Ruby Redlich
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View article: RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution
RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution Open
Comparative genomics approaches seek to associate molecular evolution with the evolution of phenotypes across a phylogeny. Many of these methods lack the ability to analyze non-ordinal categorical traits with more than two categories. To a…
View article: Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements Open
Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from t…
View article: RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution
RERconverge Expansion: Using Relative Evolutionary Rates to Study Complex Categorical Trait Evolution Open
Comparative genomics approaches seek to associate evolutionary genetic changes with the evolution of phenotypes across a phylogeny. Many of these methods, including our evolutionary rates based method, RERconverge, lack the capability of a…
View article: Evolutionary constraint and innovation across hundreds of placental mammals
Evolutionary constraint and innovation across hundreds of placental mammals Open
Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least 332 million bases …
View article: Evolutionary constraint and innovation across hundreds of placental mammals
Evolutionary constraint and innovation across hundreds of placental mammals Open
Evolutionary constraint and acceleration are powerful, cell-type agnostic measures of functional importance. Previous studies in mammals were limited by species number and reliance on human-referenced alignments. We explore the evolution o…