Ruixia Guo
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View article: Identification and susceptibility assessment of landslides along railway lines using MPSO-RF considering INSAR deformation
Identification and susceptibility assessment of landslides along railway lines using MPSO-RF considering INSAR deformation Open
With the continuous promotion of railway construction in China, railway lines are increasingly extended to areas with complex geological environment, and such areas are prone to landslides and other geological disasters, which seriously th…
View article: Near infrared II excitation conjugated polymers-based phototheranostic nanoplatform for hyperthermia-enhanced ferroptosis and immunotherapy
Near infrared II excitation conjugated polymers-based phototheranostic nanoplatform for hyperthermia-enhanced ferroptosis and immunotherapy Open
Ferroptosis has the potential to induce immunogenic cell death (ICD) and remodel the immunosuppressive tumor microenvironment (TME). However, intracellular antioxidant glutathione (GSH) inhibits the efficacy of ferroptosis. Consequently, e…
View article: Management and prognosis of ultra high-risk gestational trophoblastic neoplasia patients: a long-term retrospective study
Management and prognosis of ultra high-risk gestational trophoblastic neoplasia patients: a long-term retrospective study Open
Background: The prognosis for patients with ultra high-risk gestational trophoblastic neoplasia (GTN) is significantly worse, and there is currently no consensus regarding the optimal treatment strategies for this specific patient populati…
View article: Attenuated crosstalk between urothelium and fibroblasts promotes ureteral stricture development Urothelial-Fibroblast Crosstalk in Stricture
Attenuated crosstalk between urothelium and fibroblasts promotes ureteral stricture development Urothelial-Fibroblast Crosstalk in Stricture Open
Background Ureteral stricture (US), characterized by fibrotic remodeling of the ureteral wall, represents an obstructive urological disorder with incompletely characterized pathophysiological mechanisms. This study integrates single-cell R…
View article: Veillonella Associates with Platinum Resistance in Ovarian Cancer: Insights from Gut Microbiota Profiling and In Vitro Functional Validation
Veillonella Associates with Platinum Resistance in Ovarian Cancer: Insights from Gut Microbiota Profiling and In Vitro Functional Validation Open
Background Ovarian cancer (OC) remains the most lethal gynecologic malignancy, primarily due to high recurrence rates and frequent development of platinum resistance. While the gut microbiome is known to influence tumor progression and the…
View article: Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies Open
Abnormal glucose metabolism inevitably disrupts normal neuronal function, a phenomenon widely observed in Alzheimer’s disease (AD). Investigating the mechanisms of metabolic adaptation during disease progression has become a central focus …
View article: [Megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and early-stage endometrial adenocarcinoma: a prospective study].
[Megestrol acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and early-stage endometrial adenocarcinoma: a prospective study]. Open
Metformin combined with MA may provide an effective option for fertility-sparing treatment of AEH and grade 1 stage IA EAC, and the clinical benefits of metformin for controlling MA-induced weight gain and promoting endometrial expressions…
View article: Efficacy of PD-1/PD-L1 blockade immunotherapy in recurrent/metastatic high-grade neuroendocrine carcinoma of the cervix: A retrospective study
Efficacy of PD-1/PD-L1 blockade immunotherapy in recurrent/metastatic high-grade neuroendocrine carcinoma of the cervix: A retrospective study Open
Although high-grade neuroendocrine carcinoma of the cervix (HGNECC) accounts for less than 1 % of all cervical cancers, it exhibits marked aggressiveness and resistance to radiation and chemotherapy. We retrospectively investigated the eff…
View article: Hypermethylated RASAL1’s promotive role in chemoresistance and tumorigenesis of choriocarcinoma was regulated by TET2 but not DNMTs
Hypermethylated RASAL1’s promotive role in chemoresistance and tumorigenesis of choriocarcinoma was regulated by TET2 but not DNMTs Open
Taken together, the present data elucidated that reduced RASAL1 through its promoter hypermethylation regulated by TET2 promoted the tumorigenicity and chemoresistance of CC via modulating β-catenin both in vitro and in vivo.
View article: Crystal structure of 1-cyclohexyl-4-<i>p</i>-tolyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester, C<sub>22</sub>H<sub>27</sub>NO<sub>4</sub>
Crystal structure of 1-cyclohexyl-4-<i>p</i>-tolyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester, C<sub>22</sub>H<sub>27</sub>NO<sub>4</sub> Open
C 22 H 27 NO 4 , triclinic, P 1 ‾ $P\overline{1}$ (no. 2), a = 9.3356(8) Å, b = 10.2842(11) Å, c = 11.5902(12) Å, α = 103.266(4)°, β = 106.189(3)°, γ = 97.779(4)°, V = 1016.20(18) Å 3 , Z = 2, R gt ( F ) = 0.0413, w R ref ( F 2 ) = 0…
View article: Comprehensive analysis of single cell and bulk data develops a promising prognostic signature for improving immunotherapy responses in ovarian cancer
Comprehensive analysis of single cell and bulk data develops a promising prognostic signature for improving immunotherapy responses in ovarian cancer Open
The tumor heterogeneity is an important cause of clinical therapy failure and yields distinct prognosis in ovarian cancer (OV). Using the advantages of integrated single cell RNA sequencing (scRNA-seq) and bulk data to decode tumor heterog…
View article: Is robotic-assisted vaginectomy a better choice in vaginal high-grade squamous intraepithelial lesions than conventional laparoscopic surgery?
