Ruby Ray
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View article: Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a multicentre, interventional open-label, randomised controlled trial
Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a multicentre, interventional open-label, randomised controlled trial Open
Introduction Despite repeated vaccinations against SARS-CoV-2 virus, patients who are immunocompromised remain at very high risk of catching SARS-CoV-2 virus and becoming unwell. AZD7442 (Evusheld) is a long-acting monoclonal antibody trea…
View article: Gut microbiology of UK care home residents: a cross-sectional analysis from a randomised controlled trial
Gut microbiology of UK care home residents: a cross-sectional analysis from a randomised controlled trial Open
We demonstrated that care home residents harbour significant levels of antimicrobial-resistant organisms in their stool. This work emphasises the importance of both enhanced infection control practices and antimicrobial stewardship program…
View article: 2022-RA-941-ESGO CEBOC, a single-arm phase II trial to evaluate the safety of cediranib in the prevention of bowel perforation in platinum resistant ovarian cancer
2022-RA-941-ESGO CEBOC, a single-arm phase II trial to evaluate the safety of cediranib in the prevention of bowel perforation in platinum resistant ovarian cancer Open
Introduction/Background Systemic treatment of platinum-resistant advanced ovarian cancers (PROC) utilises cytotoxic chemotherapy and vascular endothelial growth factor receptor (VEGFR) inhibitors. However, patients at risk for malignant bo…
Use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the <span>UK</span> : a national, multispeciality survey of clinicians Open
Skin cancer is the most common malignancy in the UK, and up to a third of lesions are ulcerated at the time of excision. Ulceration has been shown to increase the risk of developing surgical site infection following excision, with some stu…
A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS Open
The regimen was well tolerated with effective downstaging and encouraging PFS. mrTRG response to NAC may be a new prognostic factor for long-term PFS, but needs validation in larger studies.
NEOSCOPE: A randomised phase II study of induction chemotherapy followed by oxaliplatin/capecitabine or carboplatin/paclitaxel based pre-operative chemoradiation for resectable oesophageal adenocarcinoma Open
Both regimens were well tolerated. Only CarPacRT passed the predefined pCR criteria for further investigation.
Prospective review of radiotherapy trials through implementation of standardized multicentre workflow and IT infrastructure Open
Trial groups around the world have formulated different approaches to address the need for the prospective review of radiotherapy (RT) data with clinical trials, in line with available resources. We report a UK solution that has allowed th…