water Interfaces Alters Carbon Dioxide and Methane Emission Open
Flooded soils play a critical role in global carbon cycling, serving as significant reservoirs of soil organic carbon and sources of carbon emissions. Leaf litter, particularly from local vegetation, is a major contributor to soil organic …
View article: Efficient Carbon Dioxide and Methane Flux Monitoring in Soil Microcosms Using an Automated Chamber with a Cartesian Robot
Efficient Carbon Dioxide and Methane Flux Monitoring in Soil Microcosms Using an Automated Chamber with a Cartesian Robot Open
1.Accurate measurement of carbon dioxide (CO₂) and methane (CH₄) emissions from soil is crucial for understanding carbon dynamics and developing strategies to mitigate climate change. Traditional chamber techniques and soil incubation expe…
View article: Application of infrared spectroscopy to study carbon-deuterium kinetics and isotopic spectral shifts at the single-cell level
Application of infrared spectroscopy to study carbon-deuterium kinetics and isotopic spectral shifts at the single-cell level Open
Microbial communities play crucial roles in shaping natural ecosystems, impacting human well-being, and driving advancements in industrial biotechnology. However, associating specific metabolic functions with bacteria proves challenging du…
View article: Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy Open
Introduction Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflamm…
View article: Trends in Antimicrobial Resistance of Uropathogens Isolated from Urinary Tract Infections in a Tertiary Care Hospital in Dhaka, Bangladesh
Trends in Antimicrobial Resistance of Uropathogens Isolated from Urinary Tract Infections in a Tertiary Care Hospital in Dhaka, Bangladesh Open
Background/Objectives: Urinary tract infection (UTI) is a prevalent microbial infection in medical practise, leading to significant patient morbidity and increased treatment costs, particularly in developing countries. This retrospective s…
View article: Rapid Classification and Differentiation of Sepsis-Related Pathogens Using FT-IR Spectroscopy
Rapid Classification and Differentiation of Sepsis-Related Pathogens Using FT-IR Spectroscopy Open
Sepsis is a life-threatening condition arising from a dysregulated host immune response to infection, leading to a substantial global health burden. The accurate identification of bacterial pathogens in sepsis is essential for guiding effe…
View article: An optical photothermal infrared investigation of lymph nodal metastases of oral squamous cell carcinoma
An optical photothermal infrared investigation of lymph nodal metastases of oral squamous cell carcinoma Open
In this study, optical photothermal infrared (O-PTIR) spectroscopy combined with machine learning algorithms were used to evaluate 46 tissue cores of surgically resected cervical lymph nodes, some of which harboured oral squamous cell carc…
View article: Bacterial discrimination by Fourier transform infrared spectroscopy, MALDI-mass spectrometry and whole-genome sequencing
Bacterial discrimination by Fourier transform infrared spectroscopy, MALDI-mass spectrometry and whole-genome sequencing Open
Aim: Proof-of-concept study, highlighting the clinical diagnostic ability of FT-IR compared with MALDI-TOF MS, combined with WGS. Materials & methods: 104 pathogenic isolates of Neisseria meningitidis, Streptococcus pneumoniae, Streptococc…