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View article: DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin Open
SUMMARY The proto-oncogene c-MYC is a key representative of the MYC transcription factor network regulating growth and metabolism. MML-1 (Myc- and Mondo-like) is its homolog in C. elegans . The functional and molecular cooperation between …
View article: The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters
The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters Open
The predominant and ubiquitously expressed C. elegans histone H3 lysine 79 methyltransferase DOT-1.1 and its interacting partner, ZFP-1, play important roles in negatively modulating widely and highly expressed genes through promoter bindi…
View article: Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland
Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland Open
In mammals, imprinted genes regulate many critical endocrine processes such as growth, the onset of puberty and maternal reproductive behaviour. Human imprinting disorders (IDs) are caused by genetic and epigenetic mechanisms that alter th…
View article: Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions
Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions Open
The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 methylation (H3K79me) have been correlated with enhancers in …
View article: ChIPdig: a comprehensive user-friendly tool for mining multi-sample ChIP-seq data
ChIPdig: a comprehensive user-friendly tool for mining multi-sample ChIP-seq data Open
In recent years, epigenetic research has enjoyed explosive growth as high-throughput sequencing technologies become more accessible and affordable. However, this advancement has not been matched with similar progress in data analysis capab…
View article: DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in <i>Caenorhabditis elegans</i>
DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in <i>Caenorhabditis elegans</i> Open
Methylation of histone H3 on lysine 79 (H3K79) by DOT1L is associated with actively transcribed genes. Earlier, we described that DOT-1.1, the Caenorhabditis elegans homolog of mammalian DOT1L, cooperates with the chromatin-binding protein…
View article: Interplay between small RNA pathways shapes chromatin landscapes in C. elegans
Interplay between small RNA pathways shapes chromatin landscapes in C. elegans Open
The nematode Caenorhabditis elegans contains several types of endogenous small interfering RNAs (endo-siRNAs) produced by RNA-dependent RNA polymerase (RdRP) complexes. Both ‘silencing’ siRNAs bound by Worm-specific Argonautes (WAGO) and ‘…
View article: The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art
The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art Open
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the metabolism of the essential amino acid methionine. Hcy is considered a risk factor for atherosclerosis and cardiovascular disease (CVD), but the molec…
View article: DOT1L suppresses nuclear RNAi originating from enhancer elements in <i>Caenorhabditis elegans</i>
DOT1L suppresses nuclear RNAi originating from enhancer elements in <i>Caenorhabditis elegans</i> Open
Methylation of histone H3 on lysine 79 (H3K79) by DOT1L is associated with actively transcribed genes. Earlier, we described that DOT-1.1, the Caenorhabditis elegans DOT1L homologue, cooperates with the chromatin-binding protein ZFP-1 (AF1…
View article: The interplay between small RNA pathways shapes chromatin landscapes in<i>C. elegans</i>
The interplay between small RNA pathways shapes chromatin landscapes in<i>C. elegans</i> Open
The nematode C. elegans contains several types of endogenous small interfering RNAs (endo-siRNAs) produced by RNA-dependent RNA polymerase (RdRP) complexes. Both “silencing” siRNAs bound by Worm-specific Argonautes (WAGO) and “activating” …
View article: Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells
Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells Open
Elevated plasma total homocysteine (tHcy) is associated with increased risk of cardiovascular disease, but the mechanisms underlying this association are not completely understood. Cellular hypomethylation has been suggested to be a key pa…
View article: ChIPdig: a comprehensive user-friendly tool for mining multi-sample ChIP-seq data
ChIPdig: a comprehensive user-friendly tool for mining multi-sample ChIP-seq data Open
Background In recent years, epigenetic research has enjoyed explosive growth as high-throughput sequencing technologies become more accessible and affordable. However, this advancement has not been matched with similar progress in data ana…