Rui Chen
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View article: Relationship between maternal social support and undernutrition among children under 5 years in Siem Reap Province, Cambodia: the chain mediating roles of household food insecurity and maternal depression
Relationship between maternal social support and undernutrition among children under 5 years in Siem Reap Province, Cambodia: the chain mediating roles of household food insecurity and maternal depression Open
Background Undernutrition among children under five years (CUFY) is a leading global public health issue worldwide, including in Cambodia. This study aimed to determine the prevalence of undernutrition and the mediating effect of maternal …
View article: Association between Anti-Helicobacter pylori IgG seropositivity on coronary heart disease and potential pathogenesis: a Mendelian randomization study
Association between Anti-Helicobacter pylori IgG seropositivity on coronary heart disease and potential pathogenesis: a Mendelian randomization study Open
Background Currently, observational studies and clinical trials have shown that the occurrence of coronary heart disease (CHD) is closely related to anti-Helicobacter pylori (H. pylori) IgG seropositivity, but these studies may be affected…
View article: Osteochondral Lesion of the Talus Amplifies Plantar Pressure Alterations and Postural Instability in Chronic Lateral Ankle Instability: A Cross‐Sectional Study Based on a Wearable Smart Plantar Pressure System
Osteochondral Lesion of the Talus Amplifies Plantar Pressure Alterations and Postural Instability in Chronic Lateral Ankle Instability: A Cross‐Sectional Study Based on a Wearable Smart Plantar Pressure System Open
Background Chronic lateral ankle instability (CLAI) is frequently complicated by osteochondral lesion of the talus (OLT), which accelerate cartilage degeneration due to abnormal stress concentration and may progress to ankle osteoarthritis…
View article: Role of non-coding RNAs in radiotherapy sensitivity in non-small cell lung cancer
Role of non-coding RNAs in radiotherapy sensitivity in non-small cell lung cancer Open
Lung cancer (LC) is consistently the leading cause of cancer-related deaths worldwide. Radiotherapy is a crucial means of treating LC, and about 60-70% of LC patients require radiotherapy. However, radiotherapy resistance remains a signifi…
View article: An open-label Phase II trial of VDJ-001, a high-affinity IL-6R antagonist antibody, for the treatment of patients with idiopathic multicentric castleman disease
An open-label Phase II trial of VDJ-001, a high-affinity IL-6R antagonist antibody, for the treatment of patients with idiopathic multicentric castleman disease Open
Interleukin-6 (IL-6) targeted therapy has been recommended as the most important treatment option for idiopathic Multicentric Castleman Disease (iMCD). Although siltuximab has been approved in many countries, this first IL-6 blocking antib…
View article: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Firsekibart, an Anti-interleukin-1β Monoclonal Antibody, in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Firsekibart, an Anti-interleukin-1β Monoclonal Antibody, in Healthy Chinese Participants: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study Open
ClinicalTrials.gov NCT04337437 (retrospectively registered on April 7, 2020).
View article: Exploring the Top 50 Drugs Associated with Restless Legs Syndrome Based on the FDA Data from 2004 to 2024
Exploring the Top 50 Drugs Associated with Restless Legs Syndrome Based on the FDA Data from 2004 to 2024 Open
Our study highlights drugs potentially linked to drug-associated RLS emphasizing the need to consider these risks in clinical practice.
View article: The protective role of 3-Indoleglyoxylic acid in Bisphenol S-induced intestinal barrier dysfunction via mitochondrial ROS-Mediated IL-17/CXCL10/TNF-α signaling
The protective role of 3-Indoleglyoxylic acid in Bisphenol S-induced intestinal barrier dysfunction via mitochondrial ROS-Mediated IL-17/CXCL10/TNF-α signaling Open
Bisphenol S (BPS) has become extensively used in the manufacturing of consumer products. BPS mainly enters the body through food and water, with oral exposure targeting the gastrointestinal tract. However, its safety profile remains conten…
View article: Prevalence, Risk Factors of Preserved Ratio Impaired Spirometry in adult in plateau: A Cross-Sectional Study
Prevalence, Risk Factors of Preserved Ratio Impaired Spirometry in adult in plateau: A Cross-Sectional Study Open
Background Preserved ratio impaired spirometry(PRISm) is considered to be a precursor of COPD. The purpose of our study is to investigate the prevalence and risk factors of PRISm in high-altitude areas. Methods The adult residents of Hongy…
View article: WITHDRAWN: An ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of deoxycholic acid and application to a pharmacokinetic study in human plasma
WITHDRAWN: An ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of deoxycholic acid and application to a pharmacokinetic study in human plasma Open
This article has been withdrawn at the request of the author(s) and/or editor due to an error in the publishing process. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be f…
View article: Influence of experimental variables on spheroid attributes
Influence of experimental variables on spheroid attributes Open
