Ruby Kochappan
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View article: mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting
mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting Open
To address the limitations of whole-spike COVID vaccines, we explored mRNA vaccines encoding membrane-anchored receptor-binding domain (RBD-TMs), each a fusion of a variant RBD, the transmembrane (TM) and cytoplasmic tail (CT) fragments of…
View article: Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice
Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice Open
The mesenteric lymph nodes (MLN) are a key site for the generation of adaptive immune responses to gut-derived antigenic material and immune cells within the MLN contribute to the pathophysiology of a range of conditions including inflamma…
View article: The pharmacodynamic benefits of oral triglyceride mimetic prodrugs to lymphatic system
The pharmacodynamic benefits of oral triglyceride mimetic prodrugs to lymphatic system Open
The lymphatic system plays important roles in maintaining fluid balance, the transport of dietary fat and immune surveillance. The intestinal lymphatic system harbors a large population of immune cells an is therefore a target for immune m…