Ruby C.Y. Lin
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View article: Phage therapy: An international survey of attitudes and experiences amongst clinicians
Phage therapy: An international survey of attitudes and experiences amongst clinicians Open
These results serve as a guiding initiative to improve phage therapy integration in healthcare.
View article: Attitudes to phage therapy among Australian infectious diseases physicians
Attitudes to phage therapy among Australian infectious diseases physicians Open
These results suggest the support of phage therapy among infectious diseases and clinical microbiology advanced trainees and specialists in Australia, and highlights areas of focus and priority in order to advance phage therapy.
View article: Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation
Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation Open
PI3K(p110α) is a critical regulator of atrial biology and function in mice. This work provides a proteomic resource of candidates for further validation as potential new drug targets and biomarkers for atrial myopathy. Further investigatio…
View article: Policy in practice: Cystic Fibrosis Australia and Phage Australia surveys: understanding clinical needs and attitudes towards phage therapy in the cystic fibrosis community
Policy in practice: Cystic Fibrosis Australia and Phage Australia surveys: understanding clinical needs and attitudes towards phage therapy in the cystic fibrosis community Open
Cystic fibrosis (CF) is the most prevalent serious inherited disease in Australia, imposing significant health risks. CF is characterized by chronic lung inflammation and recurrent pulmonary infections that increase morbidity and premature…
View article: Cystic Fibrosis Australia and Phage Australia survey: Understanding clinical needs and attitudes towards phage therapy in the CF community
Cystic Fibrosis Australia and Phage Australia survey: Understanding clinical needs and attitudes towards phage therapy in the CF community Open
Cystic fibrosis (CF) is the most prevalent serious inherited disease in Australia, imposing significant health risks. CF is characterised by chronic lung inflammation and recurrent pulmonary infections that increase morbidity and premature…
View article: Phage Therapy in Korea: A Prescribers' Survey of Attitudes Amongst Korean Infectious Diseases Specialists Towards Phage Therapy
Phage Therapy in Korea: A Prescribers' Survey of Attitudes Amongst Korean Infectious Diseases Specialists Towards Phage Therapy Open
Korean infectious diseases specialists are receptive to phage therapy, but a better understanding of safety, efficacy and clinical trials are warranted to progress phage therapy within the Korean healthcare system.
View article: Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival
Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival Open
There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these bacteriophages may have on mammalian cellular and immunological…
View article: Attitudes to phage therapy among Australian infectious diseases physicians
Attitudes to phage therapy among Australian infectious diseases physicians Open
Due to the rise in antimicrobial resistance (AMR), there has been an increased interest in phage therapy to treat multi-drug resistant infections. In Australia, phage therapy is predominantly used in small clinical studies or for compassio…
View article: Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival
Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival Open
There is a growing appreciation that the direct interaction between bacteriophages and the mammalian host can facilitate diverse and unexplored symbioses. Yet the impact these bacteriophages may have on mammalian cellular and immunological…
View article: Standardised treatment and monitoring protocol to assess safety and tolerability of bacteriophage therapy for adult and paediatric patients (STAMP study): protocol for an open-label, single-arm trial
Standardised treatment and monitoring protocol to assess safety and tolerability of bacteriophage therapy for adult and paediatric patients (STAMP study): protocol for an open-label, single-arm trial Open
Introduction There has been renewed interest in the therapeutic use of bacteriophages (phages); however, standardised therapeutic protocols are lacking, and there is a paucity of rigorous clinical trial data assessing efficacy. Methods and…
View article: Novel gene–intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy
Novel gene–intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy Open
Distal hereditary motor neuropathies (dHMNs) are a group of inherited diseases involving the progressive, length-dependent axonal degeneration of the lower motor neurons. There are currently 29 reported causative genes and four disease loc…
View article: 3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies
3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies Open
Traditional studies using cancer cell lines are often performed on a two-dimensional (2D) cell culture model with a low success rate of translating to Phase I or Phase II clinical studies. In comparison, with the advent of developments thr…
View article: Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy: A new mechanism for motor neuron degeneration
Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy: A new mechanism for motor neuron degeneration Open
Distal hereditary motor neuropathies (dHMNs) are a group of inherited diseases involving the progressive, length-dependent axonal degeneration of the lower motor neurons. There are currently 29 reported causative genes and 4 disease loci i…
View article: Data to Power Precision Phage Therapy: A Look at the Phage Directory–Phage Australia Partnership
Data to Power Precision Phage Therapy: A Look at the Phage Directory–Phage Australia Partnership Open
Phage Directory has recently partnered with Phage Australia to help optimize Australia's data-centric standardized approach to personalized phage therapy. Here is a behind-the-scenes look at the genesis of Phage Australia, how the Phage Di…
