Roz Laing
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View article: Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus
Analyses of emerging macrocyclic lactone resistance: Speed and signature of ivermectin and moxidectin selection and evidence of a shared genetic locus Open
Subtherapeutic treatment or ‘underdosing’ is considered a common problem in the control of parasitic helminths of animals and people and can hasten the emergence of anthelmintic resistance. Increasing reliance on the long-acting macrocycli…
View article: Characterising anthelmintic resistance against benzimidazoles and macrocyclic lactones in gastrointestinal nematode populations of dairy cattle
Characterising anthelmintic resistance against benzimidazoles and macrocyclic lactones in gastrointestinal nematode populations of dairy cattle Open
Anthelmintic resistance in gastrointestinal nematode populations is endemic across all grazing livestock production systems, particularly in small ruminants, but also in cattle. In this study resistance in Cooperia oncophora and Ostertagia…
View article: Seasonal patterns of faecal egg counts and gastrointestinal nematode species composition in Scottish dairy calves
Seasonal patterns of faecal egg counts and gastrointestinal nematode species composition in Scottish dairy calves Open
View article: The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro
The parasitic nematode Haemonchus contortus lacks molybdenum cofactor synthesis, leading to sulphite sensitivity and lethality in vitro Open
Sulphite oxidase has an essential role in detoxifying environmental and endogenously generated sulphite into sulphate and requires the molybdenum cofactor (Moco) to function. Until recently it was believed that the synthesis pathway for Mo…
View article: Development of a loop-mediated isothermal amplification detection assay for Dictyocaulus viviparus (Bloch, 1782) lungworm: DviLAMP
Development of a loop-mediated isothermal amplification detection assay for Dictyocaulus viviparus (Bloch, 1782) lungworm: DviLAMP Open
The bovine lungworm, Dictyocaulus viviparus (Bloch, 1782), is highly pathogenic and disease outbreaks can be difficult to predict and manage. Rapid and accurate diagnosis is vital, but without a sensitive diagnostic test this remains chall…
View article: Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta
Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta Open
The parasitic nematode Teladorsagia circumcincta is one of the most important pathogens of sheep and goat farming in temperate climates worldwide and can rapidly evolve resistance to drugs used to control it. To understand the genetics of …
View article: Inefficacy of ivermectin and moxidectin treatments against <i>Dictyocaulus viviparus</i> in dairy calves
Inefficacy of ivermectin and moxidectin treatments against <i>Dictyocaulus viviparus</i> in dairy calves Open
Background The bovine lungworm Dictyocaulus viviparus negatively impacts bovine health and leads to substantial economic losses. Lungworm infections can be difficult to manage due to the unpredictable and severe nature of clinical outbreak…
View article: Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus
Functional validation of novel levamisole resistance marker S168T in Haemonchus contortus Open
View article: Real-time single-base specific detection of the Haemonchus contortus S168T variant associated with levamisole resistance using loop-primer endonuclease cleavage loop-mediated isothermal amplification
Real-time single-base specific detection of the Haemonchus contortus S168T variant associated with levamisole resistance using loop-primer endonuclease cleavage loop-mediated isothermal amplification Open
Haemonchus contortus is a parasitic haematophagous nematode that primarily affects small ruminants and causes significant economic loss to the global livestock industry. Treatment of haemonchosis typically relies on broad-spectrum anthelmi…
View article: A mixed amplicon metabarcoding and sequencing approach for surveillance of drug resistance to levamisole and benzimidazole in Haemonchus spp.
