Ruben Declercq
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The PET tracer [ <sup>11</sup> C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease Open
[ 11 C]MK-6884 is an M4R-specific PET tracer for quantifying target engagement in brain and providing insights into AD neuropathology.
View article: IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS
IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS Open
The M4 muscarinic cholinergic receptor may play important roles in the pathophysiology and treatment of Alzheimer's disease (AD). This study aimed to assess the utility of [11C]MK-6884, a novel PET radiotracer targeting the M4 allosteric m…
View article: Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with <sup>18</sup>F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with <sup>18</sup>F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles Open
18F-MK-6240 (18F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective, subnanomolar-affinity PET tracer for imaging neurofibrillary tangles (NFTs). Plasma kinetics, brain uptake, and preliminary qu…
View article: [P3–381]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS
[P3–381]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS Open
Dementia correlates strongly with the extent of neurofibrillary tangles (NFT). We recently disclosed [18F]MK-6240, a potent and selective NFT radioligand designed to be more specific and sensitive than previously known NFT PET radioligands…
View article: [IC‐P‐177]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS
[IC‐P‐177]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS Open
Dementia correlates strongly with the extent of neurofibrillary tangles (NFT). We recently disclosed [18F]MK-6240, a potent and selective NFT radioligand designed to be more specific and sensitive than previously known NFT PET radioligands…