Ruby S. M. Tsang
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View article: Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort
Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort Open
Depression is associated with immunological and metabolic alterations, but immunometabolic characteristics of developmental trajectories of depressive symptoms remain unclear. Studies of longitudinal trends of depressive symptoms in young …
View article: Correcting for the Inflated Adult Population Denominator in an English Nationwide Health Care Cohort: Database Analysis Study
Correcting for the Inflated Adult Population Denominator in an English Nationwide Health Care Cohort: Database Analysis Study Open
Background Electronic health care databases are widely used for epidemiological studies. However, they may contain inactive records of individuals no longer participating in the health care system. These inactive records create a methodolo…
View article: Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBank
Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK BioBank Open
Background Internalising and CardioMetabolic MultiMorbidity (ICM-MM) is a common form of mental-physical health multimorbidity, yet its genetic predisposition is largely unknown. We examined the polygenic nature of ICM-MM by assessing sing…
View article: The impact of genetic and sociodemographic factors on life course trajectories of physical-mental health multimorbidity in a UK South Asian cohort
The impact of genetic and sociodemographic factors on life course trajectories of physical-mental health multimorbidity in a UK South Asian cohort Open
Background UK South Asian populations have a high risk of many cardiometabolic and internalising mental health conditions such as depression and anxiety, and they commonly co-exist as physical and mental health multimorbidity. However, the…
View article: Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK Biobank
Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK Biobank Open
Background Internalising and cardiometabolic multimorbidity (ICM-MM) represents a major clinical challenge, negatively impacting life expectancy and quality of life and resulting in considerable healthcare costs. Individuals with a copy nu…
View article: Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults
Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults Open
Alterations in immuno-metabolic homeostasis is present in young adults with depression well before the typical age of onset of cardiometabolic diseases. The relationships between affective symptoms and blood immuno-metabolic biomarkers ind…
View article: Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in the UK Biobank
Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in the UK Biobank Open
Background Mood and anxiety disorders co-occur and share symptoms, treatments and genetic risk, but it is unclear whether combining them into a single phenotype would better capture genetic variation. The contribution of common genetic var…
View article: IMMUNOMETABOLIC PROFILING OF DEVELOPMENTAL TRAJECTORY SUBGROUPS OF DEPRESSIVE SYMPTOMS IN ALSPAC
IMMUNOMETABOLIC PROFILING OF DEVELOPMENTAL TRAJECTORY SUBGROUPS OF DEPRESSIVE SYMPTOMS IN ALSPAC Open
Background Depressive symptoms in childhood and adolescence are associated with an elevated risk of depression and other psychiatric diagnoses in adulthood. Therefore, delineating developmental trajectories of depressive symptoms can infor…
View article: Inflammation proteomic profiling of psychosis in young adults: Findings from the ALSPAC birth cohort
Inflammation proteomic profiling of psychosis in young adults: Findings from the ALSPAC birth cohort Open
Psychotic disorder is associated with altered levels of various inflammatory markers in blood, but existing studies have typically focused on a few selected biomarkers, have not examined specific symptom domains notably negative symptoms, …
View article: Immunometabolic Blood Biomarkers of Developmental Trajectories of Depressive Symptoms: Findings from the ALSPAC Birth Cohort
Immunometabolic Blood Biomarkers of Developmental Trajectories of Depressive Symptoms: Findings from the ALSPAC Birth Cohort Open
Depression is associated with immunological and metabolic alterations, but immunometabolic characteristics of developmental trajectories of depressive symptoms remain unclear. Studies of longitudinal trends of depressive symptoms in young …
View article: Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults
Blood Immuno-metabolic Biomarker Signatures of Depression and Affective Symptoms in Young Adults Open
Background Depression is associated with alterations in immuno-metabolic biomarkers, but it remains unclear whether these alterations are limited to specific markers, and whether there are subtypes of depression and depressive symptoms whi…
View article: Inflammation Proteomic Profiling of Psychosis in Young Adults: findings from the ALSPAC birth cohort
Inflammation Proteomic Profiling of Psychosis in Young Adults: findings from the ALSPAC birth cohort Open
Psychotic disorder is associated with altered levels of various inflammatory markers in blood, but existing studies have typically focused on a few selected biomarkers, have not examined specific symptom domains notably negative symptoms, …
View article: RETRACTED: Adverse events after first and second doses of COVID-19 vaccination in England: a national vaccine surveillance platform self-controlled case series study
RETRACTED: Adverse events after first and second doses of COVID-19 vaccination in England: a national vaccine surveillance platform self-controlled case series study Open
COVID-19 vaccines are associated with a small decrease in the incidence of medically attended AEIs. Sentinel networks could routinely report common AEI rates, which could contribute to reporting vaccine safety.