Is robotic-assisted vaginectomy a better choice in vaginal high-grade squamous intraepithelial lesions than conventional laparoscopic surgery? Open
Background Vaginectomy has been shown to be effective for select patients with vaginal high-grade squamous intraepithelial lesions (HSIL) and is favored by gynecologists, while there are few reports on the robotic-assisted laparoscopic vag…
View article: Genetic landscape of homologous recombination repair and practical outcomes of PARPi therapy in ovarian cancer management
Genetic landscape of homologous recombination repair and practical outcomes of PARPi therapy in ovarian cancer management Open
Background: Genetic studies of ovarian cancer (OC) have historically focused on BRCA1/2 mutations, lacking other studies of homologous recombination repair (HRR). Poly (ADP-ribose) polymerase inhibitors (PARPi) exploit synthetic lethality …
View article: Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation
Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation Open
Radioresistance is the major obstacle that affects the efficacy of radiotherapy which is an important treatment for cervical cancer. By analyzing the databases, we found that aldolase A (ALDOA), which is a key enzyme in metabolic reprogram…
View article: Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein
Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein Open
Background Radiotherapy is widely used in treating cervical cancer patients, however, radioresistance unavoidably occurs and seriously affects the treatment effect. It is well known that hypoxia plays an important role in promoting radiore…
View article: EP130/#706 IGFBP2 regulates glucose metabolism reprogramming through PKM2 to promote endometrial adenocarcinoma progression
EP130/#706 IGFBP2 regulates glucose metabolism reprogramming through PKM2 to promote endometrial adenocarcinoma progression Open
Introduction Endometrial cancer (EC) is one of the most common malignant tumors in the female reproductive system. The incidence and mortality of EC have been increasing in the past 40 years.As an important member of the insulin-like growt…
View article: EP415/#186 Is robotic-assisted surgery a better choice in vaginectomy of complicated vaginal high-grade squamous intraepithelial lesions than conventional laparoscopic surgery?
EP415/#186 Is robotic-assisted surgery a better choice in vaginectomy of complicated vaginal high-grade squamous intraepithelial lesions than conventional laparoscopic surgery? Open
Introduction The aim of this study was to evaluate the operative outcomes of robotic-assisted laparoscopic vaginectomy (RALV) and conventional laparoscopic vaginectomy (CLV) for patients with complicated vaginal high-grade squamous intraep…
View article: Long noncoding RNA MCM3AP-AS1 promotes ovarian cancer cells progression by modulating miR-383/DDIT4 axis
Long noncoding RNA MCM3AP-AS1 promotes ovarian cancer cells progression by modulating miR-383/DDIT4 axis Open
Long non-coding RNA (lncRNA) was recently reported to be implicated in cancer progression. However, the role of MCM3AP-AS1 in ovarian cancer (OC) remains undetected. In this study, MCM3AP-AS1 expression was elevated in OC tissues. High MCM…
View article: Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia
Low m6A modification-mediated upregulation of PLAC8 promotes trophoblast cell invasion and migration in preeclampsia Open
Background The main symptoms of preeclampsia (PE), a specific ailment that develops during pregnancy, are proteinuria and hypertension. The pathological root of the onset and progression of PE is widely regarded as abnormal placental troph…
View article: Comprehensive Analysis of the Expression of IGFBPs and its Correlation with Prognosis and Immune in Endometrial Cancer
Comprehensive Analysis of the Expression of IGFBPs and its Correlation with Prognosis and Immune in Endometrial Cancer Open
Endometrial cancer (EC) is one of the most common malignant tumors of the female reproductive tract. Insulin-like growth factor-binding proteins (IGFBPs) as regulators of IGF signaling in cancer are of increasing interest. However, the rol…
View article: Effectiveness and safety of prophylactic abdominal aortic balloon occlusion for patients with type III caesarean scar pregnancy: a prospective cohort study
Effectiveness and safety of prophylactic abdominal aortic balloon occlusion for patients with type III caesarean scar pregnancy: a prospective cohort study Open
Background Caesarean scar pregnancy (CSP) is a special type of ectopic pregnancy with a high risk of massive haemorrhage. Few studies have focused on the efficacy of prophylactic abdominal aortic balloon occlusion as a minimally invasive m…
View article: Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels
Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels Open
Intrauterine adhesion (IUA), also referred to as Asherman Syndrome (AS), results from uterine trauma in both pregnant and nonpregnant women. The IUA damages the endometrial bottom layer, causing partial or complete occlusion of the uterine…
View article: Prevalence and prognostic role of PD-L1 in patients with gynecological cancers: A systematic review and meta-analysis
Prevalence and prognostic role of PD-L1 in patients with gynecological cancers: A systematic review and meta-analysis Open
The prevalence of PD-L1-positive expression was considerably high in CC and modestly high in EC and OC patients. PD-L1 expression has the potential to be a prognostic biomarker for predicting the clinical outcomes of patients with CC and E…
View article: Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review)
Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review) Open
Endometrial cancer (EC) ranks as the sixth most common malignancy in women around the world. Although low‑grade and early‑stage EC commonly have an excellent prognosis, ~20% of EC patients experience an unfavorable prognosis. Identifying t…