Ruhong Zhou
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View article: A skin-permeable polymer for non-invasive transdermal insulin delivery
A skin-permeable polymer for non-invasive transdermal insulin delivery Open
Non-invasive skin permeation is widely used for convenient transdermal delivery of small-molecule therapeutics (less than 500 Da) with appropriate hydrophobicities 1 . However, it has long been deemed infeasible for large molecules—particu…
View article: Assessing Computational Strategies for the Evaluation of Antibody Binding Affinities
Assessing Computational Strategies for the Evaluation of Antibody Binding Affinities Open
Accurate evaluation of binding affinity is critical in drug discovery to identify molecules that bind strongly to their targets while minimizing off-target effects. Although binding affinity calculations are theoretically well defined, the…
View article: DFMA-DETR: a pomegranate maturity detection algorithm based on dual-domain feature modulation and enhanced attention
DFMA-DETR: a pomegranate maturity detection algorithm based on dual-domain feature modulation and enhanced attention Open
Accurate detection of pomegranate maturity plays a crucial role in optimizing harvesting decisions and enhancing economic benefits. Conventional approaches encounter significant challenges in complex agricultural scenarios, including limit…
View article: Design of TCR-mimicking binders for pHLA with high potency
Design of TCR-mimicking binders for pHLA with high potency Open
The rational design of high-specificity binders to peptide–HLA (pHLA) complexes remains a major challenge in personalized immunotherapy, particularly for shared neoantigens with single-point mutations. To address this, we have developed an…
View article: Assessing computational strategies for the evaluation of antibody binding affinities
Assessing computational strategies for the evaluation of antibody binding affinities Open
Accurate evaluation of binding affinity is critical in drug discovery to identify molecules that bind strongly to their targets while minimizing off-target effects. Although binding affinity calculations are theoretically well-defined, the…
View article: In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies
In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies Open
Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-…
View article: In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies
In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies Open
Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-…
View article: BioLab: End-to-End Autonomous Life Sciences Research with Multi-Agents System Integrating Biological Foundation Models
BioLab: End-to-End Autonomous Life Sciences Research with Multi-Agents System Integrating Biological Foundation Models Open
Scientific discovery in the life sciences remains hindered by fragmented workflows, narrow-scope computational models, and inefficient links between in silico prediction and wet-lab validation. We present BioLab, a multi-agent system that …
View article: Numerical simulation of high-temperature necking evolution considering strain-rate dependence and strain softening
Numerical simulation of high-temperature necking evolution considering strain-rate dependence and strain softening Open
Necking evolution is a process of non-uniform deformation with varying strain rates, and accurate predictions of this process, taking into account strain rate dependence and strain softening, remain a challenge. In this work, based on the …
View article: Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer
Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer Open
While dysregulation of polyamine metabolism is frequently observed in cancer, it is unknown how polyamines alter the tumor microenvironment (TME) and contribute to therapeutic resistance. Analysis of polyamines in the plasma of pancreatic …
View article: Reengineering the antigen optimization process for superior neoantigen vaccine design
Reengineering the antigen optimization process for superior neoantigen vaccine design Open
Identifying effective neoantigen sequences is essential for enhancing anti-tumor immunity. However, the vast sequence space (>10 9 possible peptides) and limited accuracy of existing immunogenicity predictors hinder efficient vaccine desig…
View article: Role of Charge Density of Polycations in DNA Complexation and Condensation
Role of Charge Density of Polycations in DNA Complexation and Condensation Open
Polycationic gene vectors have been studied extensively for gene delivery, and the charge density of polycations plays a pivotal role in condensing nucleic acids. Recently, we have synthesized two kinds of polycations with varied charge de…
View article: A free energy perturbation-assisted machine learning strategy for mimotope screening in neoantigen-based vaccine design
A free energy perturbation-assisted machine learning strategy for mimotope screening in neoantigen-based vaccine design Open
