Rubens Costa Filho
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View article: Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux
Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux Open
Cilia are found on the epithelia of almost all metazoans, so their absence from the epithelia of all but one class of Porifera is puzzling. Homoscleromorph sponges possess ciliated epithelia, but their function and evolutionary history wit…
View article: Evaluating the Effectiveness of NOACs and LMWH in Reducing Mortality in Critically Ill Patients With COVID‐19
Evaluating the Effectiveness of NOACs and LMWH in Reducing Mortality in Critically Ill Patients With COVID‐19 Open
Severe COVID‐19 is associated with increased prothrombotic and inflammatory responses, necessitating effective anticoagulation therapy. Novel oral anticoagulants (NOACs) are being explored as potential alternatives to low‐molecular‐weight …
View article: Commentary: Evaluation of post-COVID mortality risk in cases classified as severe acute respiratory syndrome in Brazil: a longitudinal study for medium and long term
Commentary: Evaluation of post-COVID mortality risk in cases classified as severe acute respiratory syndrome in Brazil: a longitudinal study for medium and long term Open
View article: Avanços no Diagnóstico e Tratamento do Acidente Vascular Cerebral Isquêmico: Terapias Inovadoras e Abordagens de Reabilitação
Avanços no Diagnóstico e Tratamento do Acidente Vascular Cerebral Isquêmico: Terapias Inovadoras e Abordagens de Reabilitação Open
Este artigo visa discutir os avanços no diagnóstico e tratamento do Acidente Vascular Cerebral Isquêmico, utilizando a base de dados PubMed com os termos "Acidente Vascular Cerebral Isquêmico”, “Reabilitação”, “Terapias Inovadoras". Com ba…
View article: Neurotechnology and Rehabilitation: Advances in neural devices and brain-machine interfaces for post-stroke rehabilitation
Neurotechnology and Rehabilitation: Advances in neural devices and brain-machine interfaces for post-stroke rehabilitation Open
View article: The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case
The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case Open
Background: Human metapneumovirus (hMPV) is a respiratory pathogen that has gained increasing recognition due to advancements in molecular diagnostic tools, which have improved its detection and characterization. While severe disease manif…
View article: Physiological Validation of Fecal Glucocorticoids in Male and Female Primates of the Species <i>Callithrix </i><i>j</i><i>acchus</i>
Physiological Validation of Fecal Glucocorticoids in Male and Female Primates of the Species <i>Callithrix </i><i>j</i><i>acchus</i> Open
View article: Strategic Use of Intravenous Medications to Protect Target Organs in Hypertensive Emergencies
Strategic Use of Intravenous Medications to Protect Target Organs in Hypertensive Emergencies Open
View article: Evaluating the Effectiveness of NOAC and LMWHs in Reducing Mortality in Critically Ill Patients with COVID-19
Evaluating the Effectiveness of NOAC and LMWHs in Reducing Mortality in Critically Ill Patients with COVID-19 Open
Background Severe COVID-19 is associated with increased prothrombotic and inflammatory responses, necessitating effective anticoagulation therapy. Novel oral anticoagulants (NOACs) are being explored as alternatives to low-molecular-weight…
View article: NOACs Versus LMWH in Critically Ill Patients with COVID-19 Before Vaccination: A Retrospective Study
NOACs Versus LMWH in Critically Ill Patients with COVID-19 Before Vaccination: A Retrospective Study Open
View article: Vaccine-induced immune thrombotic thrombocytopenia post COVID-19 booster vaccination in Brazil: a case series
Vaccine-induced immune thrombotic thrombocytopenia post COVID-19 booster vaccination in Brazil: a case series Open
The study confirms that VITT is linked to the first exposure to adenoviral vector vaccines. Since January 2023, Brazil has recommended preferably COVID-19 messenger RNA vaccines for individuals aged 18 to 39 years. We suggest that, in the …
View article: PB0073 A Retrospective Study of Two Anticoagulation Therapies In Critically Ill Covid-19 Patients Prior to Vaccination Era
PB0073 A Retrospective Study of Two Anticoagulation Therapies In Critically Ill Covid-19 Patients Prior to Vaccination Era Open
View article: SARS-CoV-2 intra-host diversity, antibody response, and disease severity after reinfection by the variant of concern Gamma in Brazil
SARS-CoV-2 intra-host diversity, antibody response, and disease severity after reinfection by the variant of concern Gamma in Brazil Open
View article: Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies Open
View article: A case series of SARS-CoV-2 reinfections caused by the variant of concern Gamma in Brazil
A case series of SARS-CoV-2 reinfections caused by the variant of concern Gamma in Brazil Open
Summary The rapid spread of the SARS-CoV-2 Variant of Concern (VOC) Gamma during late 2020 and early 2021 in Brazilian settings with high seroprevalence raised some concern about the potential role of reinfections in driving the epidemic. …
View article: Three SARS-CoV-2 reinfection cases by the new Variant of Concern (VOC) P.1/501Y.V3
Three SARS-CoV-2 reinfection cases by the new Variant of Concern (VOC) P.1/501Y.V3 Open
The SARS-CoV-2 lineage B.1.1.28 has been evolving in Brazil since February 2020 giving origin to multiple local clades including the new Variant of Concern (VOC) designated P.1 or 501Y.V3. The recent emergence of sub-lineages with converge…
View article: Should COVID-19 be branded to viral thrombotic fever?
Should COVID-19 be branded to viral thrombotic fever? Open
Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavi…
View article: Impact of an inpatient multidisciplinary glucose control management program
Impact of an inpatient multidisciplinary glucose control management program Open
The implementation of an inpatient multidisciplinary glucose control management program led to significant reductions in hyperglycemic events. The key elements for this achievement were the development of institutional inpatient glycemic c…
View article: Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial
Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial Open
In critically ill patients with ESRD, or severe renal dysfunction, there was no significant difference in any VTE or major bleeding between UFH and dalteparin. Patients with severe renal dysfunction who received dalteparin had more proxima…
View article: Fulminant liver failure in a street runner: Effects of heat stroke
Fulminant liver failure in a street runner: Effects of heat stroke Open
Summary We present a clinical case of liver failure induced by heat stroke.
View article: Impact of an inpatient multidisciplinary glucose control management program
Impact of an inpatient multidisciplinary glucose control management program Open
Objective: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate…
View article: Platelets: an outlook from biology through evidence-based achievements in critical care
Platelets: an outlook from biology through evidence-based achievements in critical care Open
Hospital Pro Cardíaco, Department of Critical Care. Rio de Janeiro RJ, Brazil / Trombocore, Haemostasis & Thrombosis Studies with roTEM® thromboelastometry directed to critically ill patients. Rio de Janeiro RJ, Brazil.
View article: Over 50 Years of Fibrinogen Concentrate
Over 50 Years of Fibrinogen Concentrate Open
March 2013 represented the 50th anniversary of the first license granted for a fibrinogen concentrate. In this review, we look at the history of bleeding management that led to the development of fibrinogen concentrate, discuss its current…