Wen Ruan
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View article: A novel 3A-based indirect enzyme-linked immunosorbent assay for serological testing of Senecavirus A
A novel 3A-based indirect enzyme-linked immunosorbent assay for serological testing of Senecavirus A Open
Senecavirus A (SVA) can cause a contagious porcine disease characterized by vesicular lesions on the mouth and feet. Its clinical symptoms are extremely similar to those of porcine foot-and-mouth disease, swine vesicular disease, and vesic…
View article: Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation
Pregnane X receptor (PXR) as a prognostic marker and therapeutic target in kidney renal clear cell carcinoma (KIRC) via AMPK pathway regulation Open
View article: Anemia increases the risk of venous thromboembolism? Insights from genome-wide association studies
Anemia increases the risk of venous thromboembolism? Insights from genome-wide association studies Open
Anemia individuals face an increased risk of embolism and thrombosis events, and AA exhibits a potential association with VTE. Nevertheless, a comprehensive comprehension of the precise underlying mechanisms linking anemia/AA and VTE neces…
View article: The value of 11-oxygenated androgens in the diagnosis and treatment of 21-hydroxylase deficiency
The value of 11-oxygenated androgens in the diagnosis and treatment of 21-hydroxylase deficiency Open
Background In 21-hydroxylase deficiency (21-OHD), traditional androgens like testosterone (T), androstenedione (A4), and dihydrotestosterone (DHT) are commonly used for monitoring disease. However, these biomarkers alone cannot fully expla…
View article: Performance of Risk‐Stratification Scores for Patients With Pulmonary Arterial Hypertension in a Multi‐Ethnic Asian Population
Performance of Risk‐Stratification Scores for Patients With Pulmonary Arterial Hypertension in a Multi‐Ethnic Asian Population Open
Guidelines recommend risk stratification of pulmonary arterial hypertension (PAH) patients to guide management. There are currently several risk stratification scores available, which have largely been validated in various pulmonary hypert…
View article: Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension in Singapore
Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension in Singapore Open
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by significant morbidity and mortality. Intravenous (IV) epoprostenol (Veletri, Johnson & Johnson, US), a prostacyclin analogue, has been shown to improve exercis…
View article: Validation of the OPTICS and H2FPEF risk scores for post-capillary pulmonary hypertension in an asian cohort
Validation of the OPTICS and H2FPEF risk scores for post-capillary pulmonary hypertension in an asian cohort Open
Background The differentiation between pre- and post-capillary pulmonary hypertension (PH) plays a significant impact in the management of PH patients. Right heart catheterization (RHC) serves as an important test to facilitate this differ…
View article: Outcomes of selexipag for treatment of pulmonary arterial hypertension in an Asian population
Outcomes of selexipag for treatment of pulmonary arterial hypertension in an Asian population Open
Dear Editor, Pulmonary arterial hypertension (PAH) is a progressive condition characterised by increased pulmonary arterial pressure and pulmonary vascular resistance, resulting in right ventricular dysfunction and eventually cardiac failu…
View article: Clinical profile and outcomes in patients with moderate to severe aortic stenosis with or without concomitant chronic kidney disease
Clinical profile and outcomes in patients with moderate to severe aortic stenosis with or without concomitant chronic kidney disease Open
Introduction: Management of aortic stenosis (AS) in patients with chronic kidney disease (CKD) may often be overlooked, and this could confer poorer outcomes. Methods: Consecutive patients ( n = 727) with index echocardiographic diagnosis …
View article: Allometric Indexing of Left Ventricular Mass in Echocardiography: Differences Between Men and Women
Allometric Indexing of Left Ventricular Mass in Echocardiography: Differences Between Men and Women Open
Background: As echocardiographic left ventricular mass does not scale linearly with body surface area, indexing of left ventricular mass to height raised to the power exponent b has been proposed (‘allometric indexing’). Pooling data from …
View article: Real-world outcomes of Selexipag for treatment of pulmonary hypertension in an Asian population
Real-world outcomes of Selexipag for treatment of pulmonary hypertension in an Asian population Open
Funding Acknowledgements Type of funding sources: None. Introduction Selexipag is an oral selective prostacyclin IP receptor agonist indicated for treatment of pulmonary arterial hypertension (PAH). Data on its real-world safety and effica…
View article: Identification of cell senescence molecular subtypes in prediction of the prognosis and immunotherapy of hepatitis B virus-related hepatocellular carcinoma
Identification of cell senescence molecular subtypes in prediction of the prognosis and immunotherapy of hepatitis B virus-related hepatocellular carcinoma Open
Hepatitis B virus (HBV)-infected hepatocellular carcinoma (HCC) has a high incidence and fatality rate worldwide, being among the most prevalent cancers. The growing body of data indicating cellular senescence (CS) to be a critical factor …
View article: Risk stratification and prognosis in pulmonary arterial hypertension: the Singapore experience
Risk stratification and prognosis in pulmonary arterial hypertension: the Singapore experience Open
Funding Acknowledgements Type of funding sources: None. Aims & Background: Guidelines recommend the risk stratification of patients with pulmonary arterial hypertension (PAH) at baseline and on follow-up, so as to guide the management and …
View article: Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension: the Singapore experience
Intravenous epoprostenol therapy in the treatment of pulmonary arterial hypertension: the Singapore experience Open
Funding Acknowledgements Type of funding sources: None. Background Pulmonary arterial hypertension (PAH) is a progressive disease with significant morbidity and mortality. While intravenous (IV) Epoprostenol, a prostacyclin analogue, has b…
View article: Spectral characteristics of low excited state of strontium monobromide molecule
Spectral characteristics of low excited state of strontium monobromide molecule Open
The electronic structures and single point energy of 14 lowest electronic states of 88Sr79Br molecule are optimized by using the internal contraction multi-reference configuration interaction method and relativistic e…
View article: Right ventricular energetic biomarkers from 4D Flow CMR are associated with exertional capacity in pulmonary arterial hypertension
Right ventricular energetic biomarkers from 4D Flow CMR are associated with exertional capacity in pulmonary arterial hypertension Open
View article: Age- and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians
Age- and Sex-Specific Changes in CMR Feature Tracking-Based Right Atrial and Ventricular Functional Parameters in Healthy Asians Open
Cardiovascular magnetic resonance (CMR) is the reference standard for non-invasive assessment of right-sided heart function. Recent advances in CMR post-processing facilitate quantification of tricuspid annular (TA) dynamics and longitudin…
View article: Implications of Coexisting Aortic Regurgitation in Patients With Aortic Stenosis
Implications of Coexisting Aortic Regurgitation in Patients With Aortic Stenosis Open
In patients with AS, coexisting AR was associated with changes in echocardiographic profile and adverse outcomes.
