Roberto Silva Costa
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View article: Relato de tumor estromal gastrointestinal (GIST) cecal em cadela idosa: integração clínica, cirúrgica e laboratorial
Relato de tumor estromal gastrointestinal (GIST) cecal em cadela idosa: integração clínica, cirúrgica e laboratorial Open
O Tumor Estromal Gastrointestinal (GIST) é neoplasia mesenquimal incomum em cães, originada das células intersticiais de Cajal, com apresentação clínica inespecífica. Relata-se o caso de uma cadela SRD, de oito anos, atendida inicialmente …
View article: Cutaneous T-cell lymphoma: is it possible to monitor progression beyond skin lesions? Case report
Cutaneous T-cell lymphoma: is it possible to monitor progression beyond skin lesions? Case report Open
Canine cutaneous T-cell lymphoma (CTCL) is an aggressive neoplasm that is challenging to manage and is often associated with a guarded to poor prognosis. This case report aimed to describe the clinical and therapeutic aspects of a 14-year-…
View article: OPHTHALMIC INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS IS ASSOCIATED WITH INTERFERON-ALPHA GENE SIGNATURE: A CROSS-SECTIONAL STUDY
OPHTHALMIC INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS IS ASSOCIATED WITH INTERFERON-ALPHA GENE SIGNATURE: A CROSS-SECTIONAL STUDY Open
PV102 / #625 Poster Topic: AS12 - Genetics, Epigenetics, Transcriptomics Background/Purpose Interferon Pathways studies have highlighted the role of type I interferons, especially interferon-alpha (IFN-α), in driving inflammatory pathways …
View article: DOES SLEDAI-2K REFLECT THE INTERFERON-ALPHA GENE SIGNATURE IN SYSTEMIC LUPUS ERYTHEMATOSUS? PRELIMINARY RESULTS FROM A COHORT
DOES SLEDAI-2K REFLECT THE INTERFERON-ALPHA GENE SIGNATURE IN SYSTEMIC LUPUS ERYTHEMATOSUS? PRELIMINARY RESULTS FROM A COHORT Open
PV103 / #629 Poster Topic: AS12 - Genetics, Epigenetics, Transcriptomics Background/Purpose Interferon pathways studies have highlighted the role of type I interferons, especially interferon-alpha (IFN-α), in driving inflammatory pathways …
View article: Correction: Mortality risk score for patients with Chagas cardiomyopathy and pacemaker
Correction: Mortality risk score for patients with Chagas cardiomyopathy and pacemaker Open
[This corrects the article DOI: 10.1371/journal.pntd.0012114.].
View article: Amiodarone or Implantable Cardioverter-Defibrillator in Chagas Cardiomyopathy
Amiodarone or Implantable Cardioverter-Defibrillator in Chagas Cardiomyopathy Open
Importance Over 10 000 people with Chagas disease experience sudden cardiac death (SCD) annually, mostly caused by ventricular fibrillation. Amiodarone hydrochloride and the implantable cardioverter-defibrillator (ICD) have been empiricall…
View article: TRAUMATISMO CRANIOENCEFÁLICO (TCE) COM EDEMA CEREBRAL EM UM CÃO – RELATO DE CASO
TRAUMATISMO CRANIOENCEFÁLICO (TCE) COM EDEMA CEREBRAL EM UM CÃO – RELATO DE CASO Open
A Universidade Federal do Norte do Tocantins é uma Instituição de ensino Superior considerada novíssima, pois foi fundada em 2018, tem como objetivo formar profissionais de excelência, tendo como sustentação o tripé: ensino, pesquisa e ext…
View article: Vitamin D deficiency contributes to the diabetic kidney disease progression via increase ZEB1/ZEB2 expressions
Vitamin D deficiency contributes to the diabetic kidney disease progression via increase ZEB1/ZEB2 expressions Open
View article: Isolated massive histiocytes renal interstitial infiltration: a case report of an unexpected cause of acute kidney injury in a kidney transplant recipient
Isolated massive histiocytes renal interstitial infiltration: a case report of an unexpected cause of acute kidney injury in a kidney transplant recipient Open
Background Acute kidney injury is a frequent cause of hospital readmission in kidney transplant recipients (KTR), usually associated with infections and graft rejection. Herein, we report a case of an unusual cause of acute kidney injury i…
View article: Vitamin D deficiency contributes to the diabetic kidney disease progression via increased ZEB1/ZEB2 expressions
Vitamin D deficiency contributes to the diabetic kidney disease progression via increased ZEB1/ZEB2 expressions Open
Background Diabetic kidney disease (DKD) remains one of the main causes of end-stage renal disease (ESRD) and mortality in diabetic patients worldwide. Vitamin D deficiency (VitDD) is one of the main consequences of different chronic kidne…
View article: Calcitriol Reduces the Inflammation, Endothelial Damage and Oxidative Stress in AKI Caused by Cisplatin
Calcitriol Reduces the Inflammation, Endothelial Damage and Oxidative Stress in AKI Caused by Cisplatin Open
Cisplatin treatment is one of the most commonly used treatments for patients with cancer. However, thirty percent of patients treated with cisplatin develop acute kidney injury (AKI). Several studies have demonstrated the effect of bioacti…