The adoption of three-dimensional (3D) cell culture systems represents a critical advancement in biomedical research, better mimicking complex 3D tissue environments than traditional two-dimensional (2D) models. However, variability in exp…
View article: The effcet of annulus fibrosus suture combined with percutaneous transforaminal endoscopic discectomy on obese patients with lumbar disc herniation
The effcet of annulus fibrosus suture combined with percutaneous transforaminal endoscopic discectomy on obese patients with lumbar disc herniation Open
Background Lumbar disc herniation (LDH) is a prevalent degenerative disc disorder frequently resulting in lumbar and leg pain. Obese patients with LDH often encounter the scenario where the disc herniation is not completely resolved in the…
View article: Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria
Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria Open
Chronic urticaria (CU) arises from a multifaceted interplay of immunological, neurological, and psychological components. Immune dysregulation, mediated through both immunoglobulin E (IgE)-dependent and IgE-independent pathways, plays a pi…
View article: The CYP2D6 phenotyping performance of single-point saliva metabolic ratio in a healthy Chinese Han population
The CYP2D6 phenotyping performance of single-point saliva metabolic ratio in a healthy Chinese Han population Open
The CYP2D6 plays critical roles in drug metabolism, and its inter-individual variability should be properly addressed in clinical practice. Our research aimed to assess the performance of single-point saliva metabolic ratio (MR) in a healt…
View article: miR-21 regulates LPS-induced apoptosis and inflammatory injury in rat cardiomyocytes by targeting PLD1 and STAT3
miR-21 regulates LPS-induced apoptosis and inflammatory injury in rat cardiomyocytes by targeting PLD1 and STAT3 Open
This study aims to elucidate the role and molecular mechanism of microRNA-21 (miR-21) in LPS-induced inflammatory injury in H9c2 cardiomyocytes. H9c2 cardiomyocytes were treated with lipopolysaccharide (LPS) to establish an in vitro model.…
View article: X-ray spectrum estimation from the transmission method using the radioluminescence of an Al2O3:C crystal
X-ray spectrum estimation from the transmission method using the radioluminescence of an Al2O3:C crystal Open
The X-ray spectrum of X-ray tube is crucial for radiation dose calculations. Due to the high photon flux, it is difficult to directly measure the primary spectrum of X-ray tube. Transmission measurement is one of indirect method used to de…
View article: Emotional nursing by syndrome differentiation combined with narrative nursing for a patient with blood stasis and qi stagnation type lumbar disc herniation accompanied by emotional distress
Emotional nursing by syndrome differentiation combined with narrative nursing for a patient with blood stasis and qi stagnation type lumbar disc herniation accompanied by emotional distress Open
This paper summarized the practice of emotional nursing by syndrome differentiation combined with narrative nursing for a patient with blood stasis and qi stagnation type lumbar disc herniation accompanied by emotional distress. Based on t…
View article: The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway
The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway Open
The serine protease CORIN catalyzes pro‐atrial natriuretic peptide (pro‐ANP) into an active ANP and maintains homeostasis of the internal environment. However, it is unclear whether CORIN participates in the regulation of tumor progression…
View article: Dynamic Changes in Neuron-specific Enolase Level to Glasgow Coma Scale Score Ratio Predict Long-term Neurological Function of Diffuse Axonal Injury Patients
Dynamic Changes in Neuron-specific Enolase Level to Glasgow Coma Scale Score Ratio Predict Long-term Neurological Function of Diffuse Axonal Injury Patients Open
Background Patients with diffuse axonal injury (DAI) are often plagued by sequelae, and the current indicators for predicting long-term neurological function are not accurate enough. Our previous studies have found that serum Neuron-specif…
View article: Effect of Intraoperative Opioid Dose on Perioperative Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Glioma
Effect of Intraoperative Opioid Dose on Perioperative Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Glioma Open
Intraoperative opioids in the high-dose group were associated with higher NLR and lower LMR in postoperative glioma patients. The preoperative NLR and LMR demonstrated predictive value for distinguishing between high-grade and low-grade gl…
View article: The serum metabolome of diffuse axonal injury patients is distinctive and predictive
The serum metabolome of diffuse axonal injury patients is distinctive and predictive Open
Background Metabolism is essential for life maintenance, neurological function and injury repair, yet its role in diffuse axonal injury (DAI) is not fully understood. Methods 30 DAI patients and 34 non-DAI patients were recruited based on …
View article: The Effects of Different Exercise Interventions on Patients with Subjective Cognitive Decline: A Systematic Review and Network Meta-Analysis
The Effects of Different Exercise Interventions on Patients with Subjective Cognitive Decline: A Systematic Review and Network Meta-Analysis Open
Mind-body exercise may potentially be the optimal strategies for enhancing memory and executive function in individuals with subjective cognitive decline. Additionally, moderate-intensity aerobic exercise has shown a modest positive effect…