View article: Pulmonary endarterectomy and balloon pulmonary angioplasty in chronicthromboembolic pulmonary hypertension: The Singapore experience
Pulmonary endarterectomy and balloon pulmonary angioplasty in chronicthromboembolic pulmonary hypertension: The Singapore experience Open
Dear Editor, Chronic thromboembolic pulmonary hypertension (CTEPH) is a pulmonary hypertension caused by mechanical obstruction of the pulmonary arteries by organised thrombi and microvascular arteriopathy.It occurs as a complication of pu…
View article: Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions
Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions Open
Quantitative RV fast strain and strain rate parameters assessed from CMR identify abnormalities of RV function in rTOF and PAH and are predictive of exercise capacity, RV decompensation and clinical risks in these patients. Trial registry …
View article: Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions
Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions Open
Background Parameters of myocardial deformation may provide improved insights into right ventricular (RV) dysfunction. We quantified RV longitudinal myocardial function using a fast, semi-automated method and investigated its diagnostic an…
View article: Containment of COVID-19 and reduction in healthcare-associated respiratory viral infections through a multi-tiered infection control strategy
Containment of COVID-19 and reduction in healthcare-associated respiratory viral infections through a multi-tiered infection control strategy Open
View article: The Prevention and Control Experience of Maternal Health Care from Chengu, China During the COVID-19 Epidemic
The Prevention and Control Experience of Maternal Health Care from Chengu, China During the COVID-19 Epidemic Open
Chunrong Li,* Li Tang,* Yingjuan Luo, Ting Lai, Lingling Gu, Yumei Wang, Liu Yang, Longrong Ran, Rongkang Wen, Yonghong Lin Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technolog…
View article: Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension
Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension Open
Introduction: Chronic thromboembolic pulmonary hypertension (CTEPH) is a known sequela after acute pulmonary embolism (PE). It is a debilitating disease, and potentially fatal if left untreated. This review provides a clinically relevant o…
View article: Surveillance for COVID-19 in Cardiac Inpatients: Containing COVID-19 in a Specialized Cardiac Centre
Surveillance for COVID-19 in Cardiac Inpatients: Containing COVID-19 in a Specialized Cardiac Centre Open
View article: Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension
Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension Open
Introduction: Chronic thromboembolic pulmonary hypertension (CTEPH) is a known sequela after acute pulmonary embolism (PE). It is a debilitating disease, and potentially fatal if left untreated. This review provides a clinically relevant o…
View article: Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort
Mortality and hospitalization outcomes of interstitial lung disease and pulmonary hypertension in the Singapore systemic sclerosis cohort Open
PAH is an independent risk factor of mortality in SSc. Increased hospitalization rate was not associated with SSc groups. Other factors associated with increased mortality and hospital admissions were identified.
View article: Associations between Skeletal Muscle and Myocardium in Aging: A Syndrome of “Cardio‐Sarcopenia”?
Associations between Skeletal Muscle and Myocardium in Aging: A Syndrome of “Cardio‐Sarcopenia”? Open
Objectives The link between skeletal muscle and heart disease remains intriguing. It is unknown how skeletal muscle may be associated with aspects of myocardial structure and function, particularly in the presence of aging‐related sarcopen…
View article: Downregulated level of insulin in COPD patients during AE; role beyond glucose control?
Downregulated level of insulin in COPD patients during AE; role beyond glucose control? Open
Wenjing Ruan,1 Chao Yan,1 Huiqi Zhu,1 Shuwen Wang,1 Xuan Jia,1 Lingyan Shao,1 Zhihao Xu,2 Kejing Ying11Department of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of C…
View article: Impaired Cardiovascular Magnetic Resonance–Derived Rapid Semiautomated Right Atrial Longitudinal Strain Is Associated With Decompensated Hemodynamics in Pulmonary Arterial Hypertension
Impaired Cardiovascular Magnetic Resonance–Derived Rapid Semiautomated Right Atrial Longitudinal Strain Is Associated With Decompensated Hemodynamics in Pulmonary Arterial Hypertension Open
Background The transition of right ventricle (RV) from a compensated to decompensated state contributes to survival in pulmonary arterial hypertension (PAH). This study investigates the significance of right atrial (RA) dysfunction on dise…