View article: Paricalcitol Improves the Angiopoietin/Tie-2 and VEGF/VEGFR2 Signaling Pathways in Adriamycin-Induced Nephropathy
Paricalcitol Improves the Angiopoietin/Tie-2 and VEGF/VEGFR2 Signaling Pathways in Adriamycin-Induced Nephropathy Open
Renal endothelial cell (EC) injury and microvascular dysfunction contribute to chronic kidney disease (CKD). In recent years, increasing evidence has suggested that EC undergoes an endothelial-to-mesenchymal transition (EndoMT), which migh…
View article: Lipoprotein glomerulopathy associated with the Osaka/Kurashiki APOE variant: two cases identified in Latin America
Lipoprotein glomerulopathy associated with the Osaka/Kurashiki APOE variant: two cases identified in Latin America Open
Background Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant disease caused by mutations in APOE , the gene which encodes apolipoprotein E. LPG mainly affects Asian individuals, however occasional cases have also been described…
View article: The Prevalence of Nondiabetic Renal Diseases in Patients with Diabetes Mellitus in the University Hospital of Ribeirão Preto, São Paulo
The Prevalence of Nondiabetic Renal Diseases in Patients with Diabetes Mellitus in the University Hospital of Ribeirão Preto, São Paulo Open
Objective . To evaluate the prevalence of nondiabetic renal diseases (NDRDs) in renal biopsies of patients with diabetes mellitus (DM) in the University Hospital of Ribeirão Preto, São Paulo. Research Design and Methods . We conducted a re…
View article: Effect of Calcitriol on the Renal Microvasculature Differentiation Disturbances Induced by AT1 Blockade During Nephrogenesis in Rats
Effect of Calcitriol on the Renal Microvasculature Differentiation Disturbances Induced by AT1 Blockade During Nephrogenesis in Rats Open
Alterations in the renal vasculature during fetal programming can cause disturbances in renal structure and function that persist into adulthood. Calcitriol can affect cellular differentiation and proliferation, and promote endothelial cel…
View article: Imbalance of Pro- and Anti-Angiogenic Factors Due to Maternal Vitamin D Deficiency Causes Renal Microvasculature Alterations Affecting the Adult Kidney Function
Imbalance of Pro- and Anti-Angiogenic Factors Due to Maternal Vitamin D Deficiency Causes Renal Microvasculature Alterations Affecting the Adult Kidney Function Open
Vitamin D (Vit.D) is involved in cellular proliferation and differentiation and regulation of the renin gene, which are important aspects of nephrogenesis and quiescence of renal health in adulthood. This study evaluated the angiogenic mec…
View article: Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats
Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats Open
Glycerol injection in rats can lead to rhabdomyolysis, with the release of the intracellular muscle content to the extracellular compartment and acute kidney injury (AKI). Oxidative stress and the inflammatory processes contribute to the d…
View article: Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report
Vitamin C-induced oxalate nephropathy in a renal transplant patient related to excessive ingestion of cashew pseudofruit (Anacardium occidentale L.): a case report Open
This pseudofruit is rich in ascorbic acid (vitamin C) and poor in oxalate. Urinary oxalate excretion begins to increase when amounts of ascorbic acid above bodily requirements are ingested, and may provoke acute oxalate nephropathy. The pa…
View article: Cytomegalovirus-Associated Glomerulonephritis in a Kidney Transplant Recipient
Cytomegalovirus-Associated Glomerulonephritis in a Kidney Transplant Recipient Open
View article: Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice
Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice Open
Chemerin, acting through its receptor ChemR23, is an adipokine associated with inflammatory response, glucose and lipid metabolism and vascular function. Although this adipokine has been associated with the development and progression of k…
View article: Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats
Previous Exercise Effects in Cisplatin-Induced Renal Lesions in Rats Open
Background/Aims: Physical training has beneficial effects on endothelial function and can influence the regeneration of the endothelial cell. We investigated the effect of physical training on cisplatin (CP)-induced acute kid…
View article: Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation Open
View article: Adenovirus pyelonephritis in the late posttransplant period
Adenovirus pyelonephritis in the late posttransplant period Open
View article: Effects of previous physical training on adriamycin nephropathy and its relationship with endothelial lesions and angiogenesis in the renal cortex
Effects of previous physical training on adriamycin nephropathy and its relationship with endothelial lesions and angiogenesis in the renal cortex Open