Neoantigen-based immunotherapy has emerged as a promising approach for cancer treatment. One key strategy in neoantigen-based vaccine design is to alter known neoantigens into enhanced mimotopes that elicit more robust immune responses. Ho…
View article: Cross-talk between RNA secondary and three-dimensional structure prediction: a comprehensive study
Cross-talk between RNA secondary and three-dimensional structure prediction: a comprehensive study Open
In recent years, various computational methods have been developed to predict the three-dimensional (3D) structures of RNAs. Due to its hierarchical folding property, RNA secondary (2D) structure is usually used as input for 3D structure p…
View article: <i>In silico</i> design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies
<i>In silico</i> design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies Open
Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO ( C ompute…
View article: Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis
Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis Open
Granulomatous mastitis (GM) is a form of non-lactational breast inflammation that is closely associated with autoimmune processes, however its underlying pathogenesis remains elusive. In this study, we employed single-cell RNA sequencing (…
View article: Recent advances in antibody optimization based on deep learning methods
Recent advances in antibody optimization based on deep learning methods Open
Antibodies currently comprise the predominant treatment modality for a variety of diseases; therefore, optimizing their properties rapidly and efficiently is an indispensable step in antibody-based drug development. Inspired by the great s…
View article: Neuromorphic Transistors Integrating Photo‐Sensor, Optical Memory and Visual Synapses for Artificial Vision Application
Neuromorphic Transistors Integrating Photo‐Sensor, Optical Memory and Visual Synapses for Artificial Vision Application Open
In commercial artificial vision system (AVS), the sensing, storage, and computing units are usually physically separated due to their architecture and performance gaps, which thus increases the volume, complexity, and energy loss. This wor…
View article: Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective
Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective Open
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, the number of AD cases is projected to exceed 131 million, placing significant strain on healthcare systems and economies worl…
View article: Ultra‐High‐Density Single‐Atom Catalysts on Oxides via Metal‐Support Interactions
Ultra‐High‐Density Single‐Atom Catalysts on Oxides via Metal‐Support Interactions Open
Metal‐support interaction (MSI) effects offer a powerful strategy for achieving ultra‐high‐density single‐atom catalysts (UHD‐SACs) on oxides. This review explores the synthesis strategies for UHD‐SACs on oxide supports and systematically …
View article: An experimental study on the combustion characteristics of YJV and YC cables in urban utility tunnels
An experimental study on the combustion characteristics of YJV and YC cables in urban utility tunnels Open
Cable fires in utility tunnels can result in significant economic losses and potentially cause citywide disruptions. Therefore, a comprehensive study on cable combustion characteristics under thermal stress holds paramount importance both …
View article: Mina53 catalyzes arginine demethylation of p53 to promote tumor growth
Mina53 catalyzes arginine demethylation of p53 to promote tumor growth Open
Arginine methylation is a common post-translational modification that plays critical roles in many biological processes. However, the existence of arginine demethylases that remove the modification has not been fully established. Here, we …
View article: Promotion of triple negative breast cancer immunotherapy by combining bioactive radicals with immune checkpoint blockade
Promotion of triple negative breast cancer immunotherapy by combining bioactive radicals with immune checkpoint blockade Open
Although immunotherapy has revolutionized clinical cancer treatment, the efficacy is limited due to the lack of tumor-associated antigens (TAAs) and the presence of compensatory immune checkpoints. To overcome the deficiency, a nano-system…
View article: RNAGenesis: A Generalist Foundation Model for Functional RNA Therapeutics
RNAGenesis: A Generalist Foundation Model for Functional RNA Therapeutics Open
RNA molecules are central to gene regulation, catalysis, and molecular recognition, and offer broad opportunities for therapeutic applications. However, uncovering their complex sequence, structure, and function relationships, particularly…
View article: Manga Generation via Layout-controllable Diffusion
Manga Generation via Layout-controllable Diffusion Open
Generating comics through text is widely studied. However, there are few studies on generating multi-panel Manga (Japanese comics) solely based on plain text. Japanese manga contains multiple panels on a single page, with characteristics s…