A mixed amplicon metabarcoding and sequencing approach for surveillance of drug resistance to levamisole and benzimidazole in Haemonchus spp. Open
Anthelmintic-resistant parasitic nematodes present a significant threat to sustainable livestock production worldwide. The ability to detect the emergence of anthelmintic resistance at an early stage, and therefore determine which drugs re…
View article: A mixed amplicon metabarcoding and sequencing approach for surveillance of drug resistance to levamisole and benzimidazole in<i>Haemonchus</i>spp
A mixed amplicon metabarcoding and sequencing approach for surveillance of drug resistance to levamisole and benzimidazole in<i>Haemonchus</i>spp Open
Anthelmintic resistant parasitic nematodes present a significant threat to sustainable livestock production worldwide. The ability to detect the emergence of anthelmintic resistance at an early stage, and therefore determine which drugs re…
View article: New technologies to study helminth development and host-parasite interactions
New technologies to study helminth development and host-parasite interactions Open
How parasites develop and survive, and how they stimulate or modulate host immune responses are important in understanding disease pathology and for the design of new control strategies. Microarray analysis and bulk RNA sequencing have pro…
View article: Genomic landscape of drug response reveals mediators of anthelmintic resistance
Genomic landscape of drug response reveals mediators of anthelmintic resistance Open
View article: Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus
Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus Open
Haemonchus contortus is a haematophagous parasitic nematode that infects small ruminants and causes significant animal health concerns and economic losses within the livestock industry on a global scale. Treatment primarily depends on broa…
View article: Allele specific PCR for a major marker of levamisole resistance in <i>Haemonchus contortus</i>
Allele specific PCR for a major marker of levamisole resistance in <i>Haemonchus contortus</i> Open
Haemonchus contortus is a haematophagous parasitic nematode that infects small ruminants and causes significant animal health concerns and economic losses within the livestock industry on a global scale. Treatment primarily depends on broa…
View article: Genomic signatures of selection associated with benzimidazole drug treatments in <i>Haemonchus contortus</i> field populations
Genomic signatures of selection associated with benzimidazole drug treatments in <i>Haemonchus contortus</i> field populations Open
Genome-wide methods offer a powerful approach to detect signatures of drug selection in parasite populations in the field. However, their application to parasitic nematodes has been limited because of both a lack of suitable reference geno…
View article: Genomic landscape of drug response reveals novel mediators of anthelmintic resistance
Genomic landscape of drug response reveals novel mediators of anthelmintic resistance Open
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is key to improving the efficacy and sustainability of parasite control. Here, we use a genetic cross in a natural host-parasite system to simultaneousl…
View article: Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode
Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode Open
The antiparasitic drug ivermectin plays an essential role in human and animal health globally. However, ivermectin resistance is widespread in veterinary helminths and there are growing concerns of sub-optimal responses to treatment in rel…
View article: Extensive genomic and transcriptomic variation defines the chromosome-scale assembly of<i>Haemonchus contortus</i>, a model gastrointestinal worm
Extensive genomic and transcriptomic variation defines the chromosome-scale assembly of<i>Haemonchus contortus</i>, a model gastrointestinal worm Open
Background Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants, and has become the key nematode model for studying anthelmintic resistance and other parasite-specific trait…
View article: Small RNAs in parasitic nematodes – forms and functions
Small RNAs in parasitic nematodes – forms and functions Open
Small RNAs are important regulators of gene expression. They were first identified in Caenorhabditis elegans , but it is now apparent that the main small RNA silencing pathways are functionally conserved across diverse organisms. Availabil…
View article: Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta
Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta Open
Recent reports of monepantel (MPTL) resistance in UK field isolates of Teladorsagia circumcincta has highlighted the need for a better understanding of the mechanism of MPTL-resistance in order to preserve its anthelmintic efficacy in this…
View article: Refugia and anthelmintic resistance: Concepts and challenges
Refugia and anthelmintic resistance: Concepts and challenges Open
View article: Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing
Evaluation of DNA extraction methods on individual helminth egg and larval stages for whole genome sequencing Open
Whole genome sequencing is being rapidly applied to the study of helminth genomes, including de novo genome assembly, population genetics, and diagnostic applications. Although late-stage juvenile and adult parasites typically produce suff…
View article: Additional file 12: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus
Additional file 12: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus Open
Table S1. Sample sequencing data archived at European Nucleotide Archive repository under the study accession PRJEB2353. (XLSX 12 kb)
View article: Hidden in plain sight - Multiple resistant species within a strongyle community
Hidden in plain sight - Multiple resistant species within a strongyle community Open
Ovine parasitic gastroenteritis is a complex disease routinely treated using anthelmintics. Although many different strongyle species may contribute to parasitic gastroenteritis, not all are equally pathogenic: in temperate regions, the pr…
View article: Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, <i>Haemonchus contortus</i>
Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, <i>Haemonchus contortus</i> Open
Background Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infect livestock and com…
View article: Transcriptomic profiling of nematode parasites surviving vaccine exposure
Transcriptomic profiling of nematode parasites surviving vaccine exposure Open
View article: A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry
A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry Open
The parasitic nematode Haemonchus contortus is an economically and clinically important pathogen of small ruminants, and a model system for understanding the mechanisms and evolution of traits such as anthelmintic resistance. Anthelmintic …
View article: Ivermectin – Old Drug, New Tricks?
Ivermectin – Old Drug, New Tricks? Open