Yan Cui
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View article: Maternal asthma control, context, and timing: Refining perinatal risk
Maternal asthma control, context, and timing: Refining perinatal risk Open
View article: Mechanisms underlying the estradiol mediated protection of yak oviduct epithelial cells against ER-Ca2+ imbalance
Mechanisms underlying the estradiol mediated protection of yak oviduct epithelial cells against ER-Ca2+ imbalance Open
Our research results indicate that E2 protects YOECs under ER-Ca2+ imbalance by increasing the protein expression of IP3R3 serine 927, highlighting the close relationship between protein expression and phosphorylation…
View article: Aberrant dynamics of the default mode network activity in patients with obsessive-compulsive disorder
Aberrant dynamics of the default mode network activity in patients with obsessive-compulsive disorder Open
View article: Dexamethasone Intravitreal Implant for Previously Untreated Macular Edema due to Retinal Vein Occlusion: An Open-label Phase IV Study in China
Dexamethasone Intravitreal Implant for Previously Untreated Macular Edema due to Retinal Vein Occlusion: An Open-label Phase IV Study in China Open
Introduction/objective Effective treatment of retinal vein occlusion (RVO) is critical to improve vision outcomes. The requirement for repeated intravitreal injection of available therapies highlights the need for treatments with reduced d…
View article: Corrigendum: Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats
Corrigendum: Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats Open
[This corrects the article DOI: 10.3389/fphar.2024.1517127.].
View article: Cataract Surgery in Eyes with Microphthalmos and/or Uveal Coloboma
Cataract Surgery in Eyes with Microphthalmos and/or Uveal Coloboma Open
Introduction: Cataract may cause severe visual impairment in eyes with microphthalmos (MO) and uveal coloboma (UC). Despite their similarities, distinguishing between these conditions is crucial for cataract surgery. We aimed to compare co…
View article: Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H <sup>+</sup> -ATPase
Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H <sup>+</sup> -ATPase Open
The vacuolar-type H+-ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. Its activity and assembly are tightly controlled by multiple pathways, of which phosphorylation…
View article: Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target
Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target Open
Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of bone homeostasis can lead to the development of metabolic bone diseases such as osteoporosis and osteoarthritis. The maintenance…
View article: Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats
Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats Open
Objective To optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18 F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats. Methods A more electron-deficient n…
View article: Regulatory Role of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Loaded with miRNA-122 in the Progression of Osteoarthritis
Regulatory Role of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Loaded with miRNA-122 in the Progression of Osteoarthritis Open
ObjectiveThe aim was to design and construct engineered exosomes carrying miR-122 and miR-122 inhibitors, and to observe the effects of intra-articular injection on articular cartilage and the progression of osteoarthritis (OA) in rats, wi…
View article: Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival
Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival Open
Background: T cell dysfunction, which includes exhaustion, anergy, and senescence, is a distinct T cell differentiation state that occurs after antigen exposure. Although T cell dysfunction has been a cornerstone of cancer immunotherapy, i…
View article: Inhibition of Golgi stress alleviates sepsis-induced cardiomyopathy by reducing inflammation and apoptosis
Inhibition of Golgi stress alleviates sepsis-induced cardiomyopathy by reducing inflammation and apoptosis Open
Golgi stress mediates SIC, and the inhibition of Golgi stress can improve SIC by inhibiting apoptosis and inflammation.
View article: Effect evaluation of different preventive measures for ileus after abdominal operation: A systematic review and network meta-analysis
Effect evaluation of different preventive measures for ileus after abdominal operation: A systematic review and network meta-analysis Open
This network meta-analysis determined that oral opioid antagonists and EA combined with chewing gum are the most effective treatments and optimal interventions for reducing the incidence of postoperative ileus. However, methods such as abd…
View article: Amine-Free Conventional Hydrothermal Synthesis of Pure Silicon Mfi Zeolite
Amine-Free Conventional Hydrothermal Synthesis of Pure Silicon Mfi Zeolite Open
View article: Setd5 Facilitates Stemness And Represses Ferroptosis Via M6a-Mediating Pkm2 Stabilization in Non-Small Cell Lung Cancer
Setd5 Facilitates Stemness And Represses Ferroptosis Via M6a-Mediating Pkm2 Stabilization in Non-Small Cell Lung Cancer Open
View article: Amine-Free Synthesis of Silicalite-1 Zeolites With Abundant Defect Sites
Amine-Free Synthesis of Silicalite-1 Zeolites With Abundant Defect Sites Open
View article: Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model
Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model Open
Background: Homoharringtonine (HHT) is an effective anti-inflammatory, anti-viral, and anti-tumor protein synthesis inhibitor that has been applied clinically. Here, we explored the therapeutic effects of HHT in a mouse heart transplant mo…
View article: SAT652 The Expression Of The Immunoproteasome Subunit Psmb9 Is Related To Obesity And The Differentiation Of Human Preadipocytes
