Ruben Schmidt
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View article: LGL-1 and the RhoGAP protein PAC-1 redundantly control polarization of the <i>C. elegans</i> embryonic epidermal epithelium
LGL-1 and the RhoGAP protein PAC-1 redundantly control polarization of the <i>C. elegans</i> embryonic epidermal epithelium Open
The formation of an apical–basal axis of polarity is essential for the organization and functioning of epithelial cells. Apical–basal polarity is established by cortical polarity proteins that define the apical, junctional, and basolateral…
View article: Brain magnetic resonance imaging of patients with spinal muscular atrophy type 2 and 3
Brain magnetic resonance imaging of patients with spinal muscular atrophy type 2 and 3 Open
MRI shows structural changes in motor and non-motor regions of the cortex and the thalamus of patients with SMA type 2 and 3, indicating that SMA pathology is not confined to motor neurons.
View article: Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions
Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions Open
Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using Caenorhabditis el…
View article: Author response: Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions
Author response: Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Interme…
View article: Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans
Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans Open
Crumbs proteins are evolutionarily conserved transmembrane proteins with essential roles in promoting the formation of the apical domain in epithelial cells. The short intracellular tail of Crumbs proteins are known to interact with severa…
View article: ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine
ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine Open
Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na + /H + exchanger 3 regu…
View article: Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells
Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells Open
The conserved adapter protein Scribble (Scrib) plays essential roles in a variety of cellular processes, including polarity establishment, proliferation, and directed cell migration. While the mechanisms through which Scrib promotes epithe…
View article: ERM-1 phosphorylation and NRFL-1 redundantly control lumen formation in the <i>C. elegans</i> intestine
ERM-1 phosphorylation and NRFL-1 redundantly control lumen formation in the <i>C. elegans</i> intestine Open
Reorganization of the plasma membrane and underlying actin cytoskeleton into specialized domains is essential for the functioning of most polarized cells in animals. Proteins of the ezrin-radixin-moesin (ERM) and Na + /H + exchanger 3 regu…
View article: Characterization of the composition and functioning of the Crumbs complex in <i>C. elegans</i>
Characterization of the composition and functioning of the Crumbs complex in <i>C. elegans</i> Open
The apical domain of epithelial cells can acquire a diverse array of morphologies and functions, which is critical for the function of epithelial tissues. The Crumbs proteins are evolutionary conserved transmembrane proteins with essential…
View article: <i>Caenorhabditis elegans</i>LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells
<i>Caenorhabditis elegans</i>LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells Open
The conserved adapter protein Scribble (Scrib) plays essential roles in a variety of cellular processes, including polarity establishment, proliferation, and directed cell migration. While the mechanisms through which Scrib promotes epithe…
View article: C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during <i>Caenorhabditis</i> <i>elegans</i> development
C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during <i>Caenorhabditis</i> <i>elegans</i> development Open
ERM proteins are conserved regulators of cortical membrane specialization that function as membrane-actin linkers and molecular hubs. The activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an a…
View article: Genetic and optogenetic analysis of cell cleavage plane positioning
Genetic and optogenetic analysis of cell cleavage plane positioning Open
Cells form the basis of life. Every animal starts its life as a single cell, which generates all the other cells of the body through repeated rounds of division. To develop properly, a fertilized egg needs to generate both adequate cell nu…
View article: Optogenetic dissection of mitotic spindle positioning in vivo
Optogenetic dissection of mitotic spindle positioning in vivo Open
The position of the mitotic spindle determines the plane of cell cleavage, and thereby daughter cell location, size, and content. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules, which require…
View article: Author response: Optogenetic dissection of mitotic spindle positioning in vivo
Author response: Optogenetic dissection of mitotic spindle positioning in vivo Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The position of the mitotic s…
View article: Optogenetic dissection of mitotic spindle positioning in vivo
Optogenetic dissection of mitotic spindle positioning in vivo Open
The position of the mitotic spindle determines the plane of cell cleavage, and thereby the location, size, and content of daughter cells. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules. This …
View article: Two populations of cytoplasmic dynein contribute to spindle positioning in <i>C. elegans</i> embryos
Two populations of cytoplasmic dynein contribute to spindle positioning in <i>C. elegans</i> embryos Open
The position of the mitotic spindle is tightly controlled in animal cells as it determines the plane and orientation of cell division. Contacts between cytoplasmic dynein and astral microtubules (MTs) at the cell cortex generate pulling fo…
View article: Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function
Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function Open
Dyskinetic cerebral palsy (CP) has long been associated with basal ganglia and thalamus lesions. Recent evidence further points at white matter (WM) damage. This study aims to identify altered WM pathways in dyskinetic CP from a standardiz…
View article: Normal spindle positioning in the absence of EBPs and dynein plus-end tracking in<i>C. elegans</i>
Normal spindle positioning in the absence of EBPs and dynein plus-end tracking in<i>C. elegans</i> Open
The position of the mitotic spindle is tightly controlled in animal cells, as it determines the plane and orientation of cell division. Interactions between cytoplasmic dynein at the cortex and astral microtubules generate pulling forces t…
View article: ALS imprints on the brain linked to the connectome
ALS imprints on the brain linked to the connectome Open
In order to study the topology of functional networks, functional connectome maps are often thresholded after which only the strongest functional connections remain for analysis. The experiments described in chapter 2 show that graph metri…
View article: Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations
Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations Open
Graph theoretical analysis has become an important tool in the examination of brain dysconnectivity in neurological and psychiatric brain disorders. A common analysis step in the construction of the functional graph or network involves "th…
View article: Widespread structural brain involvement in ALS is not limited to the<i>C9orf72</i>repeat expansion
Widespread structural brain involvement in ALS is not limited to the<i>C9orf72</i>repeat expansion Open
This study shows that widespread structural brain involvement is not limited to C9+ patients, but also presents in a subgroup of C9- patients with ALS and relates to cognitive deficits. Our neuroimaging findings reveal an intermediate phen…
View article: Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans
Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans Open
During cell division, the mitotic spindle segregates replicated chromosomes to opposite poles of the cell, while the position of the spindle determines the plane of cleavage. Spindle positioning and chromosome segregation depend on pulling…
View article: Comparison of diffusion tractography and tract-tracing measures of connectivity strength in rhesus macaque connectome
Comparison of diffusion tractography and tract-tracing measures of connectivity strength in rhesus macaque connectome Open
With the mapping of macroscale connectomes by means of in vivo diffusion-weighted MR Imaging (DWI) rapidly gaining in popularity, one of the necessary steps is the examination of metrics of connectivity strength derived from these reconstr…
View article: Simulating disease propagation across white matter connectome reveals anatomical substrate for neuropathology staging in amyotrophic lateral sclerosis
Simulating disease propagation across white matter connectome reveals anatomical substrate for neuropathology staging in amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive loss of motor function. While the pathogenesis of ALS remains largely unknown, recent histological examinations of Brettschneider and co…