View article: COVID-19 vaccine effectiveness against hospitalisation and death of people in clinical risk groups during the Delta variant period: English primary care network cohort study
COVID-19 vaccine effectiveness against hospitalisation and death of people in clinical risk groups during the Delta variant period: English primary care network cohort study Open
View article: Hepatitis B virus infection in general practice across England: An analysis of the Royal College of General Practitioners Research and Surveillance Centre real-world database
Hepatitis B virus infection in general practice across England: An analysis of the Royal College of General Practitioners Research and Surveillance Centre real-world database Open
View article: Development of a modified Cambridge Multimorbidity Score for use with SNOMED CT: an observational English primary care sentinel network study
Development of a modified Cambridge Multimorbidity Score for use with SNOMED CT: an observational English primary care sentinel network study Open
Background People with multiple health conditions are more likely to have poorer health outcomes and greater care and service needs; a reliable measure of multimorbidity would inform management strategies and resource allocation. Aim To de…
View article: Adverse events following first and second dose COVID-19 vaccination in England, October 2020 to September 2021: a national vaccine surveillance platform self-controlled case series study
Adverse events following first and second dose COVID-19 vaccination in England, October 2020 to September 2021: a national vaccine surveillance platform self-controlled case series study Open
Background Post-authorisation vaccine safety surveillance is well established for reporting common adverse events of interest (AEIs) following influenza vaccines, but not for COVID-19 vaccines. Aim To estimate the incidence of AEIs present…
View article: COVID-19 booster vaccination uptake and infection breakthrough amongst health care workers in Wales: A national prospective cohort study
COVID-19 booster vaccination uptake and infection breakthrough amongst health care workers in Wales: A national prospective cohort study Open
View article: Representativeness, Vaccination Uptake, and COVID-19 Clinical Outcomes 2020-2021 in the UK Oxford-Royal College of General Practitioners Research and Surveillance Network: Cohort Profile Summary
Representativeness, Vaccination Uptake, and COVID-19 Clinical Outcomes 2020-2021 in the UK Oxford-Royal College of General Practitioners Research and Surveillance Network: Cohort Profile Summary Open
Background The Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) is one of Europe’s oldest sentinel systems, working with the UK Health Security Agency (UKHSA) and its predecessor bodies for 55 yea…
View article: Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales
Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales Open
Background Several SARS-CoV-2 vaccines have been shown to provide protection against COVID-19 hospitalization and death. However, some evidence suggests that notable waning in effectiveness against these outcomes occurs within months of va…
View article: Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales
Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales Open
National Core Studies-Immunity, UK Research and Innovation (Medical Research Council), Health Data Research UK, the Scottish Government, and the University of Edinburgh.
View article: Risk of thrombocytopenic, haemorrhagic and thromboembolic disorders following COVID-19 vaccination and positive test: a self-controlled case series analysis in Wales
Risk of thrombocytopenic, haemorrhagic and thromboembolic disorders following COVID-19 vaccination and positive test: a self-controlled case series analysis in Wales Open
View article: Second-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland
Second-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland Open
View article: Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021
Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021 Open
Introduction In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe. Aim Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection. Methods Individuals with CO…
View article: Methodological Issues in Using a Common Data Model of COVID-19 Vaccine Uptake and Important Adverse Events of Interest: Feasibility Study of Data and Connectivity COVID-19 Vaccines Pharmacovigilance in the United Kingdom
Methodological Issues in Using a Common Data Model of COVID-19 Vaccine Uptake and Important Adverse Events of Interest: Feasibility Study of Data and Connectivity COVID-19 Vaccines Pharmacovigilance in the United Kingdom Open
Background The Data and Connectivity COVID-19 Vaccines Pharmacovigilance (DaC-VaP) UK-wide collaboration was created to monitor vaccine uptake and effectiveness and provide pharmacovigilance using routine clinical and administrative data. …
View article: Representativeness, vaccination uptake and COVID clinical outcomes 2020-21 in the UK’s Oxford-RCGP Research and Surveillance Network: cohort profile. (Preprint)
Representativeness, vaccination uptake and COVID clinical outcomes 2020-21 in the UK’s Oxford-RCGP Research and Surveillance Network: cohort profile. (Preprint) Open
BACKGROUND The Oxford-Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) is one of Europe’s oldest sentinel systems, working with the UK Health Security Agency (UKHSA) and its predecessor bodies for 55 ye…
View article: Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network
Sociodemographic disparities in COVID-19 seroprevalence across England in the Oxford RCGP primary care sentinel network Open
View article: Methodological issues for using a common data model (CDM) of COVID-19 vaccine uptake and important adverse events of interest (AEIs): the Data and Connectivity COVID-19 Vaccines Pharmacovigilance (DaC-VaP) United Kingdom feasibility study. (Preprint)
Methodological issues for using a common data model (CDM) of COVID-19 vaccine uptake and important adverse events of interest (AEIs): the Data and Connectivity COVID-19 Vaccines Pharmacovigilance (DaC-VaP) United Kingdom feasibility study. (Preprint) Open
BACKGROUND The Data and Connectivity COVID-19 Vaccines Pharmacovigilance (DaC-VaP) UK-wide collaboration was created to monitor vaccine uptake and effectiveness and provide pharmacovigilance using routine clinical and administrative data.…
View article: Development and validation of a modified Cambridge Multimorbidity Score for use with internationally recognized electronic health record clinical terms (SNOMED CT)
Development and validation of a modified Cambridge Multimorbidity Score for use with internationally recognized electronic health record clinical terms (SNOMED CT) Open
Background People with multiple health conditions are more likely to have poorer health outcomes and greater care and service needs; a reliable measure of multimorbidity would inform management strategies and resource allocation. This stud…
View article: First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales
First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales Open
Background Several countries restricted the administration of ChAdOx1 to older age groups in 2021 over safety concerns following case reports and observed versus expected analyses suggesting a possible association with cerebral venous sinu…