Ruby Persaud
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View article: Exposure Risks from Microbiological Hazards in Buildings and Their Control—A Rapid Review of the Evidence
Exposure Risks from Microbiological Hazards in Buildings and Their Control—A Rapid Review of the Evidence Open
A rapid review was undertaken to consider the evidence for human exposure to harmful microorganisms from indoor air and surfaces. Published information about these contaminants, as well as measures to control them, including building desig…
View article: Vaccine-induced antibodies are sufficient to limit <i>Salmonella</i> infection in the absence of complement or macrophages
Vaccine-induced antibodies are sufficient to limit <i>Salmonella</i> infection in the absence of complement or macrophages Open
Summary Antibodies to Salmonella Typhimurium (STm) can protect against infection. Understanding better how antibodies, complement, and leukocytes interplay can support vaccine development. We used an Outer Membrane Vesicle (OMV) vaccine ag…
View article: Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection
Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection Open
Inflammation-induced thrombosis is a common consequence of bacterial infections, such as those caused by Salmonella Typhimurium (STm). The presentation of multi-organ thrombosis post-infection that develops and resolves with organ-specific…
View article: Wild-type and single-O-antigen repeat outer-membrane vesicles induce equivalent protection against homologous and heterologous<i>Salmonella</i>challenge
Wild-type and single-O-antigen repeat outer-membrane vesicles induce equivalent protection against homologous and heterologous<i>Salmonella</i>challenge Open
Lipopolysaccharide O-antigen is an immunodominant target of protective antibodies. Variation in O-antigen structures limits antibody-mediated cross-protection between closely-related pathogens including Salmonella Typhimurium (STm) and S .…
View article: Discrete and conserved inflammatory signatures drive thrombosis in different organs after<i>Salmonella</i>infection
Discrete and conserved inflammatory signatures drive thrombosis in different organs after<i>Salmonella</i>infection Open
Inflammation-induced thrombosis is a common consequence of bacterial and viral infections, such as those caused by Salmonella Typhimurium (STm) and SARS-CoV-2. The identification of multi-organ thrombosis and the chronological differences …
View article: Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses Open
Introduction Vaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better …
View article: Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers
Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers Open
Germinal centers (GCs) are sites where plasma and memory B cells form to generate high-affinity, Ig class-switched antibodies. Specialized stromal cells called follicular dendritic cells (FDCs) are essential for GC formation. During system…
View article: Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses Open
Vaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better protection in…
View article: <i>Salmonella</i>infection induces the reorganisation of follicular dendritic cell networks concomitant with the failure to generate germinal centres
<i>Salmonella</i>infection induces the reorganisation of follicular dendritic cell networks concomitant with the failure to generate germinal centres Open
Summary Germinal centres (GCs) are sites where plasma and memory B cells form to generate high-affinity, Ig class switched antibodies. Specialised stromal cells called follicular dendritic cells (FDCs) are essential for GC formation. Durin…
View article: Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile
Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile Open
Mucosal vaccination aims to prevent infection mainly by inducing secretory IgA (sIgA) antibody, which neutralises pathogens and enterotoxins by blocking their attachment to epithelial cells. We previously demonstrated that encapsulated pro…
View article: Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains
Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains Open
Despite high vaccination coverage, Bordetella pertussis the causative agent of whooping cough is still a health concern worldwide. A resurgence of pertussis cases has been reported, particularly in countries using acellular vaccines with w…
View article: Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain <i>Salmonella</i>
Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain <i>Salmonella</i> Open
Clearance of intracellular infections caused by Salmonella Typhimurium (STm) requires IFN-γ and the Th1-associated transcription factor T-bet. Nevertheless, whereas IFN-γ−/− mice succumb rapidly to STm infections, T-bet−/− mice do not. In …
View article: <i>Bordetella pertussis</i> isolates vary in their interactions with human complement components
<i>Bordetella pertussis</i> isolates vary in their interactions with human complement components Open
Whooping cough is a re-emerging respiratory tract infection. It has become clear that there is a need for better understanding of protective immune responses and variation between Bordetella pertussis strains to aid the development of impr…