SAT652 The Expression Of The Immunoproteasome Subunit Psmb9 Is Related To Obesity And The Differentiation Of Human Preadipocytes Open
Disclosure: Y. Cui: None. X. Zhang: None. L. You: None. H. Zhong: None. X. Cui: None. C. Ji: None. Obesity and its associated chronic diseases, such as type 2 diabetes mellitus, hypertension, and coronary artery disease, afflicting adults …
View article: Inhibitors of the CD73-adenosinergic checkpoint as promising combinatory agents for conventional and advanced cancer immunotherapy
Inhibitors of the CD73-adenosinergic checkpoint as promising combinatory agents for conventional and advanced cancer immunotherapy Open
The cell surface enzyme CD73 is increasingly appreciated as a pivotal non-redundant immune checkpoint (IC) in addition to PD-1/PD-L1 and CTLA-4. CD73 produces extracellular adenosine (eADO), which not only inhibits antitumor T cell activit…
View article: Data from Rescue of Notch-1 Signaling in Antigen-Specific CD8<sup>+</sup> T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer
Data from Rescue of Notch-1 Signaling in Antigen-Specific CD8<sup>+</sup> T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer Open
An impaired antitumor immunity is found in patients with cancer and represents a major obstacle in the successful development of different forms of immunotherapy. Signaling through Notch receptors regulates the differentiation and function…
View article: Extract of Plastrum Testudinis through miR-214 mediated Wnt/β-catenin signaling stimulating bone formation
Extract of Plastrum Testudinis through miR-214 mediated Wnt/β-catenin signaling stimulating bone formation Open
Plastrum Testudinis (PT) is known as Traditional Chinese Medicine, which has commonly been used to treat and prevent bone metabolism for many years. However, the pharmacological mechanisms have not yet been fully clarified. In this study, …
View article: Study on the mechanism of American ginseng extract for treating type 2 diabetes mellitus based on metabolomics
Study on the mechanism of American ginseng extract for treating type 2 diabetes mellitus based on metabolomics Open
American ginseng extract (AGE) is an efficient and low-toxic adjuvant for type 2 diabetes mellitus (T2DM). However, the metabolic mechanisms of AGE against T2DM remain unknown. In this study, a rat model of T2DM was created and administere…
View article: High-salt diet accelerates bone loss accompanied by activation of ion channels related to kidney and bone tissue in ovariectomized rats
High-salt diet accelerates bone loss accompanied by activation of ion channels related to kidney and bone tissue in ovariectomized rats Open
View article: Frequency-dependent alterations in the default mode network during general anesthesia: a study in the rat
Frequency-dependent alterations in the default mode network during general anesthesia: a study in the rat Open
The anesthetic states induced by general anesthesia are accompanied by changes in functional and effective connectivity in brain networks. Considering the perturbations in oscillations produced by anesthesia, we postulated that the capabil…
View article: Combined exploration of the mechanism of Sang Xing Decoction in the treatment of smoke-induced acute bronchitis from protein and metabolic levels
Combined exploration of the mechanism of Sang Xing Decoction in the treatment of smoke-induced acute bronchitis from protein and metabolic levels Open
Sang Xing decoction (SXD) is a typical prescription for treating "warm dryness" in traditional Chinese medicine (TCM), which is equivalent to respiratory diseases such as acute bronchitis in modern medicine. However, its mechanism of actio…
View article: Untargeted metabolomics analysis of the anti-diabetic effect of Red ginseng extract in Type 2 diabetes Mellitus rats based on UHPLC-MS/MS
Untargeted metabolomics analysis of the anti-diabetic effect of Red ginseng extract in Type 2 diabetes Mellitus rats based on UHPLC-MS/MS Open
View article: miR-27a-5p—Abundant Small Extracellular Vesicles Derived From Epimedium-Preconditioned Bone Mesenchymal Stem Cells Stimulate Osteogenesis by Targeting Atg4B-Mediated Autophagy
miR-27a-5p—Abundant Small Extracellular Vesicles Derived From Epimedium-Preconditioned Bone Mesenchymal Stem Cells Stimulate Osteogenesis by Targeting Atg4B-Mediated Autophagy Open
Osteoporosis (OP) is a disease affecting the elderly and is characterized by incremental fractures and bone fragility. Small extracellular vesicles (sEVs) derived from mesenchymal stem cells have been demonstrated to possess potent regener…
View article: High sodium chloride affects BMP-7 and 1α-hydroxylase levels through NCC and CLC-5 in NRK-52E cells
High sodium chloride affects BMP-7 and 1α-hydroxylase levels through NCC and CLC-5 in NRK-52E cells Open
A diet high in sodium chloride (NaCl) can affect renal function damage and increase urinary calcium excretion, leading to bone loss. in renal tubules, Na-Cl co-transporter (NCC) and chloride channel 5 (CLC-5) are involved in regulating uri…
View article: miR-330–5p in Small Extracellular Vesicles Derived From Plastrum testudinis-Preconditioned Bone Mesenchymal Stem Cells Attenuates Osteogenesis by Modulating Wnt/β-Catenin Signaling
miR-330–5p in Small Extracellular Vesicles Derived From Plastrum testudinis-Preconditioned Bone Mesenchymal Stem Cells Attenuates Osteogenesis by Modulating Wnt/β-Catenin Signaling Open
The bone microenvironment is crucial for the growth and development of different types of osteocytes. Small extracellular vesicles (sEVs) secreted by bone mesenchymal stem cells are delivered to target cells where their contents regulate b…
View article: Progress in the pathogenesis and treatment of Coats disease
Progress in the pathogenesis and treatment of Coats disease Open
Coats disease is characterized by abnormal dilation of retinal capillaries and exudation of the inner and outer layers of the eye retina. It can be mostly seen in male teenagers. So far, there have no clear etiology and pathological mechan…