View article: Accuracy of Magnetic Resonance Imaging for Identifying Ovarian Cancer in a Community-Based Setting
Accuracy of Magnetic Resonance Imaging for Identifying Ovarian Cancer in a Community-Based Setting Open
Introduction: Many ovarian or adnexal masses have an indeterminate appearance on ultrasound that can raise concerns about cancer. Although magnetic resonance imaging (MRI) has been reported to reliably distinguish between benign and malign…
View article: Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child
Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child Open
Adjunctive phage therapy was used in an attempt to avoid catastrophic outcomes from extensive chronic Pseudomonas aeruginosa osteoarticular infection in a 7-year-old child. Monitoring of phage and bacterial kinetics allowed real-time phage…
View article: Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure
Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure Open
The mechanisms underpinning beta‐cell compensation for obesity‐associated insulin resistance and beta‐cell failure in type 2 diabetes remain poorly understood. We used a large‐scale strategy to determine the time‐dependent transcriptomic c…
View article: A Phage Therapy Guide for Clinicians and Basic Scientists: Background and Highlighting Applications for Developing Countries
A Phage Therapy Guide for Clinicians and Basic Scientists: Background and Highlighting Applications for Developing Countries Open
Approximately 10% of global health research is devoted to 90% of global disease burden (the so-called “10/90 Gap”) and it often neglects those diseases most prevalent in low-income countries. Antibiotic resistant bacterial infections are k…
View article: Rapid automated system for bacteriophage virulence and antibiotic synergy testing – The ‘phago-antibiogram’
Rapid automated system for bacteriophage virulence and antibiotic synergy testing – The ‘phago-antibiogram’ Open
Background: The global emergence of multidrug resistant bacteria in the context of desiccating antimicrobial drug pipeline has led to resurgent interest in bacteriophage therapy (BT) to treat serious bacterial infections. Phages are highly…
View article: Therapeutic monitoring of the host-bacterium-phage interaction in a child
Therapeutic monitoring of the host-bacterium-phage interaction in a child Open
Successful phage therapy for extensive chronic osteoarticular infection in a child resulted in an initial flush of bacterial contents into the bloodstream with an inflammatory response marked by fever, local pain and upregulation of genes …
View article: Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice
Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice Open
Skeletal glucocorticoid signalling is critical for the development of leptin resistance, obesity and insulin resistance during aging. These findings underscore the skeleton's importance in the regulation of body weight and implicate osteob…
View article: Vascular transcriptome landscape of <i>Trail</i> <sup>−/−</sup> mice: Implications and therapeutic strategies for diabetic vascular disease
Vascular transcriptome landscape of <i>Trail</i> <sup>−/−</sup> mice: Implications and therapeutic strategies for diabetic vascular disease Open
Circulating plasma TRAIL levels are suppressed in patients with cardiovascular and diabetic diseases. To identify novel targets in vascular metabolic diseases, genome‐wide transcriptome of aortic tissue from Trail −/− versus Trail +/+ mice…
View article: Characterizing the role of porin mutations in susceptibility of beta lactamase producing Klebsiella pneumoniae isolates to ceftaroline and ceftaroline-avibactam
Characterizing the role of porin mutations in susceptibility of beta lactamase producing Klebsiella pneumoniae isolates to ceftaroline and ceftaroline-avibactam Open
Outer membrane porins play a key role in the transport of ceftaroline inKlebsiella pneumoniae but it remains effective in isolates with altered permeability due to common porin mutations. The addition of avibactam substantially enhances th…
View article: Phage therapy for severe bacterial infections: a narrative review
Phage therapy for severe bacterial infections: a narrative review Open
Bacteriophage (phage) therapy is re-emerging a century after it began. Activity against antibiotic-resistant pathogens and a lack of serious side effects make phage therapy an attractive treatment option in refractory bacterial infections.…
View article: Safety and Tolerability of Bacteriophage Therapy in Severe <i>Staphylococcus aureus</i> Infection
Safety and Tolerability of Bacteriophage Therapy in Severe <i>Staphylococcus aureus</i> Infection Open
Importance The effect of IV administration of a bacteriophage cocktail produced under GMP conditions on patients with severe S. aureus infection, including complicated bacteraemia, endocarditis and septic shock, is unknown. Objective To as…
View article: Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases
Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases Open
Adrenocortical carcinoma is a rare malignancy with a poor prognosis and few treatment options. Molecular characterization of this cancer remains limited. We present a case of an adrenocortical carcinoma (ACC) in a 37-yr-old female, with du…
View article: Volume 40 Number 1
Volume 40 Number 1 Open
In order to avoid a return to the pre-antibiotic era, alternative treatments to combat microbial diseases are urgently needed.In this context, bacteriophages, which have been used effectively in distant parts of the world during the cold w…
View article: Bacteriophage therapy for severe infections
Bacteriophage therapy for severe infections Open
The rise of multiple antibiotic resistance in clinically relevant bacteria has created a global crisis with increasing burden on healthcare systems. The need to optimise alternative therapies to antibiotics, particularly in high risk nosoc…