Ruan Carlos Macêdo de Moraes
YOU?
Author Swipe
View article: Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila
Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila Open
Background: Apolipoprotein E (ApoE) is the leading genetic risk factor for late-onset Alzheimer’s disease (AD), which is the leading cause of dementia worldwide. Most people have two ApoE-ε3 (ApoE3) alleles, while ApoE-ε2 (ApoE2) is protec…
View article: Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer’s-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function
Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer’s-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function Open
Alzheimer's disease (AD) is a complex neurodegenerative process, also considered a metabolic condition due to alterations in glucose metabolism and insulin signaling pathways in the brain, which share similarities with diabetes. This study…
View article: Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila Open
Huntington’s disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that leads to a polyglutamine (PQ) repeat in the huntingtin protein, wh…
View article: Circadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding
Circadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding Open
Circadian rhythms are present throughout biology, from the molecular level to complex behaviors such as eating and sleeping. They are driven by molecular clocks within cells, and different tissues can have unique rhythms. Circadian disrupt…
View article: Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats
Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats Open
View article: The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model
The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1α, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model Open
The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic path…
View article: Efeito da suplementação com ácido α-lipóico no estresse oxidativo nos tecidos cardíaco e hepático de camundongos treinados em endurance submetidos a um exercício exaustivo
Efeito da suplementação com ácido α-lipóico no estresse oxidativo nos tecidos cardíaco e hepático de camundongos treinados em endurance submetidos a um exercício exaustivo Open
Introdução: O exercício de alta intensidade promove um aumento na produção de espécies reativas, o que pode ser prejudicial para a saúde e função de diversos órgãos. Objetivo: Analisar o efeito da suplementação com ácido α-lipóico contra o…
View article: Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia
Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia Open
Background Cachexia is a paraneoplastic syndrome that accompanies and compromises cancer treatment, especially in advanced stages, affecting the metabolism and function of several organs. The adipose tissue is the first to respond to the p…
View article: A novel supplement with yeast β-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice
A novel supplement with yeast β-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice Open
We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis.
View article: Efeitos da suplementação de benfotiamina, um análogo sintético da vitamina B1, sobre o metabolismo energético neuronal e progressão da neurodegeneração em um modelo experimental de doença de Alzheimer.
Efeitos da suplementação de benfotiamina, um análogo sintético da vitamina B1, sobre o metabolismo energético neuronal e progressão da neurodegeneração em um modelo experimental de doença de Alzheimer. Open
Estudos sugerem que distúrbios no metabolismo energético e na sinalização da insulina cerebral estão associados com a progressão da doença de Alzheimer (DA) e o déficit cognitivo. A tiamina é um co-fator enzimático limitante para a ativida…
View article: NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance
NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance Open
Sporadic Alzheimer’s disease (sAD) is associated with energy metabolism deficiency and impairment of insulin receptor (IR) signaling in the brain. In this context, low doses of intracerebroventricular (icv) injection of streptozotocin (STZ…
View article: Effects of the supplementation with alpha-lipoic acid on muscular antioxidant biomarkers of trained mice
Effects of the supplementation with alpha-lipoic acid on muscular antioxidant biomarkers of trained mice Open
BACKGROUND: Performing high intensity or exhaustive exercise can lead to muscle damage such as injuries, chronic fatigue and overtraining, partly due to the high synthesis of reactive oxygen species. The α-lipoic acid (ALA) and its reduced…
View article: <b>Use of murinometrics indices and bioelectrical impedance (BIA) in the determination of experimental obesity in oophorectomized rats
<b>Use of murinometrics indices and bioelectrical impedance (BIA) in the determination of experimental obesity in oophorectomized rats Open
In this study, we tested the use of murinometric indices and bioimpedance (BIA) to determine obesity in rats. Female Wistar rats (8 weeks/130-160 g) were divided into control and oophorectomy group. The Body Mass Index (BMI) and Lee index …